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Omeprazole is a familiar drug name for people with peptic ulcer disease or gastroesophageal reflux disease. The active ingredient Omeprazole is in the drug Lomec 20. So how is Lomec 20 indicated and what should be the treatment process?1. What is Lomec 20?
Lomec 20 ingredients include the active ingredient Omeprazol 20mg and some excipients such as Lactose anhydrous, Hypromellose, Hydroxypropyl Cellulose, Sodium lauryl sulfate, Disodium Phosphate Dodecahydrate, Hypromellose phthalate, Diethyl phthalate, Sugar spheres
Lomec 20 preparations hard blue capsule, containing enteric coated microcapsules. Packing specification for each box of 4 blisters, each blister contains 7 capsules.
2. Pharmacological characteristics of the drug Lomec 20
2.1. Pharmacodynamics The active ingredient Omeprazole in Lomec 20 inhibits gastric acid secretion through reversible inhibition of the H+/K+/ATP enzyme system (also known as proton pumps) in the parietal cells of the stomach. .
The proton pump inhibitory effect of Lomec 20 is fast, long-lasting but reversible, and at the same time, Omeprazole does not act on Acetylcholine or Histamine receptors. The drug Lomec 20 reaches its maximum effect after 4 days of taking the drug.
2.2. Pharmacokinetics Lomec 20 is completely absorbed in the small intestine 3 to 6 hours after oral administration. Bioavailability is about 60% and food does not affect the absorption of the drug. The absorption of Omeprazole is dose dependent, it should be noted that Lomec 20 may spontaneously increase absorption and bioavailability by inhibiting gastric acid secretion.
Lomec 20 is highly bound to plasma proteins (about 95%) and is widely distributed in tissues, especially in gastric parietal cells. The bioavailability of Lomec 20 oral for the first time is approximately 35%, but increases to 60% as the patient continues to take the same daily dose. Although Lomec 20 has a short half-life (about 40 minutes), the inhibitory effect on acid secretion is long, so it can be used once a day. Omeprazole is almost completely metabolized in the liver, then Excreted rapidly and mainly in the urine (80%), the rest is excreted in the feces. The metabolites of Omeprazole are inactive, but interactions with many other drugs occur due to their ability to inhibit cytochrome P450.
The pharmacokinetics of Lomec 20 were not significantly changed in the elderly or in patients with renal impairment. In patients with impaired liver function, the bioavailability of Lomec 20 is increased and clearance is decreased. However, the accumulation of drugs and metabolites in the body has not been recorded.
3. Indications of the drug Lomec 20
Indications to use Lomec 20 in the following cases:
Peptic ulcer; Gastroesophageal reflux; Zollinger-Ellison syndrome.
4. Instructions for using Lomec 20
In order to increase the therapeutic effect of Lomec 20, a very important factor is that the stomach ulcer must be healed for a long time and avoid recurrence, and at the same time, it is necessary to completely eliminate Helicobacter pylori or limit/discontinue its use. non-steroidal anti-inflammatory drugs.
Recommended dose of Lomec 20 :
GERD esophagitis: The recommended dose is 20-40mg (1 to 2 Lomec 20 tablets), taken once a day for 4 to 8 weeks, followed by maintenance therapy at 20mg once daily; Treatment of ulcers: It is recommended to use 1 time / day, 1 tablet Lomec 20 each time (in severe cases, 2 tablets can be used) for a period of 4 weeks with duodenal ulcer and 8 weeks with gastric ulcer. Patients should not take Lomec 20 for longer than the recommended time. The use of Omeprazole reduces gastric acidity, but stimulates a temporary and reversible increase in gastrin secretion. Oral dose of 20mg Omeprazole reduces HCI generation within 2 hours, when taking 1 dose per day continuously, the maximum effect will be achieved after 3-5 days; The first dose of Omeprazole 20mg has been effective in reducing symptoms, and most patients with gastric ulcer and reflux esophagitis need an average of 4 weeks for the ulcer to heal. However, the recurrence rate will be high if H.pylori is not completely eradicated and NSAID use is not reduced or stopped; Use of Lomec 20 in H. pylori eradication regimen: Omeprazole requires a combination of drugs in a 2- or 3-drug regimen, including proton pump inhibitors, antibiotics, and antacids. The most commonly used regimen is a combination of Lomec 20 with antibiotics Amoxicillin (or Tetracycline) and Metronidazole (or Tinidazole) for 10 days. The 3-drug regimen usually causes more undesirable effects than the 2-drug regimen, but in both cases the undesirable effects are mild; Treatment of Zollinger-Ellison syndrome: 60mg Omeprazole once a day, equivalent to 3 Lomec 20 pills (varying from 20 to 120mg/day), in case of higher dose 80mg need to be divided into 2 times/day; Patients with hepatic impairment: The bioavailability and half-life of Lomec 20 may be increased in this population. Therefore, the maximum recommended daily dose for patients with hepatic impairment is 20 mg.
5. Contraindications of the drug Lomec 20
Do not use Lomec 20 for people with a history or sensitivity to Omeprazole, other PPIs or any excipients in the drug.
6. Some warnings and cautions when using Lomec 20
Before giving Lomec 20 to people with peptic ulcers, doctors need to rule out the possibility of malignancies because Omeprazole can mask symptoms and lead to a late diagnosis of cancer. As with other proton pump inhibitors, Lomec 20 should be used with caution in patients with impaired hepatic function and requires an appropriate dose adjustment. The drug Lomec 20 in the experiment did not record the possibility of causing malformations and toxicity to the fetus, but should not be used for pregnant women, especially the first 2 months of pregnancy. Lomec 20 should not be used in nursing mothers. There are no research papers that come to a specific conclusion on this issue. Lomec 20 can cause drowsiness, dizziness, so it should be used with caution when using drivers and operating complex machines.
7. Side effects of the drug Lomec 20
Some common side effects when using Lomec 20:
Headache, drowsiness, dizziness; Digestive disorders such as nausea, vomiting, abdominal pain, constipation, bloating. Some less common problems of Lomec:
Insomnia, sensory disturbances, dizziness, fatigue; Skin urticaria, itching, rash; Temporary increase in liver enzymes; Sweating sweat; Peripheral edema; Hypersensitivity manifestations include angioedema, shock, and anaphylaxis; Decrease in the number of white blood cells, platelets or total blood cells; Reversible confusion, agitation, depression, hallucinations in the elderly; Hearing disorders; gynecomastia in men; Candida infection ; Hepatitis with or without jaundice, hepatic encephalopathy; Bronchospasm; Joint pain, muscle pain; Interstitial nephritis. Lomec 20 ingredients include the active ingredient Omeprazole 20mg and some excipients indicated for the treatment of a number of gastrointestinal diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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