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Theprilda drug is made in the form of tablets, with the main ingredient in each tablet is 4mg of Perindopril erbumin and 1.25mg of Indapamide. So what is the use of Theprilda and how is it used?1. Uses of Theprilda
Perindopril is an angiotensin converting enzyme inhibitor, the action of which is obtained through the active ingredient of its metabolite, perindoprilat. In hypertensive patients, perindopril exerts its antihypertensive effect through the reduction of peripheral resistance, which usually dilates the arteries and possibly the veins.In patients with congestive heart failure, Perindopril has the effect of reducing the load on the heart, slightly reducing heart rate, and increasing cardiac output.
Indapamide is a kind of diuretic sulfonamide, it has diuretic and antihypertensive effects. This active ingredient inhibits the process of sodium ion reabsorption in the distal tubule, the excretion of sodium chloride and water. Indapamide is also effective in reducing peripheral arterial resistance. Besides, indapamide still has anti-hypertensive effect in patients without renal function.
2. Indications and contraindications to the use of Theprilda
Theprilda is indicated in the following cases:Idiopathic hypertension in adults. Theprilda is contraindicated in the following cases:
People with hypersensitivity to Perindopril or Indapamide or any other ingredient of the drug. Hypersensitivity to other ACE inhibitors. History of Quincke's edema associated with previous ACE inhibitor use. Hereditary or idiopathic Quincke's edema. Pregnant women in the 2nd and 3rd trimesters of pregnancy. If you have diabetes or kidney failure, you are taking medicines containing Aliskiren. Patients with severe renal impairment (creatinine clearance less than 30ml/min). Hepatic encephalopathy Severe liver failure Hypokalemia Patient is taking antiarrhythmic drugs causing torsade de pointes. Women who are breastfeeding. Theprilda should not be used in the following cases, due to lack of experience, including:
Patients on dialysis Patients with untreated decompensated heart failure.
2. Dosage and how to use Theprilda
Theprilda is used by mouth, patients should take it in the morning and before meals.Dosage of Theprilda drug should be according to the prescription of a specialist, the recommended dose is as follows:
Adults: Use a dose of 1 tablet per day. Elderly: Use a starting dose of 1/2 tablet/day and monitor response to medication, check kidney function. Patients with renal impairment: Mild renal impairment (creatinine clearance ≥ 60ml/min): Use normal dose and regularly check creatinine and potassium levels. Moderate renal impairment (creatinine clearance from 30-60ml/min): It is recommended to use the drug without combination, individualizing the therapeutic dose. Severe renal impairment (creatinine clearance less than 30ml/min): Contraindicated use of Theprilda. Hepatic impairment: Severe liver failure: Theprilda is contraindicated. Moderate hepatic impairment: No dose adjustment of Theprilda is required.
3. Side effects of the drug Theprilda
Common side effects of Theprilda include:Dry cough Constipation Dry mouth Nausea Epigastric pain Loss of appetite Abdominal pain Taste disturbances Uncommon side effects of Theprilda include:
Hypotension standing Hypersensitivity reactions mainly cutaneous. Allergic asthma Skin rash Cramps Less common Theprilda side effects include:
Headache Asthenia Dizziness Mental disorders Sleep disturbance Paresthesia Rare side effects of Theprilda include: :
Exacerbation of psoriasis Very rare side effects of Theprilda include:
Thrombocytopenia Leukopenia Agranulocytosis Aplastic anemia Hemolytic anemia Pancreatitis Hepatic failure Initiation of hepatic encephalopathy Quincke's edema Theprilda side effects that are being investigated include:
Severe hypokalemia Decrease sodium with hypovolemia Hyperuricemia Hyperglycemia Slight elevation of blood urea and creatinine Increased blood calcium levels If you experience Any side effects of Theprilda, should immediately notify the doctor or go to the nearest medical facility for timely support from medical staff.
4. Interactions of Theprilda with other drugs
Before using Theprilda, you need to tell your doctor about all the medicines you are taking, especially the following:Lithium Non-steroidal anti-inflammatory drugs including acetylsalicylic acid in high doses. Antidepressants similar to Imipramine. Sedative Corticosteroid Tetracosactide Other antihypertensive drugs. Potassium-sparing diuretics. Racecadotril mTOR inhibitors such as sirolimus, temsirolimus, everolimus. Hypoglycemic agents Anesthesia Allopurinol Cytostatics or immunosuppressants. Thiazide diuretics Loop diuretics. Sultopride Drugs that cause torsade de pointes. Potassium-lowering drugs. Cardiac glycosides Contrast containing iodinated calcium salts Ciclosporin . Theprilda drug is made in the form of tablets, with the main ingredient in each tablet is 4mg of Perindopril erbumin and 1.25mg of Indapamide. To ensure the effectiveness of use and avoid unwanted side effects, patients should carefully read the instructions and consult a doctor or pharmacist.
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