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Medisamin medicine contains the ingredient tranexamic acid, which belongs to the group of derivatives of the amino acid lysine. The drug has been shown to stop bleeding in some patients after undergoing surgery.
1. Effects on patients of Medisamin 500mg
In Medisamin medicine contains the ingredient is tranexamic acid in the group of derivatives of the amino acid lysine. This substance has the ability to prevent Plasminogen and plasmin from combining with Fibrin. But the inhibitory ability of drugs with plasmin is quite weak, they prevent the production of plasmin mainly by inhibiting the conversion of plasminogen into this substance. Therefore, the drug will assist in stopping bleeding and stabilizing blood clots.
Because of its ability to stop bleeding and stabilize blood clots, Medisamin 500mg is often used for the following cases:
Hemostasis after tooth extraction with patients with difficulty in clotting New patients Prostate surgery, Use of hemostasis after hysterectomy. In addition, some other problems such as menstrual periods longer than usual, hereditary swelling of the veins and bleeding when using fibrinolytic drugs will also use this drug to stop bleeding.
2. Instructions on how to use Medisamin 500mg properly
Medisamin according to the instructions can be used before or after meals. Because of its pharmacological properties, the patient should swallow the tablet whole without chewing or breaking it. Each tablet has a dosage of 500 mg, so it will be considered by the doctor to be suitable for each patient.
2.1 Adults When the body appears to have high fibrin consumption, the drug should be used at a dose in the range of 15-25mg/kg body weight. Dosage will vary depending on body weight. Calculate the appropriate dose and divide it into 2-4 doses a day.
Patients who have recently extracted teeth, if there are signs of difficulty holding the device, will use it 3-4 times a day. The total dose will be calculated based on weight and every 1 kg corresponds to 25mg. Your doctor will prescribe it one day before surgery. Then according to the condition that the dose lasts from 2 to 8 days.
Women with abnormally long menstrual cycles should use the pill from the fourth day of the cycle. Dosage is usually 2 tablets / time and 3 times a day. If the condition does not improve, the dose can be increased up to a maximum of 4 g/day.
People with swollen veins will use 2-3 tablets / day, maintain use 3 times. When you have a nosebleed, your doctor will probably prescribe the drug with a dose of 2 tablets for each time and taken 3 times a day. Nosebleed patients will be used for 1 week and carefully monitor the body's manifestations.
2.2 Young children Children are the subjects that limit the use of drugs as much as possible. Due to the weakness of the body, the drug should only be used when directed and prescribed by a doctor. Dosage for children will be calculated according to 25mg/kg of total body weight, divided equally into 2 - 3 times per day.
2.3 Elderly people with or without kidney failure The elderly or patients with kidney failure will have a flexible treatment regimen. Their dosage is often rebalanced to best suit their current condition at that time. If the creatinine clearance rate changes, the dose will be adjusted according to:
Body elimination in the range of 50 - 80 ml per minute reduced by 50% with the previous dose The body eliminated in the range of 10 - 50 ml per minute decreased 75% with previous dose The body excretes less than 10 ml per minute 90% of the previous dose With the group of patients adjusted dose based on serum creatinine concentration (SCC) will be as follows:
When SCC index fluctuates in the range of 120 to 250 micromol / L, the patient takes the drug 2 times / day and the amount of medicine is calculated according to the rate of 15mg / kg When the SCC index fluctuates in the range of 250 to 500 micromol / L the patient Taking the drug once a day and the amount of medicine calculated based on the rate of 15mg/kg When the SCC index fluctuates above 500 micromol/L, the patient will be adjusted according to 2 options: orally at the rate of 15mg/kg for 2 days or 7.5mg/kg per day. The first dose will be taken once and given for 2 days and the second dose is taken once a day.
3. The plan to handle when taking the wrong dose of medicine
When using the drug if it is not in accordance with the prescribed dose, it will be very dangerous to health and affect the use of the inherent drug. In case of forgetting, it can be taken immediately, if the delay is short. If you have forgotten and found out when you need to take your next dose, the missed dose will be skipped. Most medicines recommend that you do not take a double dose if you miss it, as that will cause a decrease in the effectiveness of the drug.
Patients who take an overdose will have or do not have unusual signs. According to statistics, the most common signs of overdose appear to be nausea and a sudden drop in blood pressure while standing. In case the patient accidentally overdoses, the patient should be taken to the hospital for examination and early evaluation for timely support.
4. Who should not use Medisamin 500 mg
The main function of the drug is to stop bleeding, so most patients can use it. However, after some analysis and clinical evaluation, there is a part of drug use that will be dangerous such as:
Patients with a history of hypersensitivity or allergy to any ingredient of the drug will not be recommended to use. or change drugs with the same effect People who have had a stroke, heart attack, blood vessel blockage or are at risk of blood clots Patients who are color blind Patients diagnosed with severe kidney failure
5. Side effects and interactions of Medisamin
Based on the statistical results of clinical studies, Medisamin may cause some side effects while using. The most common is that the patient may have digestive disorders leading to diarrhea, nausea or abdominal pain. These side effects will all be reduced if the dose is adjusted accordingly. In addition, a few research results have reflected some of the symptoms that will occur when taking the drug such as:
Blood vessel blockage or sudden drop in blood pressure Dizziness, dizziness, hydrocephalus or cerebral infarction .... Decreased platelet count Abnormal clotting time, disordered clotting process Vision loss, color blindness syndrome.. Skin rash... These symptoms should be Pay attention and notify your doctor soon for the best treatment advice.
Medisamin drug interactions can cause blood clots if you are taking hormonal contraceptives. In the worst case, it will lead to stroke, heart failure, kidney failure... Accompanied by symptoms such as chest pain, vomiting blood with cough, blood in urine, swelling and pain in extremities, vision loss. ..
For people with high blood pressure, high cholesterol levels and a habit of smoking, there is a risk of blood clots. When blood clots form, the severity is pushed up. If not promptly reported to the doctor will affect the speed of blood circulation and can cause death.
According to analysis, the drug has the ability to penetrate the fetus if used by pregnant women. In experiments with animals, after using the drug, the fetus will be born with deformities. Women who are breast-feeding should also be aware of the presence of the drug in breast milk at low concentrations.
Medisamin 500mg is difficult to use for children because it requires taking the whole tablet. In addition, this drug has the ability to stop bleeding but has too many dangerous side effects. You should not buy and use drugs on your own unless under the direction and supervision of a specialist.
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