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Zyflo is a medication that is taken regularly to help reduce the frequency and severity of asthma attacks. To understand more about the use of the drug, please refer to the information about the drug through the article below.
1. What does Zyflo do?
What does Zyflo do? Zyflo medicine has 600 mg of zileuton, in the form of tablets. Zileuton is a 5-lipoxygenase inhibitor and thereby inhibits leukotriene formation (LTB 4 , LTC 4 , LTD 4 , and LTE 4 ). Leukotrienes are substances that cause many biological effects including: increased neutrophil and eosinophil migration, neutrophil aggregation, monocytes, leukocyte adhesion, increased capillary permeability pulse and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchospasm in asthmatic patients. In a study, Zileuton inhibited leukotriene-dependent smooth muscle contractions in guinea pigs and the human respiratory tract. This compound inhibits leukotriene-dependent bronchoconstriction in antigen- and arachidonic acid-challenged guinea pigs.
2. Indications and contraindications of the drug Zyflo
Indications : Zyflo is indicated for the prevention and treatment of chronic asthma in adults and children 12 years of age and older.
Contraindications
Zyflo tablets are contraindicated in patients with:
Active liver disease or elevated transaminases greater than or equal to three times the upper limit of normal Patients with known hypersensitivity to the active substance zileuton or any inactive ingredients of the drug.
3. Dosage and how to use Zyflo
How to use:
Zyflo is taken orally, you can take it with or without food. To make it easier to use, Zyflo can be taken with meals and at bedtime. You need to take the medicine on a regular basis to get the most effective treatment.
Dosage:
The recommended dose of Zyflo for the symptomatic treatment of asthmatic patients is one 600 mg tablet taken four times a day for a total daily dose of 2400 mg. In patients continuing to take prescribed medications for asthma control such as corticosteroids or bronchodilators, elevations in liver enzymes should be assessed prior to initiating Zyflo and periodically during therapy. Patients can temporarily stop the drug when there are signs of liver damage.
4. Side effects when taking Zyflo
As with other medicines, including Zyflo can cause side effects in some people. Specifically:
Some of the most common side effects are abdominal pain, upset stomach, and nausea. Less common is an increased release of substances called enzymes from the liver. Liver enzymes can be measured with a simple blood test, because even if liver enzymes are elevated, you probably won't notice any symptoms. However, some symptoms of elevated liver enzymes are feeling tired, flu-like symptoms, itching, yellow or yellow skin in the whites of your eyes, or urine that is darker than usual. In addition, you may experience sleep problems and changes in your behavior may occur while taking Zyflo.
If you notice any other symptoms that you think may be caused by Zyflo, call your doctor or seek medical attention immediately.
4. Notes when using Zyflo
Before taking the medicine, you need to talk to your doctor if you are allergic to the medicine or have ever had liver disease, hepatitis, jaundice (yellowing of the eyes or skin) or dark urine, drink alcohol or drink alcohol. Due to the risk of liver damage when taking the drug, it is necessary to monitor liver function before and during the use of the drug, even if you do not have any abnormal signs, it should be checked periodically. Older women may be at greater risk of liver problems while using this medicine. This medication should not be substituted with other basic asthma medications. Patients can reduce the dose but need to be under the supervision of a doctor. This medicine cannot be used to treat acute asthma attacks, you still need to take your prescribed reliever medications for prevention. If you're on medication and your symptoms get worse or you need to take your asthma relievers regularly, you'll need to see your doctor again to have your medication adjusted. Psychiatric events have been reported in adult and adolescent patients receiving zileuton. Reports of zileuton use include: sleep disturbances and behavioral changes. This abnormality should be considered early and cautiously in individuals with a history of neuropsychiatric disorders. During pregnancy, this medicine should be used only when clearly needed. Discuss with your doctor the risks and benefits. It is not known whether this medicine passes into breast milk. Therefore, consult your doctor before breastfeeding. Drug interactions: You need to tell your doctor that you are taking any prescription or non-prescription medications. If you are taking theophylline medicine for asthma prevention, the blood thinner warfarin, or the blood pressure medicine propranolol, your doctor may need to change the dosage of these medicines.
Hopefully, with the above information, you know what Zyflo is and how it is used. If you have any questions, contact your doctor for advice.
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