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Tytdroxil is an antibiotic indicated for the treatment of mild and moderate infections caused by bacteria sensitive to Cefadroxil, including respiratory tract, urogenital, skin and soft tissue infections.1. What does Tytdroxil do?
Tytdroxil drug contains the main ingredient is Cefadroxil, a first generation Cephalosporin antibiotic.
Tytdroxil has a medium spectrum of activity against gram-positive bacteria such as staphylococcus, streptococcus, pneumococcus (except methicillin-resistant streptococcus). Tytdroxil is also indicated for the treatment of some gram-negative bacteria such as Proteus mirabilis, Shigella, E.coli, Klebsiella pneumoniae. Tytdroxil's action is based on the inhibition of cell wall synthesis during the division phase to multiply bacteria, thereby destroying pathogenic bacteria.
The drug is quickly and almost completely absorbed orally, food does not affect the absorption of Tytdroxil. After oral administration, the drug is widely distributed in body tissues and fluids, well soluble in adipose tissue.
Tytdroxil is excreted unchanged in the urine after 24 hours.
2. Indications of the drug Tytdroxil
Tytdroxil is indicated for the treatment of the following diseases:
Acute or chronic urinary tract infections: Nephritis - pyelonephritis, cystitis, urethritis; Infections of the skin and subcutaneous tissues: lymphadenitis, abscess, cellulitis, ulcer; Pharyngitis and tonsillitis caused by group A beta-hemolytic Streptococcus; Lower respiratory tract infections: Pneumonia, exacerbation of chronic bronchitis, bronchiectasis, lung abscess, empyema, pleurisy, laryngitis; otitis media; Infections of the musculoskeletal system: Osteomyelitis, inflammatory arthritis.
3. Contraindications of Tytdroxil
Do not use Tytdroxil in the following cases:
Hypersensitivity to any antibiotic of the Cephalosporin group; Do not take with other medicines containing Cefadroxil.
4. Notes when using Tytdroxil
Patients who are allergic to penicillin should be cautious when taking Tytdroxil; Use with caution in patients with renal impairment because the drug is eliminated in the urine; Patients with gastrointestinal disease should be cautious; Prolonged use of Tytdroxil may result in overgrowth of strains of bacteria that are not susceptible to the drug; Use during pregnancy only if absolutely necessary; Tytdroxil 250 can be used during breastfeeding because it does not cross the breast milk barrier.
5. Drug interactions
Tytdroxil taken with Cholestyramine slows down the absorption of the drug in the intestine; Probenecid can reduce the elimination of Cephalosporin antibiotics; Furocemide, Aminoglycoside when combined with Tytdroxil can synergistically increase nephrotoxicity.
6. Dosage and usage
Adults:
500mg - 1g/time x 1-2 times/day. Children:
Children from 1 to 6 years old: 250mg x 2 times/day; Children over 6 years old: 500mg x 2 times/day. Dosage for patients with renal failure:
Glomerular filtration rate from 0 to 10ml/min: The interval between 2 doses is 36 hours; Glomerular filtration rate from 10 to 25ml/min: The interval between 2 doses is 24 hours; Glomerular filtration rate from 25 to 50ml/min: The interval between 2 doses is 12 hours; Glomerular filtration rate greater than 50 mL/min should be treated as patients with normal renal function. How to use:
Patients with kidney failure need to adjust the dose because the drug is excreted in the urine, so it will cause drug accumulation in the body; Tytdroxil is acid-stable and should be taken regardless of meals.
7. Tytdroxil side effects
Tytdroxil is very well tolerated at all ages. However, there are still some rare side effects as follows:
On the digestive system: Feeling of nausea, vomiting, diarrhea (less common); Anaphylactic reactions: Rash (uncommon), urticaria; Genital itching, vaginitis ; Transient leukopenia (uncommon). Tytdroxil is a first generation Cephalosporin antibiotic with broad-spectrum antibacterial activity against a number of bacteria in the body. When using Tytdroxil, you need to follow the instructions for the dose and duration of the drug. Do not arbitrarily use long-term or stop Tytdroxil because it will increase the rate of drug resistance in bacteria.
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