Uses of Trilaciclib (Cosela)

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1. Uses of Trilaciclib

The drug Trilaciclib is used to inactivate the kinase. This is not a drug that has a direct effect on cancer. The effects that the drug brings only stop at supporting and promoting the process of slowing down the growth of cancer cells. Therefore, most of the patients use Trilaciclib to reduce bone marrow suppression and detoxify the body's cells. This can also reduce the risk of secondary cancers.

2. Instructions for using Trilaciclib

Trilaciclib is administered by injection into the patient's vein. This method can limit patients' self-medication, reduce the risk of overdose or error when using. For patients prescribed to use Trilaciclib, doctors often know the specific condition of their disease. Therefore, they will consider the appropriate dose of the drug and ensure the maximum necessary effects. Thanks to their expertise and regular monitoring of a patient's progress, doctors can anticipate the risk of side effects from this drug.

3. Some notes before taking Trilaciclib

After the injection you may experience pain or burning sensation. Always do post-injection monitoring to detect vascular leaks early. Early detection of vascular leaks can reduce inflammation or serious injury.
At the injection site, follow the doctor's instructions. If you notice any signs of redness or swelling after the injection, tell your doctor and go to the nearest hospital. Unusual problems should be handled by a doctor, do not arbitrarily follow the instructions on the internet to avoid danger later.

4. Common unwanted side effects of Trilaciclib

Fatigue: Cancer patients often lose their health, so they get tired easily. Therefore, when taking drugs to treat the body, it also leads to prolonged fatigue. To limit the risk of long-term fatigue that makes the patient exhausted, you should have a reasonable rest routine. Loss of electrolytes: Minerals in the body are indispensable electrolytes. However, some metal radicals can react with the drug causing electrolyte loss. Patients should have a plan to monitor blood tests periodically to control the concentration of the drug in the blood accordingly. If electrolyte disturbances are difficult to correct, the patient may be prescribed oral or intravenous infusion to supplement. Reproductive system effects: Most drugs that inhibit kinases affect fetal development. Pregnant women who use the drug have an increased risk of birth defects because cells are inhibited from growing as normal. Therefore, you should consider stopping the drug at least 3 weeks before planning a pregnancy. Women in their menstrual cycle should inform their doctor to consider postponing Trilaciclib. For men, if taking Trilaciclib, it is necessary to pay attention to health checks to avoid reducing the ability to conceive later. Breastfeeding women should be very careful. You may be instructed by your doctor to express milk when taking the drug, but do not feed the baby and when the drug is eliminated, feed the baby again Some dangerous side effects are rare:
Although rare, the patient does not may be subjective with side effects related to the lungs or the patient is allergic to the drug Trilaciclib. Patients who have developed pneumonia after taking drugs that can adversely affect their health status. You need to pay attention to symptoms such as difficulty breathing, cough, fever... If you have signs of an allergic reaction after using the drug on your skin or body, you should go to the hospital for a checkup. Symptoms of drug allergy are usually: chest pain, difficulty breathing, swelling, rash, .....

5. Trilaciclib drug interactions

Unstable blood levels of drugs can affect the therapeutic effect of the disease. When using Trilaciclib you should not eat grapefruit or any food made from grapefruit. In addition, during drug treatment, you can notify your doctor if you are prescribed drugs that are at risk of interacting with Trilaciclib such as:
Dalfampridine; Dofetilide; Cisplatin; Metformin . For more information about Trilaciclib and how to use it most effectively, you should check with your doctor. Note that you should always evaluate and test periodically to control your body mass index while taking Trilaciclib.

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Reference source: oncolink.org