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Vesicare 5mg medicine is made in the form of tablets, with the main ingredient being Solifenacin 5mg. Drugs are often used in the treatment of certain diseases related to the urinary tract. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
1. Uses of Vesicare 5mg
Is Vesicare 5mg good? The active ingredient is Solifenacin 5mg. It is a specific and competitive cholinergic receptor antagonist. Vesicare 5mg is indicated for use in the following cases:
Treatment of urinary incontinence symptoms due to urge (urinary incontinence); Symptomatic treatment of urinary frequency and urgency (may occur in patients with overactive bladder syndrome). Contraindications to the use of Vesicare 5mg:
Patients with urinary retention, severe gastrointestinal conditions (including toxic megacolon), severe myasthenia gravis, narrow-angle glaucoma or people at risk for the above problems ; Patients with hypersensitivity to active ingredients and ingredients of the drug; The patient is on hemodialysis; Patients with severe liver failure; Patients with severe renal impairment or moderate hepatic impairment, being treated with a strong CYP3A4 inhibitor such as ketoconazole.
2. How to use and dose Vesicare 5mg
Usage: Orally. The patient should swallow the tablet whole with water, with or without food.
Dosage:
Adults (including the elderly): The recommended dose is 5mg/time/day/ If necessary, up to 10mg/time/day can be used; Children and adolescents: The safety of Vesicare 5mg has not been determined in this group of people, so it should not be used for children; Patients with renal impairment: No dosage adjustment is required for patients with mild to moderate renal impairment (creatinine clearance above 30ml/min). Patients with severe renal impairment (creatinine clearance less than 30ml/min) should be treated with caution, not more than 5mg/time/day; Patients with hepatic impairment: No dosage adjustment is required for patients with mild hepatic impairment. For patients with moderate hepatic impairment, it should be treated with caution, not more than 5mg/time/day; For users of strong cytochrome P450 3A4 inhibitors: The maximum dose of Vesicare is 5mg when co-administered with ketoconazole or other strong inhibitors of CYP3A4 such as ritonavir, nelfinavir, itraconazole. Overdose: When Vesicare overdoses, patients may experience serious anticholinergic effects. In case of drug overdose, the patient should be treated with activated charcoal. If resuscitation is performed within 1 hour, gastric lavage may be indicated (should not induce vomiting).
Missed dose: If the patient forgets a dose of Vesicare 5mg, the medicine should be taken as soon as possible. If it is almost time for your next dose, skip the missed dose and take your next dose as originally scheduled.
3. Side effects of Vesicare 5mg
When using Vesicare 5mg, patients may experience some side effects such as:
Common: Blurred vision, nausea, indigestion, abdominal pain, constipation; Uncommon: Dry eyes, gastroesophageal reflux disease, dry throat, cystitis, urinary tract infection, somnolence, dysgeusia, dry nose, dry skin, dysuria, fatigue, peripheral edema, ... When experiencing side effects of Vesicare 5mg, the patient should stop using, notify the doctor or go to the nearest hospital for timely treatment.
4. Be careful when using Vesicare 5mg
Some notes patients need to remember before and while using Vesicare 5mg:
Use Vesicare according to doctor's prescription; Other causes of urinary frequency (kidney disease or heart failure) should be evaluated prior to treatment with Vesicare; If a urinary tract infection is present, the patient should receive appropriate antibacterial therapy; Vesicare 5mg should be used with caution in patients with: Obstruction of urine drainage from the bladder with risk of urinary retention, gastrointestinal obstruction, risk of decreased bowel motility, severe renal impairment, moderate hepatic impairment, concomitantly with a CYP3A4 inhibitor, hiatal hernia/gastroesophageal reflux/esophagitis, concomitant use of drugs that can cause esophagitis, autonomic neuropathy; In patients with pre-existing risk factors (pre-existing long QT interval, hypokalemia), the use of Vesicare may prolong the QT interval and torsades de pointes; Older adults may be more sensitive to the side effects of Vesicare 5mg, especially drowsiness, constipation, confusion, etc. Drowsiness and confusion may increase the risk of falls. fall; The safety and effectiveness of the drug has not been established in patients with neurogenic hyperactivity of bladder muscles; Do not use the drug in patients with galactose intolerance, glucose-galactose malabsorption or Lapp lactase deficiency; Some patients taking solifenacin succinate (the main active ingredient of Vesicare) may experience angioedema or airway obstruction. If angioedema occurs, the patient should discontinue the drug and institute appropriate treatment; Some patients when taking Vesicare have experienced anaphylactic reactions. If this occurs, the drug should be discontinued and appropriate treatment instituted; The maximum effect of Vesicare 5mg can be determined as early as 4 weeks; Vesicare can cause blurred vision, drowsiness and fatigue, so caution should be exercised when using the drug in drivers, operating brain machines or doing things that require concentration and alertness; Vesicare 5mg medicine can cause decreased sweating, difficult to escape heat, increasing the risk of heat stroke. Therefore, drug users should limit their activities in places with too high temperature, to avoid dehydration, especially when exercising in hot weather; With caution when using Vesicare in pregnant and lactating women, consult your doctor before taking it.
5. Vesicare 5mg . drug interactions
Vesicare may change the effectiveness of medications you are taking or increase side effects. To avoid the risk of drug interactions, you should list the health protection drugs/foods you are taking to your doctor. At the same time, you should also pay attention not to self-medicate, stop or change the dose of the drug without the permission of your doctor.
Some drug interactions Vesicare 5mg include:
Concurrent use of Vesicare with other drugs with anticholinergic properties may increase treatment effects and side effects. Therefore, Vesicare should be discontinued approximately 1 week before starting another anticholinergic drug; The therapeutic effect of solifenacin may be reduced if co-administered with cholinergic receptor agonists; Solifenacin may reduce the effect of drugs that stimulate gastrointestinal motility such as metoclopramide and cisapride; At therapeutic concentrations, solifenacin did not inhibit CYP1A1/2, 2C9, 2C19, 2D6 or 3A4 derived from human liver microsomes. Therefore, solifenacin is unlikely to alter the clearance of drugs metabolised by these CYP enzymes; Component Solifenacin is metabolised by CYP3A4. Co-administration of Vesicare with ketoconazole (200 mg/day), which is a strong inhibitor of CYP3A4, resulted in a 2-fold increase in the area under the curve (AUC) of solifenacin. Taking ketoconazole at a dose of 400 mg/day resulted in a 3-fold increase in the UAC of solifenacin. Therefore, the maximum dose of Vesicare used is 5mg when used in combination with ketoconazole or other strong inhibitors of CYP3A4 (eg ritonavir, nelfinavir, itraconazole); Do not use solifenacin with a strong inhibitor of CYP3A4 in patients with moderate hepatic impairment or severe renal impairment; Because solifenacin is metabolised by CYP3A4, interactions with other CYP3A4 mechanisms of higher affinity such as verapamil, diltiazem and inducers of CYP3A4 such as phenytoin, rifampicin, and carbamazepine may occur. When using Vesicare 5mg, the patient should absolutely follow all the instructions of the doctor about the dose, how to use the drug. If you experience any unusual symptoms, you should consult your doctor for timely support. In short, Vesicare 5mg is made in the form of tablets, with the main ingredient being Solifenacin 5mg. Drugs are often used in the treatment of certain diseases related to the urinary tract. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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