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Xalexa 30mg is used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual affective disorder.1. What is Xalexa 30mg?
Xalexa drug has the main active ingredient is Paroxetin, the drug is prepared in the form of film-coated tablets with a content of 30mg. Paroxetin - a derivative of phenylpiperidin is an antidepressant belonging to the group of drugs that selectively inhibit serotonin reuptake at the anterior synapse of serotoninergic neurons, leading to an increase in the concentration of serotonin reaching the posterior synapse, improving symptoms of depression in depressed patients.
Paroxetine is used to treat depression, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorders, and premenstrual disorders.
At therapeutic doses, Paroxetin only has a selective inhibitory effect on the serotonin reuptake channel but has little effect on other receptors such as anticholinergic, α1-adrenergic blocker or antihistamine; Paroxetin has no adverse effects on psychomotor function and does not have much effect on heart rate, blood pressure, diabetes. Therefore, the risk of adverse effects due to anticholinergics (dry mouth, blurred vision, urinary retention, constipation), antihistamines (sedation) or α1-adrenergic blockers (orthostatic hypotension) is less likely to occur with the use of this medication. treated with paroxetine.
2. Indications and contraindications to the use of Xalexa
2.1 Indications Xalexa is indicated in the following cases:
Depression. Obsessive Compulsive Disorder (OCD) Panic disorder. Social phobia (social anxiety disorder). Anxiety disorders. Post-traumatic stress disorder. Emotional disturbance before menstruation. 2.2 Contraindications Xalexa is contraindicated in the following cases:
Allergy or hypersensitivity to Paroxetin or any of its ingredients. Are taking MAO inhibitors (take them at least 2 weeks apart). Not to be used concurrently with Pimozide, Thioridazine, Linezolid.
3. How to take Xalexa 30mg
Xalexa 30mg is taken orally. Xalexa must be swallowed whole, not chewed. Food does not affect the absorption of the drug, so to limit the side effects of the drug should be taken with food. Take Xalexa once a day in the morning.
3.1 Dosage Types of depression, major depression, reactive depression and anxiety depression
Dose 20mg/day, taken once in the morning. The maintenance dose is varied according to the clinical response of the individual patient. Then gradually increase by 10mg weekly to 50mg/day. Usually after a few weeks, the therapeutic effect is achieved, so the dose of Xalexa should not be increased beyond the prescribed dose.
Obsessive-compulsive disorder
Recommended dose 40mg/day. Initial dose is 20 mg/day, gradually increased by 10 mg weekly to a maximum dose of 60 mg/day.
Panic disorder
Recommended dose 40mg/day. Initial dose is 20 mg/day, gradually increased by 10 mg weekly to a maximum dose of 50 mg/day.
Post-traumatic stress disorder
The recommended dose is 20mg/day, increased in increments of 10mg weekly to a maximum dose of 40mg/day. But 40mg/day is unlikely to be more beneficial than 20mg/day.
Premenstrual dysphoric disorder
Paroxetine approved only as Brisdelle (R): treatment of moderate to severe vasomotor symptoms associated with menopause: 7.5mg/day orally once before departure sleep.
Elderly: Initial dose of 20mg/day, gradually increased by 10mg weekly to a maximum dose of 40mg/day. Children < 18 years old: Currently, the safety and effectiveness of using this drug have not been determined. Patients with renal impairment: No dose adjustment of Xalexa is required. Patients with hepatic impairment: No dose adjustment is required in patients with mild hepatic impairment. 3.2 Overdose and management Symptoms may occur when taking an overdose of Xalexa: nausea, vomiting, dizziness, sweating. Symptoms such as agitation, hypomania, and signs of CNS excitation may occur.
Treatment of Xalexa overdose is mainly symptomatic and supportive. Reduce drug absorption by giving activated charcoal or sorbitol. In addition, maintain respiration, cardiac activity and body temperature for the patient. In some cases, anticonvulsants such as diazepam may be used.
4. Undesirable effects when taking Xalexa 30mg
When starting the drug, restlessness, anxiety or trouble sleeping may occur in about 10-20% of cases. Nausea may also occur at a rate of 10% and is dose dependent.
Whole body: fatigue, weakness, dizziness, sweating, yawning, weight gain. Psychiatric and central nervous system: tremor, headache, impaired concentration, impaired sexual function. Restlessness, agitation, anxiety, insomnia, nightmares. Extrapyramidal reaction. Gastrointestinal: anorexia, dry mouth, nausea, diarrhea, constipation. Skin: : skin rash, itching. Some other side effects: increased cholesterol levels, hepatitis, cholestatic jaundice, hyponatremia. Discontinue Xalexa if you develop a skin rash or hives. Go to a medical facility for timely treatment when experiencing unwanted effects while taking Xalexa.
5. Some notes when taking Xalexa
Avoid concomitant use with monoamine oxidase (MAO) inhibitors, as may cause serotonin syndrome. Initiate MAO inhibitors when paroxetine has been completely eliminated (at least 2 weeks). Patients with cardiovascular disease, liver disease or reduced liver function: reduce the dose of the drug and use it with caution. Use caution when using the drug in epileptic patients with a history of convulsions. Discontinue Xalexa when seizures occur. Patients treated with antidepressants for any indication should be closely monitored for depression, suicidal ideation, and behavioral abnormalities, particularly during the initial phase of treatment. and during the dose adjustment phase. If any changes in behavior such as irritability, agitation, or suicidal thoughts appear, notify the treating physician. If stopping the drug, it must be stopped gradually, avoiding abrupt discontinuation of the drug. Pregnancy: Some studies have shown that the use of paroxetin in doses above 25 mg/day in pregnant women during the first 3 months of pregnancy may increase the risk of birth defects in the fetus. Using the drug in the last 3 months of pregnancy, the newborn may show symptoms such as respiratory failure, apnea, cyanosis, convulsions, hypoglycemia, sleep disturbance. Paroxetine should not be used by pregnant women. The drug should only be used when there is no alternative medicine and the benefits and risks need to be weighed when using the drug. Lactation: Paroxetin is likely to be excreted in breast milk, so the drug may affect a nursing infant. Paroxetine should not be used by women who are breastfeeding. If Xalexa is used, breast-feeding should be discontinued during treatment. Ability to drive and use machines: Xalexa may cause drowsiness, impaired judgment and judgment. Care should be taken when using Xalexa when driving or operating machinery.
6. Drug interactions
MAO inhibitors: do not use concomitantly with Xalexa. Take these two medications at least 2 weeks apart. Patients should tell their doctor about all medicines you are taking, especially the following:
Atomoxetine, Procyclidin, Tamoxifen, Cimetidine, Metoprolol. Tryptophan. Warfarin, Coumadin, Jantoven. Medicines to treat arrhythmias. Medicines to treat HIV/AIDS. Narcotic analgesics: Tramadol, Fentanyl. Medicines for mood disorders, thought disorders or mental illness, other antidepressants, antipsychotics. Carbamazepine, Phenytoin. Xalexa 30mg is used to treat depression, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual affective disorder. To ensure the effectiveness of treatment and avoid side effects, users need to strictly follow the instructions of the doctor, professional pharmacist.
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