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Tiaprofenic acid is a generic drug containing the main ingredient Tiaprofenic acid. The drug belongs to the group of pain relievers, antipyretics, non-steroid anti-inflammatory drugs, drugs for the treatment of gout and bone and joint diseases containing the main active ingredient tiaprofenic acid. The following article will provide detailed information about the best uses of tiaprofenic acid, as well as how to use it.
1. What is tiaprofenic acid?
Tiaprofenic acid belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), is available in the form of tablets with strength of 300 mg and 1000 mg.
The effects of tiaprofenic acid on articular cartilage have been studied in vitro experiments and in ex-vivo studies using various animal models of arthritis. Ex-vivo experiments on human chondrocyte cell cultures were also conducted. In these experiments, tiaprofenic acid, at concentrations equivalent to therapeutic doses, did not impair the biosynthesis of proteoglycans and did not alter the differentiation of secreted proteoglycans. The breakdown of proteoglycan aggregates is inhibited. These results suggest a neutral or possibly beneficial effect of tiaprofenic acid on articular cartilage under experimental conditions. The clinical significance of these findings was investigated in a long-term double-blind study, in which tiaprofenic acid did not significantly increase the radiographic rate of joint space degradation in patients with knee osteoarthritis.
Single-dose study: After oral administration for a maximum of 90 minutes. Repeat dose study: drug elimination was rapid and no accumulation after repeated dosing of 600 mg/day in divided doses. Steady state after the first day. No malabsorption in patients with RA on long-term treatment. There is no evidence of different pharmacokinetics in the elderly.
2. What is the use of Tiaprofenic acid?
2.1. Indications for the treatment of Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, low back pain, musculoskeletal disorders such as fibromyalgia, bursitis, spondylitis and other inflammatory soft tissue conditions, Sprains and strains, inflammation and pain after surgery and other soft tissue injuries.
2.2. Contraindications Current or history of recurrent peptic ulcer/bleeding (two or more distinct episodes of ulceration or bleeding have been demonstrated)
Previous gastrointestinal bleeding or perforation, related to previous NSAID therapy Symptoms or disease of bladder or prostate activity History of recurrent urinary tract disorders Hypersensitivity to tiaprofenic acid or to any of the excipients Tiaprofenic acid is contraindicated in patients with a history of hypersensitivity reactions (eg, asthma, rhinitis, angioedema or urticaria) in response to other nonsteroidal anti-inflammatory drugs or ibuprofen or aspirin. Use in pregnant women especially in the third trimester of pregnancy: Tiaprofenic acid crosses the placental barrier. According to animal studies, there is no evidence of teratogenic potential, but the safety of tiaprofenic acid cannot be confirmed with the use of tiaprofenic acid during pregnancy and lactation in humans or with With other NSAIDs, tiaprofenic acid should not be used during the first two trimesters of pregnancy or during labor unless the potential benefit to the patient outweighs the potential risk to the fetus. In view of the known effects of NSAIDs on the fetal cardiovascular system (closure of the ductus arteriosus), use in the third trimester of pregnancy is contraindicated. The onset of labor may be delayed and the duration increased with an increased bleeding tendency in both mother and child
2.3. Drug Interactions Diuretics and hypoglycemic agents Because of highly protein-bound surgery, concomitant use with other highly protein-bound drugs such as heparin is not recommended. Dosage adjustment with diuretics, hypoglycemic agents, and phenytoin may be necessary. With oral hypoglycaemic agents, inhibition of the metabolism of sulphonylurea drugs, leading to a prolonged half-life and an increased risk of hypoglycaemia is known.
Antiplatelet agents and anticoagulants The use of Tiaprofenic acid in combination with anticoagulants is not safe due to the increased risk of bleeding.
Anticoagulants Heparin Vitamin K antagonists (e.g. warfarin) Antiplatelet agents (eg clopidogrel, ticlopidine) Antithrombotic drugs (eg dabigatran) Direct factor Xa inhibitors (eg rivaroxaban) , apixaban, edoxaban) If co-administration of these drugs with Tiaprofenic acid cannot be avoided, the patient should be closely monitored.
Other analgesics including selective cyclooxygenase-2 inhibitors Tiaprofenic acid should not be used concomitantly with other NSAIDs (including cyclooxygenase-2 - a selective inhibitor) and high doses of salicylate due to an increased risk of adverse effects. The most common side effect is upper gastrointestinal upset.
2.5. Adverse effects Gastrointestinal disorders: Very common: upper abdominal pain
Common: nausea, vomiting, dyspepsia, diarrhea
Rare: melaena, vomiting blood, anorexia, dyspepsia, heartburn, flatulence, constipation, gastritis, mouth ulcers, pancreatitis, colitis and Crohn's disease.
Gastric ulcers, bleeding and perforation of the gastrointestinal tract have occasionally been reported, especially in the elderly, and in exceptional cases have been associated with death.
Skin and subcutaneous disorders Rash, urticaria, purpura, pruritus, erythematous purpura and bullous dermatitis (Stevens-Johnson syndrome or toxic epidermal necrolysis), photosensitivity reactions light, angioedema, hair loss.
Immune system disorders Common: Nonspecific allergic reactions, bronchospasm, dyspnea
Uncommon: Hypersensitivity reactions have been reported following NSAID therapy, anaphylaxis, asthma asthma, especially in subjects allergic to aspirin and other NSAIDs
Renal and urinary disorders Uncommon: bladder pain, dysuria and hematuria, hematuria may occur
After continuous treatment , prolonged with tiaprofenic acid, urinary symptoms, urinary tract inflammation have been observed.
3. How to use the drug Tiaprofenic acid
3.1. Usage and dosage Take the drug with a lot of boiled water to cool, take the tablet whole without chewing or crushing it, it should be taken after the main meal. A course of treatment lasts 5 to 10 days. The drug is intended for adults and children 3 years of age and older who can swallow tablets.
Adults:
Attack dose: 3 times a day, 2 tablets each time Maintenance dose: 3 to 4 tablets a day, from the fourth day onwards Children from 3 years old can swallow tablets: divided into 3 days up to 4 times, each time 10mg/kg body weight/day. 3.2. Precautions when using Tiaprofenic acid There is a risk of cross-sensitivity between aspirin and non-steroidal anti-inflammatory drugs. Tiaprofenique acid should not be used in patients with a history of asthma.
Be careful when using non-steroidal anti-inflammatory drugs in infections or at risk of infection even if well controlled because the drug has the ability to reduce the body's natural resistance to infection and/or mask it. Common signs of infection.
Monitor gastrointestinal symptoms, stop treatment in case of gastrointestinal bleeding.
For long-term treatment, liver, kidney and blood function should be checked.
Discontinue treatment when vesicular rash occurs.
Above are the uses of Tiaprofenic acid for health. Please refer to the information carefully so that the use of the drug becomes more effective.
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