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What disease does Hafenthyl 145mg treat? is a question many people have. Hafenthyl is used to treat dyslipidemia of various types. The safe use of the drug will help the drug achieve the highest therapeutic effect.
1. What is Hafenthyl 145mg?
Hafenthyl 145mg drug includes the main drug is Fenofibrate and other excipients. It is used in the treatment of dyslipoproteinemia types IIa, IIb, III, IV and V in people who have not responded to diet and other non-pharmacological therapies.
1.1. On the pharmacodynamics of Hafenthyl Active ingredient Fenofibrate, also known as a derivative of fibric acid, is a lipid-lowering drug mediated through interaction with the peroxisome proliferation-activating receptor (PPAR). Fenofibrate also has the effect of reducing blood uric acid in normal people and people with hyperuricemia caused by increasing uric acid excretion through the urine.
1.2. On the pharmacokinetics of the drug Hafenthyl Absorption: The active substance Fenofibrate is well absorbed from the gastrointestinal tract. Maximum plasma concentrations (Cmax) are reached 2 to 4 hours after dosing. Plasma drug concentrations were stable with continuous long-term treatment in all individuals. Distribution: 99% of the active substance Fenofibrate in the blood is bound to plasma proteins. Metabolism: Following oral administration of Hafenthyl, the active substance Fenofibrate is rapidly hydrolysed by esterases to the active metabolites fenofibric acid, mainly conjugated with glucuronic acid. Fenofibrate is not metabolised through the liver microsomes. No unmetabolized form was found in plasma. Elimination: Fenofibrate is eliminated mainly in the urine (60%) in the form of metabolites and faeces (approximately 25%) of all hafenthyl is eliminated within 6 days.
2. What disease does Hafenthyl 145mg treat?
Hafenthyl is indicated in the treatment of the following conditions:
Hypercholesterolemia (type IIa), isolated endogenous hypertriglyceridemia (type IV), combined hyperlipidemia (type IIb and III) after applying using the right regimen and appropriate diet but not effective. Secondary hyperlipoproteinemia, persistent despite treatment of the cause (eg, dyslipidemia in diabetes). The diet that has been applied before treatment must still be continued.
3. Usage and dosage of Hafenthyl
3.1. How to use Hafenthyl Hafenthyl is taken orally. The time to use the drug can be at any time of the day, during meals, after or before meals.
You should swallow the tablet whole with a glass of water, do not crush the tablet.
3.2. Dosage of Hafenthyl The dose and duration of Hafenthyl are decided by the treating doctor.
According to the manufacturer's recommendations, the usual dose is as follows
For adults:
Hafenthyl 100 mg tablets: 3 tablets/day; Hafenthyl tablets 300mg, 200mg and 160mg: 1 tablet/day. For children older than 10 years: up to 5 mg/kg/day.
4. Undesirable effects of the drug Hafenthyl
As is the case with other fibrates, muscle damage (diffuse myalgia, tenderness, weakness) as well as exceptional cases of muscle wasting, sometimes severe. However, this side effect usually goes away soon after stopping the drug completely. Some other undesirable effects, which are less common and milder, have also been reported such as dyspepsia, increased transaminases, skin reactions such as erythema, pruritus, urticaria, and sensitization. with rare light. However, many cases of long-term use of the drug still have no side effects at all. When there are abnormal manifestations during treatment with Hafenthyl, it is necessary to immediately notify the treating doctor.
5. Hafenthyl drug interactions
Anticoagulants, oral (warfarin): Causes prolongation of PT/INR: Anticoagulant dose reduction (approximately one-third of initial dose and subsequent dose adjustment as necessary) is required. Pay attention to periodically monitor PT/INR until stable. HMG-CoA reductase inhibitors and other fibrates: The risk of serious muscle toxicity is increased when Hafenthyl is co-administered with HMG-CoA reductase inhibitors or other fibrates. Bile acid binding resins (cholestyramine, colestipol): When combined with Hafenthyl, it reduces the absorption of the active ingredient Fenofibrate Cyclosporin: Increased risk of nephrotoxicity or impaired renal function. Do not combine Hafenthyl with hepatotoxic drugs (MAO inhibitors, perhexiline maleate, ...) with the active ingredient Fenofibrate. Like other fibrates, fenofibrate stimulates mitochondrial multifunctional oxidizing enzymes involved in fatty acid metabolism in rodents and may interact with drugs metabolized by these enzymes. When using the drug Hafenthyl, you should inform your doctor about the drugs you are using so that the doctor can advise you to avoid unwanted interactions.
6. Some notes when using Hafenthyl
6.1. Contraindications to use Hafenthyl Hypersensitivity or hypersensitivity to the active substance Fenofibrate or any of its ingredients. Liver failure (including biliary cirrhosis and long-term abnormal liver function with no identifiable cause). Severe renal failure (eGFR < 30 ml/min/1.73 m2). Diseases related to the gallbladder. Children, pregnant women and lactating women. History of photosensitization or photosensitization or phototoxicity during treatment with fibrates or ketoprofen. Acute or chronic pancreatitis, except in cases of acute pancreatitis caused by severe hypertriglyceridemia. 6.2. Attention to Special Populations Ability to Drive and Use Machines: Fenofibrate has no or negligible influence on the ability to drive and use machines. Pregnancy: Hafenthyl should not be used in pregnant women. Laboratory studies in animals have shown no teratogenic effects. However, experiments have also shown that there are signs of fetal toxicity at doses toxic to the mother animal. However, the potential hazard to humans has not yet been identified. Lactation: There are no data on the excretion of fenofibrate or its metabolites in human milk. However, for safety reasons, it is not recommended for use by nursing women.
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