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Uperio 100mg belongs to a new class of drugs called neprilysin inhibitors and angiotensin receptor blockers (ARNIs). Accordingly, the drug Uperio consists of two ingredients, sacubitril and valsartan, which have special effects for people with heart failure, improving the heart's ability to pump blood around the body.
1. What is Upperio and what is it used for?
Uperio is a medicine that contains a neprilysin inhibitor and an angiotensin receptor blocker with two ingredients in one pill, sacubitril and valsartan. Uperio is indicated for the treatment of chronic heart failure in adults. This condition occurs when the heart's contractile function is weakened and it cannot pump enough blood to the lungs and the rest of the body. The most common symptoms of heart failure are shortness of breath, fatigue, decreased exercise capacity, and swollen ankles.
2. Things to know before using the drug Upio
Patients should not take Uperio if:
Are allergic to sacubitril, valsartan or any other ingredient of this medicine. Are taking another medicine called an angiotensin-converting enzyme (ACE) inhibitor (eg, enalapril, lisinopril, or ramipril). ACE inhibitors are used to treat high blood pressure or heart failure. If you are taking an ACE inhibitor, wait 36 hours after your last dose before you start taking Upio. Have you or a family member ever had a reaction called angioedema (swelling of the face, lips, tongue, and/or throat, difficulty breathing) when taking an ACEI or an angiotensin receptor blocker (ARB) such as valsartan , telmisartan or irbesartan. People with diabetes or impaired kidney function and are being treated with antihypertensive drugs containing aliskiren. Severe liver disease. Are more than 3 months pregnant (it is better to avoid this medication when there is a chance of pregnancy)
3. How to use the drug Upio?
Patients should always take the drug Uperio exactly as prescribed by the doctor or pharmacist. Check with your doctor if you are unsure. The usual starting dose for Uperio is 24 mg/26 mg or 49 mg/51 mg twice a day (one tablet in the morning and one in the evening or 1⁄2 100mg Uperio tablets each). In some cases, your doctor will decide on a higher starting dose based on previous medications. The doctor will then adjust the dose depending on how the patient responds to the initial treatment until the best dose is found.
The usual recommended target dose is 97 mg / 103 mg twice a day, i.e. one 100mg Uperio tablet in the morning and one such tablet in the evening).
Patients taking Uperio may experience low blood pressure, causing dizziness, lightheadedness; Hyperkalemia is detected by blood tests or impaired kidney function. If this happens, your doctor may reduce the dose of any other medicines you are taking at the same time, temporarily reduce the dose of Uperio, or stop treatment altogether.
When taking Uperio 100mg, the patient should swallow the tablet with a glass of water, with or without food. If you accidentally take too many Uperio tablets, contact your doctor immediately. If you experience severe dizziness or fainting, lie down and go to the nearest emergency center. If you forget to take Uperio 100mg, wait until your next dose and do not take a double dose to make up for the missed dose.
4. Possible side effects when taking Uperio
Like all other medicines, Uperio can cause side effects during use, although not everyone gets them. Some of the side effects of Uperio can be serious. Accordingly, patients should stop taking Uperio and seek immediate medical attention if they notice symptoms of swelling of the face, lips, tongue and/or throat, which may cause difficulty breathing or swallowing. These are signs of angioedema.
Other possible side effects of taking Uperio include:
Low blood pressure Increased blood potassium levels Decreased kidney function Cough Dizziness, headache Diarrhea Fatigue Feeling nauseous, vomiting Summary Uperio is a prescription medicine used to treat adults with chronic heart failure to help reduce the risk of death and acute heart failure requiring hospitalization. The benefit of Uperio was most evident in patients with a subnormal left ventricular ejection fraction. However, due to the hidden side effects, patients need to adhere to the use of Uperio 100mg exactly as prescribed by the doctor, visit and monitor periodically to control heart failure optimally.
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References: medicines.org.uk, novartis.us, england.nhs.uk
