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Ursobil-300 is a prescription medicine that contains ursodeoxycholic acid as the main ingredient. Ursobil 300 belongs to the list of drugs that protect the liver, bile, dissolve stones and are often clinically indicated by doctors for cases where liver function enhancement, anorexia, dyspepsia, ...1. What is Ursobil 300mg?
Ursobil-300 medicine has the active ingredient Ursodeoxycholic Acid as the main active ingredient.
Dosage form: tablets Packing form: blisters of 10 tablets, each box has 3 blisters. Ingredients in each tablet: 300mg ursodeoxycholic acid and excipients just enough. Ursodeoxycholic acid is a hydrophilic bile acid. Oral administration of Ursobil 300 increases the ratio of this acid in bile and adjusts the dosage to become the body's main bile acid, or can replace toxic endogenous hydrophilic bile acids in cholestatic liver disease. Ursodeoxycholic acid also has the effect of protecting bile duct epithelial cells, inhibiting the self-destruction of liver cells, ... In addition, ursodeoxycholic acid can be used to treat cholesterol gallstones.
Ursodeoxycholic acid is absorbed from the gastrointestinal tract by passive diffusion. The extent of hepatic absorption is reduced in the presence of liver disease. Distribution: Upon entering the liver, Ursobil combines with glycine or taurine and then into the bile. Enteric enzymes in the ileum can break down this conjugate and form free ursodeoxycholic acid that can be recombined or reabsorbed in the liver. Metabolism: Unabsorbed Ursobil is dehydroxylated to lithocholic acid in the colon. Part of the ursodeoxycholic acid is converted to chenodiol, and then to lithocholic acid. Elimination: Ursobl is excreted in the bile as a glycoconjugate or sulfate moiety and in the feces.
2. The effect of the drug Ursobil-300
Ursobil 300 is indicated in the following cases:
Improve liver function in patients with primary biliary cirrhosis Protect liver cells when drinking Alcohol Support patients with anorexia, dyspepsia due to dysfunction Hepatobiliary stones Dissolve for: non-calcified gallstones, not visible on x-ray, less than 20mm in diameter, gallstones in patients unable to have cholecystectomy or at risk of complications during surgery. Contraindication of Ursobil-300:
Patients with hypersensitivity to any ingredient in Ursobil 300 Complete shutdown of the bile ducts Rapidly progressing hepatitis Inflammation of the gallbladder, acute bile ducts Decreased contractile function Gallbladder Having calcified stones on X-ray Women planning to become pregnant, pregnant women, lactating women Under 12 years old
3. Dosage and how to use Ursobil 300
Ursobil-300 is a prescription drug, so you should remember to follow your doctor's instructions on the dosage and route of administration for the drug to have a good effect and avoid adverse health effects.
Drug route: oral tablet Time to take: take after eating. Dosage: This medicine is for adults and children over 12 years old. For patients with primary biliary cirrhosis: 13-15mg/kg/day, divided into 2-4 doses. During the first 6 months of treatment, liver function tests and bilirubin levels should be checked monthly and then repeated every 6 months. Dissolution dose: 8-12 mg/kg/day, divided into 2-3 oral doses. Note that maximum use is 2 years, the last dose of the day is after dinner. Patients should have an ultrasound to check the effectiveness at 6 and 12 months, then follow up for 1-3 months. Continue using the drug for another 3-4 months after the stone has completely dissolved. If, after 1 year of examination, the stones are not reduced, the treatment method should be changed. What to do in case of overdose or missed dose?
In case of overdose: rarely any symptoms other than diarrhea occur. In this case, oral rehydration and electrolyte solutions can be given. If dangerous symptoms appear, immediately contact the emergency center for timely treatment. If you miss a dose: take another dose as soon as you remember, but if it's almost time for your next dose, take the next dose and skip the missed dose. Patients should not arbitrarily compensate by taking 2 doses at a time.
4. Ursobil-300 . side effects
During treatment with Ursobil-300, the following side effects may be encountered:
Diarrhea, pasty stools: common Change in time and duration of defecation: rare Upper abdominal pain, right side, urticaria, calcified gallstones, liver disorders: very rare Contact your treating physician immediately and report all medications you are taking, including oral, injectable, topical application, vitamins, herbs, .. for timely diagnosis and treatment.
5. Some notes when using Ursobil 300
Be careful when using Ursobil-300 and use it exactly as prescribed by your doctor. Must do laboratory tests to monitor liver function every 4 weeks for the first 3 months of treatment, then every 3 months.
When treating cholesterol stones: X-ray of the gallbladder with vertical and lying contrast after 6 - 10 months of treatment to evaluate the effectiveness of treatment as well as early detection of calcification of gallstones
For pregnant women: Currently, there are no complete data on the harmful effects of ursobil-300 on the fetus, so it is absolutely not used for this subject.
Women planning pregnancy: used when using safe, effective contraception.
Lactating women: There are no clear studies on whether Ursobil 300 is excreted in breast milk and affects nursing infants, so do not use it on this subject. In cases where medication is required, breastfeeding can be stopped.
The drug does not cause drowsiness, so it does not affect driving and operating machines.
In summary, Ursobil 300 is a highly effective drug in enhancing hepatobiliary function, lithotripsy, etc. However, like any other drug, it is necessary to read the drug information carefully and adhere to it strictly. Follow the doctor's instructions to maximize the effectiveness of the drug as well as limit the unfortunate risks to health.
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