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Umkanas belongs to the group of anti-cancer drugs whose main ingredient is anastrozole. It is commonly used to treat estrogen receptor-positive early breast cancer in postmenopausal women. So how should the drug be used?1. What is the effect of Umkanas?
The main ingredient Umkanas is anastrozole, which is a non-steroidal aromatase inhibitor. Highly selective and potent, this system converts adrenal androgens to peripheral tissue oestrogens. The drug is used in the treatment of advanced or locally advanced breast cancer, and as an adjuvant in the treatment of early breast cancer in postmenopausal women at a dose of 1 mg per day. Unresponsive drug in oestrogen-receptor negative patients. Adjuvant therapy can last up to 5 years, but the optimal duration is unknown.Regarding the pharmacokinetics of anastrozole, it is rapidly and almost completely absorbed when administered orally. Food may slightly decrease the rate of absorption of the drug, but has no clinically significant effect. Anastrozole is up to 40% bound to plasma proteins. The drug is metabolized in the liver to inactive metabolites, excreted in the urine mainly as metabolites. The pharmacokinetics of anastrozole are independent of dose and duration of administration, and are independent of the age of postmenopausal women.
Contraindications to Umkanas include:
Patients with hypersensitivity to any component of Umkanas Pre-menopausal patients Pregnant or lactating women Patients with severe renal impairment (creatinine clearance << 20 ml/min) Patients with moderate or severe hepatic impairment Oestrogen-containing therapies (because of possible loss of pharmacological effects) Concomitant administration of tamoxifen
2. Dosage of the drug Umkanas
Depending on the subjects and treatment goals, the dose of Umkanas will be different, specifically as follows:
Adults, the elderly: take a dose of 1 mg/day The disease is in the early stage, the treatment time Recommended treatment is 5 years Children are not recommended for this drug No dose adjustment is required in patients with mild or moderate impairment of renal function or in patients with mild hepatic impairment
3. Umkanas . side effects
In some patients when using Umkanas, side effects may occur such as:
Hot flashes are the most common adverse effect (mild or moderate) Weakness, muscle pain, stiffness, dryness vagina, thinning hair Rash Nausea, vomiting, diarrhea Headache, dizziness Vaginal bleeding, anorexia, somnolence, hypercholesterolemia Erythema multiforme, Steven-Johnson syndrome, elevated liver enzymes, elevated phosphatase alkaline
4. Be careful when using Umkanas
Some general notes when using Umkanas include:
Umkanas should not be used in children It is necessary to determine the menopausal status by biochemical tests in patients with suspected endocrine status No data available. To determine the safety of Anastrozole in patients with moderate or severe hepatic impairment and in patients with severe renal impairment Women with osteoporosis or at risk for osteoporosis should have their bone density evaluated with a bone densitometer prior to initiation of therapy. Initiation of therapy with Umkanas and periodically thereafter along with osteoporosis prophylaxis, as the drug can reduce blood estrogen levels, may decrease bone mineral density When oestrogen-containing therapies are co-administered with Anastrozole Can reduce the pharmacological effect of Anastrozole Taking Anastrozole at the same time as Tamoxifen may reduce the pharmacological effect of Anastrozole Be careful when using Umkanas when driving or operating machinery because the drug can cause more or less depression and drowsiness. . Above are the uses of Umkanas, users need to carefully read the instructions for use and take the medicine as prescribed by the doctor to get the best treatment results.
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