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Serapid drug contains flunarizine ingredient together with excipients and capsules, indicated in the prophylaxis of migraine attacks, or symptoms of dizziness due to vestibular disorders. However, the drug Serapid can cause some unwanted side effects for users such as: dizziness, dizziness, even prolonged use of the drug may experience depression. Therefore, you need to learn carefully before using the drug and should consult a treating doctor.1. Mechanism of action of the drug Serapid
What is Serapid? Serapid contains flunarizine which belongs to the group of selective calcium antagonists with the ability to bind Calmodulin. This binding process helps prevent cellular calcium overload. Moreover, the active ingredient FLunarizin in Serapid also has anti-histamine H1 activity. Therefore, flunarizine is effective in the prevention as well as in the treatment of migraine and vertigo of central and peripheral origin.Serapid drug, when absorbed into the body, is well absorbed from the intestinal tract and reaches peak plasma concentrations within 2 to 4 hours. This state is usually stable at 5 and 6 weeks. After the drug is completely metabolised in the liver, Serapid and its metabolites are excreted in the faeces by the biliary tract. The terminal half-life of Serapid is about 18 days and Serapid is 90% protein bound.
2. Indications and contraindications to the use of Serapid
What diseases does Serapid treat? Serapid is indicated for the prophylaxis of classic migraine with aura, or regular migraine without aura. In addition, Serapid is also used in the symptomatic treatment of vestibular vertigo due to vestibular system dysfunction. Or treat symptoms caused by cerebral circulatory insufficiency and brain cell hypoxia including: Dizziness, headache caused by vascular or arousal disorders, memory loss, or poor concentration may even have a sleep disorder. Or use Serapid drug in the treatment of muscle spasticity when walking or lying down, paresthesia, cold extremities.Serapid drug is contraindicated in cases with a history of hypersensitivity to the ingredients of the drug, or in cases where the patient has a history of depression, Parkinson's disease or extrapyramidal disease, or those with low blood pressure, heart failure. kidney,...
3. Dosage and usage of Serapid
Treatment of migraines Serapid 5mg is indicated for the treatment of adults for migraine prevention: The dosage used for these cases is usually 5mg/day and is taken in the evening every day. Maintain this therapy for 4 to 8 weeks. During treatment with Serapid, if depressive or extrapyramidal symptoms or serious adverse events affecting the patient's health occur, the drug should be discontinued. In the event that after 8 weeks of treatment, the patient does not feel an improvement in the patient's condition, it can be considered that this case is not responding to the drug and the drug should be discontinued. For prophylactic treatment of migraine with Serapid, it should be done for no more than 6 months.In the case of patients under the age of 65 whose clinical manifestations indicate an inadequate response to drug therapy, the patient's dose may be increased up to 10 mg/day. However, when increasing the dose for patients, doctors need to carefully consider the patient's tolerance to the drug.
Treatment of migraine in children: For children over 12 years old, especially those with undiagnosed cases of migraine, can use a dose of 5mg / day and take it in the evening. The duration of treatment for children should not exceed 6 months. As for children under 12 years of age, there is not enough evidence on the effectiveness and safety of the flunarizine component in Serapid. Therefore, there is no recommendation to use the drug for these subjects.
Treatment of dizziness Treatment of cases of vertigo is used at the same dose as for migraine treatment, but the initiation of treatment should not be prolonged. The duration of treatment until symptoms are controlled is usually less than 2 months.
Even if there is no significant improvement after 1 month of co-treatment for chronic vertigo, two months for orthostatic vertigo, the patient can be considered as non-responsive to treatment and medication should be discontinued.
The dosage of Serapid furoate above is for reference only. Therefore, if you use the drug to improve your health, you need to learn carefully and consult a doctor.
If you forget to take your medicine, use it as soon as you remember. However, if the missed dose of Serapid furoate is close to your next dose, skip the missed dose and take the next dose. You should be careful not to use double the dose of Serapid furoate, because this can cause bad symptoms affecting health.
In case of drug overdose, stop using and see a doctor for timely support.
4. Unwanted side effects when using Serapid
Serapid drug can cause some side effects for patients during treatment:Undesirable reactions caused by Serapid drug usually include belching, vomiting, nausea, abdominal pain, insomnia, boredom. eating, dry mouth, muscle pain and skin rash. In addition, patients may experience weight gain when using drugs containing the ingredient Flunarizine. Depressive symptoms accompanied by a feeling of apathy or lethargy or extrapyramidal reactions such as tremor, muscle rigidity, and dyskinesia have also been reported in patients who have used flunarizine-containing drugs for a period of time. treatment. However, extrapyramidal reactions are more common in the elderly, and depression is also more common in this age group. Therefore, for the elderly, it is often recommended not to overdose and check your health regularly during treatment with the drug. Extrapyramidal symptoms with slow movement, rigidity, sitting or lying down, or dyskinesia, tremor of limbs. Gastrointestinal: Burning sternum can cause nausea, stomach pain. Central Nervous System: Drowsiness, anxiety,... Precautions when using Serapid
Serapid drug containing flunarizine can trigger extrapyramidal and depressive symptoms or even Parkinson's symptoms in people over the age of 65. Therefore, when patients are over 65 years old. At this age, drug use should be carefully considered and closely monitored during use. The drug is likely to accumulate in the body if higher than recommended doses are used. This can increase the chance of unwanted side effects. Patients should note not to use the drug in excess of the recommended dose and should monitor their health periodically to quickly detect if extrapyramidal symptoms or depression occur. From there, it is possible to promptly stop using the drug to avoid risks affecting the patient's health. Some cases of patients with pain with increasing severity may be due to one of the causes of using Serapid containing Flunarizine ingredient. If this occurs, the patient should stop taking the drug immediately. Drug Interactions:
Serapid may increase lactation when used with oral contraceptives during the first two months of treatment with Serapid containing Flunarizine. Or, when used concurrently with tricyclic antidepressants, alcohol or other central nervous system depressants, there is an effect of increasing the drug's depressive status.
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