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Zyrova 20 is indicated for the treatment of heterozygous and homozygous primary hypercholesterolemia, mixed dyslipidemia, primary cardiovascular disease prevention,... To better understand the use of the drug Zyrova 20, invite readers to refer to the following article.1. What is Zyrova 20?
Zyrova 20 is a cardiovascular drug, containing Rosuvastatin (Calci Rosuvastatin) 20mg and is packaged in the form of key coated tablets. Zyrova medicine 20mg is used to treat primary hypercholesterolemia or mixed dyslipidemia (type llB) and homozygous familial hypercholesterolemia. Pharmacodynamics: Rosuvastatin is a selective, competitive inhibitor of HMG-CoA reductase and catalyzes the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a cholesterol precursor. . Pharmacokinetics:
Absorption: Peak plasma concentrations of Rosuvastatin are achieved approximately 5 hours after oral administration. The absolute bioavailability is about 20%. Distribution: Rosuvastatin is widely distributed in the liver, which is the major site of cholesterol synthesis and clearance of LDL-C. The volume of distribution of Rosuvastatin is approximately 134 L. Approximately 90% of Rosuvastatin is bound to plasma proteins and mainly to albumin. Metabolism: Rosuvastatin is also rarely metabolised (approximately 10%). Rosuvastatin accounts for more than 90% of circulating HMG-CoA reductase inhibitory activity. Elimination: Approximately 90% of a dose of Rosuvastatin is also excreted unchanged in the faeces (including absorbed and unabsorbed active substances), the remainder is excreted in the urine. Linearity: Rosuvastatin exposure will be dose-proportional and concentration-timed. There were no changes in pharmacokinetic parameters after multiple daily doses.
2. What are the uses of Zyrova 20?
Rosuvastatin - the active ingredient of Zyrova 10 (Zyrova 5, Zyrova 20) will often be indicated as adjunctive therapy when patients do not respond adequately to diet and other therapies (using the drug). Other lipid-lowering, exercise, weight loss,...) aims:
Treatment of primary hypercholesterolemia (type IIa would include heterozygous familial hypercholesterolemia) or mixed dyslipidemia (type IIa will include heterozygous familial hypercholesterolemia) type IIb); Treatment is homozygous familial hypercholesterolemia; Primary dyslipidemia (type III hyperlipoproteinemia); Adults with elevated triglycerides ; Slow down the development of atherosclerotic disease; Prevention of cardiovascular events including: stroke, myocardial infarction, coronary heart disease... in patients at risk. Some other side effects of drugs that are not listed on the drug label are also approved, but your doctor may direct you to take them. You should use this medicine to treat certain medical conditions only when prescribed by your doctor.
3. Side effects when using Zyrova 20?
Common:
Headache, dizziness; Constipation, abdominal pain; Nausea; Muscle pain; Attenuate; Increased blood sugar. Rare:
Hypersensitivity reactions including angioedema; Pancreatitis and severe stomach pain; Increased liver transaminases; Myopathy and including myositis; Hemolysis; Decreased platelets. Very rare:
Amnesia; Jaundice, hepatitis; Athritis; Hematuria (blood in the urine). This list is not exhaustive of all side effects and it is possible that other side effects may occur. If you have any questions about side effects, consult your doctor or pharmacist.
4. Drug Interactions Zyrova 10 (Zyrova 5, Zyrova 20) may change the way other drugs you are taking or increase the effect of side effects. To avoid drug interactions, it's a good idea to write a list of all your current medications (including prescription, nonprescription, herbal, and dietary supplements) for your doctor or pharmacist to see. To ensure safety when taking medicine, do not arbitrarily take the drug, stop or change the dose of the drug without the permission of your doctor.
Drugs that can interact with Zyrova include:
Transport protein inhibitors; Ciclosporin; Antiviral drugs: Atazanavir, Ritonavir; Gemfibrozil and other lipid-lowering drugs: Fenofibrate, Niacin,...; Ezetimibe; Antacids containing aluminum and magnesium; Erythromycin; Anticoagulants with vitamin K antagonists: Warfarin, Coumarin, Clopidogrel; Oral contraceptives and hormone replacement therapy; Digoxin; Fusidic acid 5. How to use Zyrova 20 effectively How to use:
Zyrova 10 (Zyrova 5, Zyrova 20) is taken once a day orally. You can take it at any time of the day, before or after eating. To ensure the effectiveness of the drug, when taking you should swallow the tablet whole with a sip of water, do not chew, crush or break the medicine. Dosage:
Consider starting dose for all Asian patients at 5mg/day, then adjust dose until desired effect is achieved. The goal is to use the lowest effective dose. Treatment of hypercholesterolemia: The recommended starting dose is 5mg or 10mg once daily. If needed, your doctor may increase your dose every 4 weeks up to 20mg/day. In cases of severe hypercholesterolemia, unresponsive to 20 mg, a dose of 40 mg/day may be considered, subject to close monitoring by a physician. Prevention of cardiovascular events: The usual dose is 20mg x 1 time / day. No dose adjustment is required in elderly patients and in patients with mild to moderate renal impairment. Children:
Children under 10 years of age: the use of Zyrova and the dosage must be prescribed by a doctor. Children 10-17 years of age: Heterozygous familial hypercholesterolemia 5 to 20 mg once daily. Homozygous familial hypercholesterolemia 20 mg once daily. The maximum recommended dose in children is 20 mg/day. In case of an emergency or overdose, you need to immediately call 911 or go to the nearest local health station for timely treatment. In addition, you also need to record and bring a list of medications taken. Overdose management focuses only on symptomatic treatment and supportive measures when necessary, while monitoring liver function and creatinine kinase levels.
If you forget to take a dose of Zyrova, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Do not take 2 consecutive doses within 12 hours.
6. Caution when using Zyrova 20 In patients with a history of liver disease, as with all Statins, caution should be taken when the patient has predisposing factors for rhabdomyolysis such as renal failure, hypothyroidism, personal history or family history of hereditary muscle disease, history of muscle toxicity due to other HMG-CoA reductase inhibitors or fibrates, alcoholism, over 70 years of age, conditions causing increased blood levels of the drug, concomitant use with Fibratem.
Discontinue use if CK > 5 x ULN or severe muscle symptoms. Should not be used in the presence of sepsis, hypotension, major surgery, trauma, electrolyte disorders, endocrine disorders, severe metabolism: uncontrolled convulsions.
Store Zyrova 20 in a dry environment and at a temperature below 30°C. Avoid moisture and direct light. Keep out of reach of CHILDREN.
In summary, Zyrova 20 is indicated for the treatment of heterozygous and homozygous primary hypercholesterolemia, mixed dyslipidemia, primary prevention of cardiovascular disease. Patients need to use the drug under the guidance of a doctor to ensure safety for health.
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