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B vitamins play an important role in the body, especially Vitamin B1 or Thiamin. Cases of deficiency of this vitamin need to be supplemented with preparations such as Vitamin B1 250mg.
1. What are the effects of Vitamin B1 250Mg?
Vitamin B1 250mg is a product of Mekophar Chemical - Pharmaceutical Joint Stock Company with the main ingredient being vitamin B1 (Thiamin). Vitamin B1 250mg is used to treat severe vitamin B1 deficiency, a metabolic disorder caused by an inherited enzyme deficiency that is responsive to thiamin. Vitamin B1 250mg is in the form of sugar coated tablets with a content of 250mg Thiamine.
Thiamin (vitamin B1) is a water-soluble vitamin, belonging to vitamin B group. Thiamin combines with Adenosine triphosphate in liver, kidney and white blood cells to form Thiamin diphosphate (thiamine pyrophosphate) with physiological activity. Thiamine diphosphate is a carbohydrate metabolism coenzyme, responsible for decarboxylation of alpha-cetoacids such as pyruvate and alpha-ketoglutarate.
The amount of vitamin B1 the body needs daily is from 0.9 - 1.5mg for men and 0.8 - 1.1mg for healthy women. Vitamin B1 requirements are directly related to carbohydrate intake and metabolic rate, when vitamin B deficiency, the oxidation of alpha-cetoacids will be affected, causing the concentration of pyruvate in the blood to increase and continue to change. into lactic acid, thereby helping to diagnose thiamin deficiency.
The absorption of vitamin B1 in the daily diet through the gastrointestinal tract is due to active Na+ independent transport. In adults, about 1mg of vitamin B1 is completely metabolized per day in tissues and this is the minimum amount the body needs daily.
When absorption is low, little or no vitamin B1 is excreted in the urine. When absorption of vitamin B1 exceeds the minimum requirement, after saturation in tissues, excess vitamin B1 will be excreted in the urine as intact vitamin B1 molecule. As vitamin B1 absorption is further increased, excretion as unmetabolized vitamin B1 is increased.
2. Dosage of Vitamin B1 250Mg
Vitamin B1 medicine 250mg manufactured for oral use with a specific dose prescribed by a doctor. The usual recommended dose for adults is 250mg/day (equivalent to 1 250mg vitamin B1 tablet).
Patients should note that the recommended dose above is for reference only. The specific dose of Vitamin B1 250mg drug depends on the condition and progress of each patient. To get the right dose, the patient should consult a doctor or healthcare professional.
So far there have been no reports of overdose of Vitamin B1 250mg. If an overdose occurs, the patient is primarily treated symptomatically.
If a dose of Vitamin B1 250mg is missed, the patient should take it again as soon as possible. However, if it is almost time for your next dose, skip it and take your next dose at the usual schedule. An important note is that patients should not double the prescribed dose of Vitamin B1 250mg.
3. Side effects of Vitamin B1 250mg
When using Vitamin B1 250mg, patients are still at risk of some unwanted effects (ADRs). However, the incidence is relatively rare (ADR < 1/1000):
Profuse sweating; Vitamin B1 medicine 250mg can cause acute hypertension; Skin rash, itching, hives; More serious medicine Vitamin B1 250mg can cause breathing difficulties. If you encounter any unwanted effects during the course of taking Vitamin B1 250mg, the patient should immediately notify the doctor or pharmacist for appropriate treatment.
4.Some notes when using Vitamin B1 250mg
Before using the drug Vitamin B1 250mg, patients need to read and learn carefully the accompanying instructions for use and consult a doctor.
Vitamin B1 250mg is contraindicated for use in the following cases:
Hypersensitivity to any ingredient in Vitamin B1 250mg medicine. Some issues need to be cautious when using Vitamin B1 250mg:
Vitamin B1 250mg product contains lactose and white sugar. Therefore, caution should be exercised when administering to patients with rare hereditary problems of galactose and fructose intolerance, the Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency; Vitamin B1 250mg preparations include parabens, which are preservatives that can cause allergic reactions, so it should be used with caution; Vitamin B1 250mg preparations contain castor oil, so there is a risk of stomach upset and diarrhea. Ability to drive and use machines: There have been no reports of adverse reactions of Vitamin B1 250mg on the ability to drive vehicles and use machines, people working at height and other cases.
Use of Vitamin B1 250mg during pregnancy: The need for Vitamin B1 for pregnant women is 1.5mg/day. This subject only needs to supplement with vitamin B1 if the diet does not provide enough of this vitamin. Therefore, Vitamin B1 250mg pills are not suitable for women during pregnancy because of the high vitamin B1 content.
Use of Vitamin B1 250mg during lactation: The diet for lactating women needs about 1.6mg of vitamin B1 per day and only needs to be supplemented when the diet does not provide enough. Therefore, Vitamin B1 250mg is not suitable for this audience.
5. Drug interactions of Vitamin B1 250mg
Vitamin B1 250mg may increase the effect of neuromuscular blocking agents.
Thiamine antagonists, thiosemicarbazone and 5-fluorouracil can neutralize the effectiveness of Vitamin B1 250mg. Therefore, patients taking any of the above medications may need to have their Vitamin B1 250mg dose adjusted accordingly.
Thiamine may cause a false-positive test for urobilinogen by the Ehrlich reaction. At the same time, high doses of Vitamin B1 250mg may interfere with spectroscopic tests that measure plasma theophylline concentrations.
Due to the lack of incompatibility studies, vitamin B1 250mg should not be mixed with other drugs.
Above is information about the drug Vitamin B1 250mg, patients need to carefully read the instructions for use, consult a doctor before use. When the drug is no longer in use, you need to collect and dispose of it according to the manufacturer's instructions.
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