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Urocoline is a psychotropic drug whose main ingredient is citicoline, which is often used in the acute phase of traumatic brain injury to improve symptoms and prevent dangerous complications. So how should Urocoline be used?1. How does Urocoline work?
Urocoline drug has the main ingredient citicoline which is a drug that stimulates the synthesis of phospholipids on nerve cell membranes. Citicoline reduces brain glutamate levels and increases adenosine triphosphate, thereby providing protection against ischemic neurotoxicity. Citicoline also helps increase glucose metabolism in the brain and cerebral blood flow as well as increase the neurotransmitters acetylcholine, norepinephrine and dopamine.
Citicoline stimulates the biosynthesis of structural phospholipids of neuronal membranes, improves the function of membrane mechanisms, such as the action of ion exchange pumps and post-introduced receptors, modulation essential in neurotransmission. Citicoline due to its membrane-stabilizing activity has properties that favor cerebral edema reabsorption. In addition, experimental studies have shown that citicoline inhibits the activation of several phospholipases (A1, A2, C and D), reduces the formation of free radicals, avoids damage to the membrane system, and preserves glutathione antioxidant defense system.
Clinical trials have shown that citicoline significantly increases the functional evolution of patients with acute ischemic stroke, coinciding with a lower development of ischemic injury brain in neurological tests. Thus in patients with traumatic brain injury, citicoline accelerates recovery and reduces the duration and intensity of the post-traumatic syndrome. Citicoline improves attention and consciousness and acts more favorably than amnesia and ischemic-associated neurological and cognitive disorders.
Urocoline drug is usually indicated in the following cases:
Treatment of acute phase of severe traumatic brain injury with disturbances of consciousness Used in the treatment of cerebrovascular accidents
2. Dosage of the drug Urocoline
Urocoline is prepared as a solution for IV injection in acute cases, IM injection in other cases. Dosage of Urocoline is as follows:
Acute phase: 500-750 mg/24 hours New sequelae: 250 mg/24 hours Daily recommended dose falls in the range of 500-2000 mg depending on the medical condition and patient response. The duration of treatment lasts 6 weeks for acute exacerbations and 12 months for chronic cases, depending on the severity of the disease. In case of ischemic stroke or traumatic brain injury, cerebral hemorrhage, use 2g a day, divided into 2 times, duration of treatment is 6 weeks. In case of neurological sequelae due to acute stroke or traumatic brain injury, use 500-1000 mg/day, duration of treatment is 12 months.
3. Urocoline side effects
In some patients when using Urocoline, side effects may occur such as:
Insomnia, headache, hallucinations, dizziness Rash, flushed skin, urticaria, purpura Blood pressure not stable Shortness of breath, blurred vision Nausea, vomiting, sometimes diarrhea Heart abnormalities, palpitations Edema at injection site
4. Be careful when using Urocoline:
Some notes when using Urocoline include:Note that some subjects need to be careful when using Urocoline, including: the elderly, pregnant women, lactating women, children under 15 years old, patients with liver failure, kidney failure, people with hypersensitivity to any substance in the product or subjects with myasthenia gravis, hepatic coma, stomach ulcers Caution when using Urocoline with pregnant women or breast-feeding There have been no specific reports on the effects of this product on driving or operating machinery. However, to be on the safe side, consult your doctor or pharmacist before use. Do not share Urocoline. with Levodopa because citicoline increases the effect of L-dopa Do not take drugs containing Meclofenoxate and citicoline at the same time. With the above information about the drug Urocoline will help the process of use and treatment in patients achieve effective results while minimizing unnecessary risks.
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