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Zorabkit is a set of products containing 3 drugs Rabeprazole Sodium, Ornidazole and Clarithromycin, which have the main treatment effect in peptic ulcer. Here is some information to help you better understand Metobra Zorabkit.
1. What is Zorabkit?
Zorabkit is a medicine for treating digestive diseases, each pack of Zorabkit circulating on the market contains 6 pills made in the form of film-coated tablets, including:
2 Rabeprazole Sodium 20mg tablets; 2 Ornidazole 500mg tablets; 2 tablets of Clarithromycin 500mg.
2. Pharmacodynamics of ingredients of Zorabkit
2.1. Rabeprazole pharmacokinetics Rabeprazole sodium's mechanism of action is through inhibition of H+ (proton pump), K+ - ATPase.
Animal experiments have shown that rabeprazole inhibits gastric acid secretion in rabbits stimulated by dibutyl cyclic AMP present in the gastric gland. The mechanism of Rabeprazole sodium in inhibiting gastric acid secretion has also been demonstrated in dogs with chronic gastric fistula through the stimulation of histamine or pentagastrin. In rats, the inhibition of gastric acid secretion by Rabeprazole was also stimulated by histamine, in addition, Rabeprazole also demonstrated a strong anti-ulcer effect on the gastric ulcer lesions of rats in vitro. Rabeprazole sodium is indicated for the treatment of duodenal ulcer, Zollinger-Ellison syndrome, or gastroesophageal reflux disease.
2.2. Pharmacokinetics of Ornidazole Ornidazole is an imidazole derivative (similar to metronidazole), an antibiotic of the 5-nitroimidazole group. Ornidazole is active against obligate anaerobes (Bacteroides, Clostridium, Fusobacterium,...) and protozoa.
Ornidazole is converted to a reduction product and works by breaking the helix structure of the DNA strand, inhibiting DNA synthesis in the cell after entering the bacterial cell. Ornidazole is indicated for the prevention and treatment of biliary tract infections, gastrointestinal infections, treatment of abscesses or other anaerobic infections such as gas gangrene, necrotizing fasciitis.
2.3. Pharmacokinetics of Clarithromycin Clarithromycin is an antibiotic of the macrolide family. In-vitro, Clarithromycin has a broad spectrum of activity against many strains of aerobic or anaerobic bacteria, gram-positive or gram-negative bacteria, especially Clarithromycin is active against most Mycobacterium avium complex (MAC) bacteria.
Besides, 14-OH clarithromycin - a metabolite of clarithromycin, also actively participates in clinical antibacterial activity. 14-OH clarithromycin has been shown to be 2 times more effective against Haemophilus influenzae than clarithromycin.
However, cross-resistance of clarithromycin has been reported in previously methicillin- and oxacillin-resistant Staphylococcus strains.
3. Uses of Zorabkit
Zorabkit is indicated for the treatment of the following cases:
Stomach ulcers; Duodenal ulcer; Oral ulcer; Reflux esophagitis; Zollinger-Ellison syndrome.
4. Dosage and how to use Zorabkit
Zorabkit is a combination product of 3 different drugs, including a proton pump inhibitor (Rabeprazole Sodium) and two antibiotics (Ornidazole and Clarithromycin). Use Zorabkit only when prescribed by a doctor, that's why Zorabkit is marketed as a prescription drug.5. Side effects of Zorabkit
Undesirable effects when taking Zorabkit can come from drugs in the drug product range: Rabeprazole, Ornidazole and Clarithromycin.
When taking Rabeprazole, patients may experience the following symptoms:
Body as a whole: Asthenia, fever, chills, fatigue, allergic reactions, photosensitivity. Digestive: Dry mouth, loss of appetite, belching, digestive disorders, black stools, mouth ulcers, esophagitis, colitis, cholecystitis, pancreatitis,... Side effects when Zorabkit intake can come from Ornidazole, with the following manifestations:
Body as a whole: Somnolence, confusion, fatigue, allergic reactions. Neurological: Dizziness, headache, tremor, spasticity, convulsions, poor coordination, temporary loss of consciousness, signs of peripheral neuropathy. Gastrointestinal: Taste disturbance, vomiting, nausea. Clarithromycin can also cause some mild and transient side effects when using Zorabkit such as:
Gastrointestinal: Nausea, abdominal pain, taste disturbance, diarrhea, dyspepsia. Nervous: Headache.
6. Contraindications Zorabkit
Do not use Zorabkit in patients with hypersensitivity to the components of the drug. Zorabkit is also contraindicated in patients with other contraindications to Rabeprazole Sodium, Ornidazole and Clarithromycin.
People with hypersensitivity to Rabeprazole or benzimidazole derivatives are contraindicated for Zorabkit. Contraindicated to use Zorabkit in people with hypersensitivity to Ornidazole or imidazole derivatives. Patients with hypersensitivity to clarithromycin or any of the macrolide antibiotics are contraindicated to use Zorabkit. Patients using Terfenadin are also contraindicated to use Zorabkit with Zorabkit because Zorabkit contains clarithromycin, especially in patients with cardiovascular disease such as: arrhythmia, bradycardia, prolongation of the QT interval on electrocardiogram, disease myocardial ischemia, or electrolyte imbalance.
7. Precautions when using Zorabkit
Before starting treatment of peptic ulcer with Zorabkit, it is necessary to exclude malignancy in the stomach and duodenum for timely treatment. Zorabkit should be used with caution in patients with hepatic impairment. Note on pregnant and lactating women: Do not use the drug in pregnant or lactating women, unless absolutely necessary and prescribed by a doctor. Ornidazole can cause confusion, somnolence, dizziness, fatigue, so it is not recommended to drive or operate machinery when these symptoms appear after taking the drug. In this case, treatment with Ornidazole should also be discontinued. The basic information about Zorabkit in the article is for reference only. Because this is a prescription drug, patients should not use it on their own, but need to contact a specialist directly to get an appropriate prescription to ensure safety for health.
