Uses of Zynrelef

This is an automatically translated article.

1. What is Zynrelef?

What is Zynrelef? Zynrelef drug has the main ingredients Bupivacaine and Meloxicam, which is made for injection. With the contents of Bupivacaine/ Meloxicam equivalent to 60mg/1.8mg; 200mg/6mg; 300mg/9mg; 400mg/12mg.
Bupivacaine is a local anesthetic, with the effect of reducing membrane depolarization, blocking nerve conduction, so it has a local analgesic effect; Meloxicam is a non-steroidal anti-inflammatory drug with analgesic and anti-inflammatory effects.
Zynrelef is used to numb an area of ​​your body and relieve pain for 72 hours after surgery, including surgeries to treat foot and ankle problems, treatment in the knee joint or the abdomen or stomach.

2. How to use Zynrelef

Zynrelef is given by injection, you will be given this medication by a trained healthcare professional in the hospital.
This medicine is usually injected in the area where you had surgery and only has a local anesthetic effect in the area where you were injected. You may experience a temporary loss of sensation or movement in the injected area.
Depending on the level of pain, weight and other medical problems of the patient, different doses are prescribed.

3. Contraindications of Zynrelef

Zynrelef should not be used in the following cases:
Patients with a history of allergy to Zynrelef. Not indicated for analgesia in coronary artery bypass grafting (CABG); Patient has peptic ulcer, active gastrointestinal bleeding. As side effects of the drug include bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. Severe kidney disease; Elderly patients and patients with a history of peptic ulcer disease or gastrointestinal bleeding are at increased risk of serious gastrointestinal events. Patients should be cautious when choosing to use drugs.

4. Side effects of the drug Zynrelef

Along with these effects, Zynrelef can also cause some unwanted effects, including:
Common effects: Blurred vision; chest pain or discomfort; chills; constipation ; a cough; fever; dizzy; eyesore; headache; lightheadedness, dizziness, or fainting; muscle twitching; feeling nauseous or vomiting; pale skin; a pounding sensation in the ears; slow or irregular heartbeat; sore throat ; shortness of breath; unusual bleeding or bruising; unusual tiredness or weakness; Less common: Agitation; blistering, peeling, peeling of the skin; blood in the urine, decreased urine output; bloody or black, coffee-colored stools; See bluish lips, fingernails or palms; chest tightness ; comatose; feel confused; Dark urine; Depression; get diarrhea; hard to say; difficulty swallowing; dizziness, fainting, or lightheadedness when standing up suddenly from a lying or sitting position; double vision; heartburn; rash, itching; inability to move arms, legs or facial muscles; inability to speak; irritability; joint or muscle pain; numbness or tingling in the hands, feet, or lips; pain or discomfort in the arms, jaw, back, or neck. Other side effects: Painful or difficult urination; puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue; eye redness and discomfort; red skin lesions, often with purple centers; Have a convulsion ; shoulder discomfort, pain, or stiffness; stomach pain, cramping, or burning; ecstatic; sweat; swelling of the face, fingers, hands, feet, ankles, or legs; Inflammation; Vomiting blood or material that looks like coffee grounds; weakness or heaviness of the legs; weight gain; yellow eyes or skin; Hyperkalemia may occur when you use this medicine. Check with your doctor right away if you have stomach pain, confusion, trouble breathing, an irregular heartbeat, nausea or vomiting, nervousness easily, numbness or tingling in your hands, feet, or lips, or weak or heavy legs. than, change in heart rate; In addition to the above side effects, when you experience any other side effects, you need to tell your doctor or go to a medical facility to be checked.

5. Some things to note when using Zynrelef

Before taking this medicine you need to know the presence of other medical problems that may affect the use of this medicine, you need to tell your doctor if you have any other medical problems, especially :
Anemia ; Asthma; Bleeding problems; Blood clotting problems; Dehydration or edema; Heart attack, recent or history of or; Heart or blood vessel disease; Heart rhythm problems (eg, heart block); Hyperkalemia (high blood potassium); High blood pressure or low blood pressure; Liver failure ; stomach ulcers or bleeding; Stroke, history. Asthma sensitive to aspirin; Sensitivity to aspirin; Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Lung or breathing problems; Methemoglobinemia (blood disorder), hereditary or idiopathic should be used with caution, as may increase the risk of methemoglobinemia. Mild to moderate kidney disease or severe liver disease should be used with caution. The side effects of the drug may increase, because the drug is eliminated from the body more slowly. During the course of medication you need to have your doctor check the progress of the disease closely so that you can make sure that the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.
In addition, patients when using the drug also need to be careful:
Zynrelef when used can increase the risk of heart attack, blood clots or stroke. This is more likely in people who already have heart and blood vessel disease who use this medicine for a long time. When taken, the drug can also cause severe liver problems, increase the risk of gastrointestinal bleeding without warning signs, sometimes late detection can even be fatal. Therefore, it is necessary to closely monitor for signs of gastrointestinal bleeding or liver disease. This medicine may also cause a bone or joint problem called osteolysis. Tell your doctor right away if you have joint pain or stiffness or if you are unable to move. Using this medicine in later stages of pregnancy may harm an unborn baby. Therefore, you should tell your doctor if you are pregnant. This medication may also delay ovulation in women and may also decrease sperm count in men, which may affect both men and women's ability to have children. If you are planning to have children, talk to your doctor before using this medicine. Zynrelef can also cause a rare but very serious blood problem called methemoglobinemia. This risk may be increased in children younger than 6 months of age, elderly patients or patients with certain birth defects and is also more likely to occur in patients taking too much medication, but some Less can also occur in small amounts. The manifestation of this condition is causing cyanosis on the skin or on the nails of the patient, if there is a patient, it should be treated soon. Drug interactions c: This drug can cause interactions with many different drugs, so tell your doctor about all the medicines you are taking, especially Ketorolac; Abciximab; Aceclofenac; other anesthetic or anti-inflammatory drugs...
Zynrelef is only used under the direction and under the supervision of a qualified doctor. During and after taking the drug, you can experience many serious side effects, so it is necessary to monitor for unusual symptoms to adjust in time.
Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.