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Omic-20 capsules is a medicine used to treat some diseases of gastroesophageal reflux, duodenal ulcer and benign stomach. To better understand what Omic-20 capsules are? Please read the article below.
1. What is Omic-20 capsules?
Omic-20 capsules is a medicine that works to treat diseases of the gastrointestinal tract with the main ingredient being Esomeprazole with a content of 20mg and some other excipients added to just 1 tablet.
Dosage form : Hard capsule
Pharmacodynamics: Proton pump inhibitor.
Pharmacokinetics :
Distribution: The apparent volume of distribution at steady state in healthy subjects is approximately 0.22 L/kg body weight. Esomeprazole sodium is 97% bound to plasma proteins. Metabolism and Excretion: Esomeprazole sodium is completely metabolised via the cytochrome P450 (CYP) system. The major part of the metabolism of Esomeprazole sodium is dependent on the polymorphic CYP2C19 enzyme, which forms the hydroxy and desmethyl metabolites of Esomeprazole sodium. The remainder of metabolism is dependent on another specific isoform, CYP3A4, to form Esomeprazole sodium sulphate, the major plasma metabolite. Total plasma clearance is approximately 17 L/hour after single dosing and about 9 L/hour after repeated dosing. The plasma half-life is approximately 1.3 hours after repeated once-daily dosing. Concentration and exposure time (AUC) increased after repeated administration of Esomeprazole sodium.
2. What are the uses of Omic-20 capsules?
The drug is indicated for the following cases:
Gastroesophageal reflux disease (GERD): erosive reflux esophagitis, long-term treatment for patients with healed esophagitis to prevent recurrence, Symptomatic treatment of gastroesophageal reflux disease (GERD), acid-related digestive disorders, prevention of acid aspiration into the respiratory tract during anesthesia. Zollinger-Ellison syndrome. In combination with an appropriate antibacterial regimen for eradication of Helicobacter pylori and healing of Helicobacter pylori-infected duodenal ulcers and prevention of peptic ulcer recurrence in patients with Helicobacter pylori-infected ulcers. Prolonged treatment after intravenous prophylaxis of peptic ulcer rebleeding. Treatment of Zollinger Ellison syndrome In combination with antibiotics in the treatment of duodenal ulcers caused by Helicobacter pylori.
3. Omic-20 capsules side effects
The following drug-related adverse reactions have been reported or suspected in clinical studies of esomeprazole:
Common: Headache, abdominal pain, diarrhea, flatulence, nausea/vomiting, constipation fertilizer. Uncommon: Dermatitis, pruritus, urticaria, dizziness, dry mouth. Rare: Hypersensitivity reactions such as angioedema, anaphylaxis, elevated liver enzymes. The following adverse reactions have been reported for the racemic mixture (omeprazole) and may occur with esomeprazole:
Central and peripheral nervous system: Paresthesia, somnolence, insomnia, dizziness. Reversible mental confusion, agitation, temper, depression, and hallucinations mainly in critically ill patients. Endocrine: gynaecomastia. Gastrointestinal: Stomatitis and gastrointestinal candidiasis; Hematology: leukopenia, thrombocytopenia, agranulocytosis and pancytopenia. Liver: elevated liver enzymes, encephalopathy in patients with previous severe liver disease: hepatitis with or without jaundice, liver failure. Musculoskeletal: Joint pain, muscle weakness and myalgia. Skin: Rash, erythema multiforme photosensitivity, Stevens-Johnson syndrome toxic epidermal necrolysis (TEN), alopecia. Other adverse reactions fatigue, hypersensitivity reactions such as angioedema, fever, bronchospasm, interstitial nephritis. Increased sweating, peripheral edema, blurred vision, taste disturbance and hyponatremia.
4. Adverse drug interactions of Omic-20 capsules
Esomeprazole inhibits CYP2C19, the main enzyme that metabolizes esomeprazole. Therefore, when esomeprazole is co-administered with drugs metabolised by CYP2C29 such as diazepam, citalopam, imipram, imipramine, clomipramine, phenytoin, etc., plasma concentrations of these drugs may be increased and dose reduction may be required.
5. How to use Omic-20 capsules effectively?
For patients with Zollinger-Ellison syndrome: 60mg per day Patients with duodenal ulcer: take the drug from 0.5 to 1 month, 20mg per day Patients with gastric ulcer, reflux esophagitis: use medicine for 1 to 2 months, 20mg per day. In case the patient does not respond to other treatments, the dose can be increased to 40mg. Dosage to prevent recurrence of gastric and duodenal ulcers: 20-40mg per day for oral medication to have the most optimal effect. During the course of treatment, patients should adhere to the indications, not arbitrarily increase or decrease the dose. Please inform your doctor if you have chronic diseases such as cardiovascular disease, allergies... for advice and to change the dose if necessary. When you overdose, forget the dose and how to handle it
Symptoms: usually patients with overdose often have gastrointestinal symptoms, health decline, weakness
Treatment: monitor the patient's symptoms . Timely treatment of symptoms is very necessary for patients with overdose, then take the patient to the nearest medical facility for treatment
6. Be careful when using Omic-20 capsules
Women who are pregnant or during lactation are subject to erratic physiological system changes. Therefore, it is necessary to consult a doctor before using it for this person. Because the drug does not cause drowsiness and does not affect the nervous system, it can be used for drivers, operating machinery, and doing heavy work. Food or drink containing alcohol or stimulants can affect how the medicine works. Therefore, it is necessary to minimize these items. Note:
With drugs that have expired or appear strange on the drug such as mold, drug color change, watery, do not continue to use. Do not leave the medicine near the place where children play, to avoid the case that children can play and accidentally drink.
7. Preservation of Omic-20 capsules
Store Omic-20 capsules at a temperature below 30 degrees Celsius. Store the medicine in a cool, dry place, avoid direct sunlight, keep out of reach of children.
In summary, Omic-20 capsules are drugs that treat diseases of the gastrointestinal tract such as gastroesophageal reflux, duodenal ulcer and benign stomach. Patients should carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy medicine to treat at home because there may be unwanted side effects.
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