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Mometasone furoate is indicated in the treatment of conditions such as asthma, allergies or skin diseases. However, Mometasone furoate can also cause some unwanted side effects. Therefore, before using the drug, you need to learn carefully and be prescribed by your doctor.1. What is Mometasone?
Mometasone furoate belongs to the group of synthetic glucocorticoid drugs with good anti-inflammatory activity. Corticosteroids are effective in inhibiting cell types such as mast cells, leukocytes, eosinophils, neutrophils, macrophages, or lymphocytes, or mediators such as histamine, eicosanoids, leucotrienes, and cytokines. . These compounds have been linked to inflammation and asthma. Leukocytes and macrophages may assist in the initiation of drug responses through these mediators. Mometasone furoate has the ability to inhibit the attachment of leukocytes in the damaged vessel wall. It then prevents inflammatory cells from migrating to the damaged area, constricting the vessels and reducing the permeability of blood vessels. At that time, it will prevent inflammatory cells from reaching the site of injury.Mometasone furoate is a corticosteroid used in the following forms:
Topical cream with a concentration of 0.1% cream combined with 0.1% ointment, 0.1% ointment Mometasone furoate Mometasone furoate medicine in the form of a spray through the use of a spray by mouth with a concentration of 110 micrograms equivalent to one spray of Mometasone furoate nasal spray with a spray suspension with a concentration of 0.05% equivalent to 50 micrograms of Mometasone furoate per spray. When giving Mometasone furoate into the body by nasal spray, no compounds of the drug were detected in plasma. But using the drug in the form of ointment or cream can absorb the whole body of Mometasone furoate with 0.7% and the absorption is increased when using a occlusive dressing. With Mometasone furoate by mouth, the absorption of Mometasone furoate is less than 1%.
Mometasone furoate can bind to proteins from 98 to 99%. Mometasone furoate is metabolised in the liver via CYP3A4 and to a metabolite. However, Mometasone furoate and its metabolites are eliminated in the faeces, bile, and urine.
2. Indications and contraindications to the use of Mometasone furoate
2.1. Indications Mometasone furoate is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients over 2 years of age. This medicine may be used to treat the symptoms of seasonal allergic rhinitis or to prevent seasonal allergic rhinitis. Cases of nasal polyps in adults. Use in asthma maintenance therapy to prevent or supplement asthma when corticosteroids are needed to reduce or eliminate the need for oral corticosteroids. 2.2. Contraindications Mometasone furoate drug is contraindicated for people with hypersensitivity to the components of the drug Do not use the drug for the treatment of patients with acute bronchospasm in the asthmatic state or in children under 4 years of age. Mometasone furoate is also contraindicated for facial rosacea or acne, perioral dermatitis, skin atrophy, pruritus around the anus and genitals, impetigo, milia, or herpes or parasitic infection. bacteria and fungi, tuberculosis, syphilis. Mometasone furoate should not be used in open wounds or on skin sores.3. Dosage and usage of the drug Mometasone furoate
3.1. For adults Treatment of asthma with initial dose for adults and adolescents over 12 years of age use single dose in combination therapy with bronchodilators or can be used in combination with inhaled corticosteroids at a strength of 220 micrograms /day in the evening. In case asthma does not improve after two weeks of treatment with the initial dose, a higher dose can be used to control the disease, the maximum recommended dose for patients is 440 micrograms per day and used in the evening. . Use of oral inhalation therapy in patients receiving systemic corticosteroids: When using this therapy, the asthmatic patient must be relatively stable before starting the oral spray. First, administer Mometasone furoate spray concurrently with a maintenance dose of systemic corticosteroids. Thereafter, reduce the dose of systemic corticosteroids at least 1 week after initiating Mometasone furoate by mouth and do not reduce the daily dose by more than 2.5 mg of prednisone per week. Allergic Rhinitis: A nasal spray is used to treat seasonal allergic rhinitis. The usual dose for adults is 100 micrograms in the nose per day. For the prophylaxis of seasonal allergic rhinitis in adults with seasonal allergens, the dose of Mometasone furoate is 200 micrograms daily and is initiated 2 to 4 weeks before the expected onset of pollen season. Nasal polyposis is treated with Mometasone furoate at a dose of 100 micrograms into each nostril twice daily, equivalent to a total daily dose of 400 micrograms. Mometasone furoate topical use Mometasone furoate cream and ointment is used topically in thin patches and applied to the affected areas. Patients usually apply it twice a day. As for the anointing form, you can put a few drops of Mometasone furoate on the affected area once a day and then use your hands to gently massage. Note that Mometasone furoate should not be used with a occlusive dressing.
3.2. For children Mometasone furoate oral spray For asthma treatment in children 4 to 11 years of age with a maximum initial dose of 110 micrograms and used once a day in the evening.
Using Mometasone furoate nasal spray Treatment of allergic rhinitis for children 12 years of age and older at a dose of 100 micrograms into each nostril per day for a total daily dose of 200 micrograms. For children from 2 years old to 11 years old, use a dose of 50 micrograms per nostril per day for a total dose of 100 micrograms
Prophylaxis of allergic rhinitis in children over 1 year of age with seasonal allergies using a dose of 200 micrograms every day and starting 2 to 4 weeks before the expected start of the pollen season.
The dosage of Mometasone furoate above is for reference only. Therefore, if you use the drug to improve your health, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember. However, if the missed dose of Mometasone furoate is close to your next dose, skip the missed dose and take the next dose. You should be careful not to double the dose of Mometasone furoate, because this can cause bad symptoms affecting health.
In case of drug overdose, stop using and see a doctor for timely support.
4. Undesirable side effects of Mometasone furoate drug
Mometasone furoate medicine can cause common unwanted side effects such as headache, pain, depression, fatigue, musculoskeletal pain, back pain, rhinitis, upper respiratory tract infection, sore throat. , nosebleeds, abdominal pain, loss of appetite, dry mouth, flatulence, gastroenteritis, otitis media, conjunctivitis, viral infections...However, some people may experience side effects. Rare side effects such as angioedema, nasal candidiasis, nasal septum perforation, mycosis, folliculitis, HPA axis inhibition, paresthesia, depigmentation...Mometasone furoate drug interacts with other drugs such as drugs. Inhibits CYP3A4 isoenzyme because mometasone furoate is metabolised in the liver by cytochrome P450 isoenzymes. Concomitant use of the drugs may produce potent inhibitors leading to increased plasma concentrations of mometasone furoate.
To use the drug Mometasone furoate, you need to consult with your doctor. Also, always tell your doctor what medications you are taking to avoid drug interactions.
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