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Vasblock 80mg drug is a drug belonging to the group of strong Angiotensin II receptor antagonists, drugs used in the treatment of hypertension, heart failure... To use the drug safely and effectively, you need to understand the work. use and caution when taking the drug.
1. Uses of Vasblock 80mg
Vasblock 80mg has the main active ingredient Valsartan with a strength of 80mg. The drug is available in the form of film-coated tablets. Valsartan is a synthetic agent that belongs to the class of drugs that selectively block the AT1 receptor of angiotensin II. Angiotensin II is a potent vasoconstrictor and a determinant of the pathophysiology of hypertension. When the body makes Angiotensin II, it needs to bind to a receptor called AT1 (this receptor is present in many different tissues such as vascular smooth muscle, adrenal glands, kidneys, and heart) and make proteins. Biological effects such as vasoconstriction and aldosterone release cause an increase in blood pressure.
Valsartan is a selective blocker of the AT1 receptor, it competes for binding to this receptor in organs, so Angiotensin II cannot bind to the receptor, so it does not cause blood pressure-raising effects.
2. Indications and contraindications of the drug Vasblock 80mg
Indication of Vasblock 80mg drug in the following cases:
Primary or secondary hypertension. Treatment after myocardial infarction: To improve the post-myocardial infarction status in clinically stable patients, but with signs and symptoms of heart failure or left ventricular systolic dysfunction. Heart Failure: Treatment of symptomatic heart failure in adults in patients unable to take ACE inhibitors or as adjunctive therapy to angiotensin-converting enzyme inhibitors when the patient is unable to take them. beta-blockers. Contraindications: Do not use the drug in the following cases
Hypersensitivity to Valsartan or any other excipients of the drug. Severe liver failure, patients with biliary cirrhosis and cholestasis. Contraindicated for pregnant women in the second and third trimesters. In the first 3 months of pregnancy, it is not recommended to use, if used, it is necessary to carefully weigh the benefits and risks to the fetus. Functional aortic stenosis. Renal artery stenosis and damage causing narrowing of the renal artery.
3. Usage and dosage of Vasblock 80mg
How to use the drug: The drug is prepared in the form of tablets, to be taken orally.
Specific dosage is as follows:
For adults:
Hypertension: The recommended starting dose is 80mg once a day. For patients whose blood pressure is not well controlled, the daily dose can be increased to 160 mg and to a maximum of 320 mg. Or it can be taken with medications to treat high blood pressure such as diuretics and calcium channel blockers. Treatment after myocardial infarction: Patients are clinically stable, can be started as early as 12 hours after myocardial infarction. The initial dose was 20 mg, twice daily, then titrated up over the following weeks to reach the target dose and to a maximum of 160 mg twice daily. Heart failure: The recommended starting dose is 40 mg twice daily. Dosage can be up to 80 mg or 160 mg, twice daily for 2 weeks. The maximum daily dose administered in the trials was 320 mg in divided doses. Elderly, renal failure with creatinine clearance >10 ml/min do not need to adjust the dose. Mild to moderate hepatic impairment should not exceed 80mg. For children:
Hypertension : Children 6 years and older. The recommended dose is 40mg for children under 35kg and no more than 80mg per day. Dose 80mg per day for children over 35kg, not more than 160mg for children from 35 to 80kg. Children 6 years of age and older with renal impairment if the creatinine clearance is < 30 ml/min, the use of valsartan is not recommended. If creatinine clearance >30ml/min, no dose adjustment is required. For children under 6 years of age, there are no safety studies.
4. Side effects when using Vasblock 80mg
When taking the drug you may experience some of the following side effects:
Headache, dizziness. Upper respiratory tract infections, diarrhea, fatigue, rhinitis, sinusitis, back pain, abdominal pain, nausea, joint pain, arthritis. Edema, fatigue, insomnia, rash, physiological weakness, dizziness. Orthostatic hypotension, hyperkalemia, thrombocytopenia, increased liver enzymes. You may experience other effects, so if you feel unusual while taking the medicine, you need to inform your doctor or see a doctor promptly.
5. Note when using Vasblock 80mg
Inform your doctor about allergies and other medical conditions before taking the medicine. Follow the correct dose of the doctor, avoid changing the dose on your own. In patients with severe sodium or fluid loss such as those treated with high-dose diuretics, symptomatic hypotension has rarely occurred after initiation of valsartan therapy, but should be treated prior to initiation of therapy with valsartan. medication, eg reducing the dose of diuretics. Patients with mild to moderate renal artery stenosis produced almost no significant changes in renal hemodynamics. However, because drugs that affect the renin-angiotensin-aldosterone system may increase blood urea and serum creatinine in patients with renal artery stenosis. Therefore, it is recommended that monitoring of both parameters in this patient is a safety measure. Lactation: It is not known whether valsartan is excreted in human milk. Therefore, the use of valsartan in nursing mothers is not recommended. Interactions between Vasblock 80mg and other drugs may occur. Some drugs should not be combined with:
Lithium: Increased serum lithium concentrations have been reported with concomitant use of lithium with ACE inhibitors causing toxicity. Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium, and others can lead to hyperkalemia. Because the combination increases the risk of dangerous hyperkalemia. Caution should be exercised when co-administering with non-steroidal anti-inflammatory drugs, as they may reduce the effectiveness of antihypertensive agents. In addition, it may adversely affect renal function and increase serum potassium levels. If co-administration is required, renal function should be monitored and the patient should be adequately hydrated during treatment. Overdose with valsartan can cause hypotension, leading to decreased consciousness, circulatory collapse, shock. If hypotension occurs, the patient should be placed in the supine position and volume correction considered. Store the medicine in a dry place, away from direct light, out of reach of children.
Hopefully, through this article you have had a basic understanding of Vasblock 80mg drug. Accordingly, this drug is only used with a doctor's prescription. Therefore, you need to use under the guidance and consult your doctor when any abnormalities occur.
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