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Cholinaar belongs to the group of psychotropic drugs that are prepared in the form of an injectable solution. The main ingredient of Cholinaar is citicolin indicated in the treatment of acute phase of traumatic brain injury with impaired consciousness.
1. Mechanism of action of the drug Cholinaar
Cholinaar drug has the main ingredient is citicoline, which belongs to the group that stimulates the biosynthesis of phospholipids on nerve cell membranes. This compound can decrease glutamate levels in the brain and increase adenosine triphosphate to provide protection against ischemic neurotoxicity. In addition, this compound also helps to increase glucose metabolism in the brain and blood flow in the brain.
Accordingly, Citicoline stimulates the biosynthesis of structural phospholipids of the neuronal membrane and improves the function of the carrier mechanism with the action of ion exchange pumps as well as the input and integral receptors in nerve transmission. Citicoline also helps preserve nerve cell energy reserves, inhibit apoptosis and stimulate acetylcholine synthesis.
For patients with traumatic brain injury, this compound helps to speed up recovery and reduce the duration and intensity of the post-traumatic syndrome.
2. Indications and contraindications for the use of Cholinaar
Cholinaar is indicated in the treatment of acute phase of severe traumatic brain injury with impaired consciousness or cerebrovascular accident, cerebral hemorrhage, cerebral palsy, traumatic brain injury. Besides, the drug is used in the treatment of cerebrovascular accidents such as primary degenerative dementia, dementia due to multifocal infarction, sequelae of cerebrovascular accident, traumatic brain injury, and Alzheimer's disease. parkinson .However, Cholinaar drug may also be contraindicated in cases of hypersensitivity to the ingredients of Cholinaar drug. Or cases with increased parasympathetic nervous system tone.
3. Dosage and how to use Cholinaar
Cholinaar is used as an emergency IV injection and IM injection in cases such as the acute phase of the recommended course of treatment at a dose of 500 to 750 mg/day and the new sequelae at a dose of 500 to 750 mg/day. 250mg/day
The recommended dose is from 500 to 2000mg a day depending on the patient's medical condition and response. The duration of treatment can be about 6 weeks for acute exacerbations and 12 months for chronic cases. However, the length of treatment may depend on the severity of the disease.
In the treatment of ischemic stroke or traumatic brain injury, cerebral hemorrhage, Cholinaar should be used at a dose of 2 grams a day and divided into two times, the treatment time can be prolonged. about 6 weeks. However, this time may vary depending on the clinical response of the patient.
Note: The recommended dose of Cholinaar above is for reference only. Therefore, before using Cholinaar, patients should follow the doctor's instructions.
4. Side effects when using Cholinaar
Cholinaar can cause some unwanted side effects during treatment. However, with each case, Cholinaar side effects can occur in varying degrees from mild to severe.
Possible treatment-related reported side effects of Cholinaar are phlebitis and thrombophlebitis. The most common clinical and systemic adverse reactions may be related to the composition of Cholinaar with signs such as itching, urticaria, fever, nausea, vomiting, oral thrush, phlebitis, phlebitis, and phlebitis. block after intravenous injection, pain and inflammation at the injection site,... In some cases, more serious side effects may occur including: Eosinophilia, thrombocytopenia, thrombocytopenia, hypokalemia. blood, transient increases in serum liver enzymes, and increases in renal function parameters.
5. Notes when using Cholinaar
Some notes in the process of using Cholinaar:
For women who are pregnant and breastfeeding, caution should be exercised when using Cholinaar. Patients should be advised to use Cholinaar from their doctor, and carefully analyze the benefits and risks before using the drug. Cholinaar may change how it works as well as increase its side effects. Therefore, in order to avoid Cholinaar drug interactions, the patient should provide the doctor with a list of previously used drugs, including prescription and non-prescription drugs, herbs,... Using Cholinaar should be noted. when the manifestations of allergy to the drug Cholina. At the same time, the patient should notify the doctor so that he can promptly treat the side effects of the drug. Cholinaar should not be used with Levodopa because citicoline in this medicine can increase the effects of Levodopa. Cholinaar should not be used with medicines containing Meclofenoxate and citicoline at the same time. Above is important information about Cholinaar medicine, patients should carefully read the instructions for use and use according to the dose prescribed by the doctor to achieve the best effect.
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