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Zicoraxil contains the main ingredient Cefadroxil, which is commonly recommended for the treatment of bacterial infections in both children and adults. To ensure effective treatment of the disease, the patient should follow the instructions given by the doctor. Read the article below to get more useful information about the use of this drug.
1. The effect of the drug Zicoraxil
The Cefadroxil component in Zicoraxil has a medium spectrum of activity, acting on gram-positive bacteria such as staphylococcus, streptococcus, pneumococcus (except methicillin-resistant streptococcus).Cefadroxil also has a positive treatment effect on infections with gram-negative bacteria such as E.coli, Klebsiella pneumoniae, Proteus mirabilis and Shigella.
Cefadroxil works by inhibiting bacterial cell wall synthesis, bactericidal inhibits the final stage of bacterial cell wall synthesis, causing bacteria without a wall to be destroyed.
Thanks to the above effects of Cefadroxil, Zicoraxil is indicated in the following cases:
Urinary tract infections. Skin & skin structure infections. Pharyngitis, tonsillitis. Respiratory tract infections. On the other hand, in case the patient is hypersensitive to the cephalosporin component, it is contraindicated to prescribe.
2. Dosage and usage of Zicoraxil
Zicoraxil is in the form of capsules, so it is recommended to take it orally. Patients should adhere to the instructions to take medicine from the doctor such as: take the whole pill, do not crush, break it... to avoid affecting the pharmaceutical properties of the drug.
The time to take the drug can be from 1-2 times / day, depending on the patient's condition.
Adult dosage 1 - 2 g/day. Dosage for children: 25 - 50 mg/kg/day. Patients with renal impairment are adjusted according to the creatinine clearance (ClCr), specifically: ClCr 25 - 30 mL/min: dose at 12 hour intervals. ClCr 10 - 25 mL/min: dose every 24 hours. ClCr 0 - 10 mL/min: dose every 36 hours. Using a missing dose of Zicoraxil significantly affects the activity of the drug. This condition can cause the drug to decrease the mechanism of action, leading to not completely treating the disease symptoms;
If the patient forgets to take a dose of Zicoraxil, take it as soon as you remember. In case it is almost time for the next dose, skip the missed dose and take the next dose as scheduled;
Using Zicoraxil overdose can cause dangerous symptoms such as nausea, vomiting, epigastric pain and diarrhea. Patients should proactively notify their doctor if they find themselves using more than the recommended dose. At that time, the doctor will prescribe measures to keep the airway open, do blood gas tests and serum electrolytes.
Anticonvulsants may be prescribed if the patient develops symptoms of an overdose due to taking a larger dose than prescribed.
3. Zicoraxil side effects
Cefadroxil ingredients in the drug are suitable for many subjects. However, during treatment, the drug can cause some side effects. Note that the patient has symptoms of nausea, vomiting, diarrhea, urticaria, rash..
Other side effects include genital itching, vaginitis, transient neutropenia..
According to experts, these are considered mild side effects that can go away on their own after stopping the drug.
4. Zicoraxil drug interactions
Like many other drugs, Zicoraxil has the potential to interact when combined with one or more other drugs. The consequences of this process will make the drug increase or decrease the therapeutic effect, or give rise to some unwanted effects that are detrimental to the patient. Some drugs that may interact with Zicoraxil include:
Probenecid reduces renal tubular secretion of Cefadroxil, increases and prolongs the elimination half-life, and increases the risk of toxicity. False-positive Coombs reactions are common in many patients, and false-positive urinary glucose can occur with the Benedict test and Fehling's solution. In addition, alcohol and certain foods can react with Zicoraxil.
5. Precautions when using Zicoraxil
Using safe drugs not only shortens the treatment time but also saves costs for the patient. Therefore, patients need to "take to heart" the following notes after treatment with Zicoraxil:
Before prescribing the drug, the patient should be informed about the history of hypersensitivity to penicillin in order to limit cross-allergies. Patients with renal impairment with creatinine clearance < 50 ml/min/1.73 m2 should be used with caution. Patients with diseases of the gastrointestinal tract, especially colitis or peptic ulcer disease, only use the drug with the consent of the doctor. The drug can be secreted into breast milk, so women who are breast-feeding should consult their doctor if they should be treated with Zicoraxil. Carefully read the instructions for storage of the drug on the box and read the instruction sheet for Zicoraxil. Store the medicine in a cool, dry place, avoid direct sunlight or high temperature, it can convert the ingredients in the medicine. Zicoraxil, which contains the active ingredient Cefadroxil, is commonly recommended for the treatment of bacterial infections in both children and adults. To ensure effective treatment of the disease, the patient should follow the instructions given by the doctor.
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