This is an automatically translated article.
Visartis 40 belongs to the group of cardiovascular drugs. How the drug works, dosage and instructions for use, please refer to the article below.
1. What is Visartis 40?
Visartis 40 medicine has the active ingredient Telmisartan 40mg as the main active ingredient. The drug is prepared in the form of tablets, packed in a box of 3 blisters, each blister of 10 tablets. BV Pharma - Vietnam Joint Stock Company is the unit responsible for drug production.
2. Uses of the drug Visartis 40
Drugs are often indicated in the treatment of symptoms such as:
Can be used alone or in combination with other drugs to treat essential hypertension; Support to reduce cardiovascular complications such as: stroke, myocardial infarction, and death in high-risk patients 55 years of age and older and intolerant of ACE inhibitors.
3. Effects of the drug Visartis 40 on the body
Telmisartan is a specific antagonist of the angiotensin II receptor (type AT1) in the adrenal gland and vascular smooth muscle. Angiotensin II is formed from angiotensin I by angiotensin converting enzyme (ACE) catalysis in the renin-angiotensin system. Angiotensin H is a vasoconstrictor, releasing cardiac-stimulating aldosterone and stimulating adrenal cortex synthesis. Telmisartan mainly prevents angiotensin II from binding mainly to the AT1 receptor in the adrenal gland and vascular smooth muscle causing vasodilation, reducing the effect of aldosterone. The AT2 receptor is found in many tissues, however, it is not known whether this receptor is involved in cardiovascular stability.
Compared with AT2 receptor, Telmisartan has 3000 times stronger affinity for AT1 receptor. The drug does not inhibit the breakdown of bradykinin, so does not cause the side effect of a persistent dry cough which can replace the need to stop taking ACE inhibitors because they cause coughing.
When used at a dose of 80 mg, it almost completely inhibits angiotensin H-induced hypertension in humans. This effect will be maintained for 24 hours and remains effective for up to 48 hours after taking. After the first oral dose, the antihypertensive effect appears within 3 hours. Blood pressure decreased maximally after 4 to 8 weeks of treatment and maintained throughout long-term treatment. In hypertensive patients, telmisartan also reduced diastolic and systolic blood pressure without affecting heart rate. Compared with other antihypertensive drugs, the antihypertensive effect of telmisartan is similar. However, when telmisartan treatment is stopped abruptly, blood pressure returns gradually over several days without a stronger phenomenon.
4. Effects of the body on Visartis 40
Telmisartan is rapidly absorbed from the gastrointestinal tract. When administered orally, dose-dependent absolute bioavailability was 42% and 58%, respectively, after oral administration of 40 mg and 160 mg. Food may slightly decrease bioavailability by about 6% for the 40 mg dose and 19% for the 160 mg dose.
Peak plasma concentrations occur after 30 minutes to 1 hour. More than 99% of plasma protein binding is to albumin and al- acidglycoprotein and is unchanged by dose.
Excretion is mostly via biliary tract in feces unchanged and only about 1% is excreted in the urine. The half-life is about 24 hours. The drug is metabolized to the inactive acylglucuronide conjugate. The drug does not cause accumulation when taken at the recommended dose.
In women, plasma concentrations will be about 2 to 3 times higher than in men, but no significant increase in blood pressure response or orthostatic hypotension in women can be observed, so the dose can be kept unchanged. There is no change in pharmacokinetics in subjects over 65 years of age, so no dose reduction is required in patients with mild and moderate renal impairment. Due to the high protein binding, dialysis cannot be ruled out. In patients with hepatic impairment, plasma concentrations are increased and absolute bioavailability is close to 100%. There are no pharmacokinetic studies in subjects under 18 years of age.
5. Recommended dosage and usage of Visartis 40
Cases of essential hypertension:
Onset is usually 40mg once daily; May increase to a maximum dose of 80mg once daily; Can be combined with Thiazide diuretics; It should be noted that the maximum antihypertensive effect is reached between the 4th and 8th weeks from the start of use, before increasing the dose; Do not exceed 40mg once daily in patients with mild hepatic impairment. In case of reducing the risk of cardiovascular complications:
Recommended dose 80mg/time per day; Blood pressure should be regularly monitored and dosage adjusted if necessary. The drug can be taken with or without food.
6. Contraindications Visartis 40
In case of allergy or hypersensitivity to Telmisartan or other ingredients in the drug; Do not use for women who are breastfeeding or pregnant in the last 6 months; People with severe kidney/liver failure, biliary obstruction.
7. Interaction of Visartis 40 with other drugs
Note when used with ACE inhibitors, beta-adrenergic blocking drugs because there are no data on their safety and efficacy, Telmisartan may increase the ability of these drugs to lower blood pressure; Increased serum levels of Digoxin when used concurrently with Digoxin should be carefully monitored. Dosage adjustment or discontinuation of telmisartan may be required. The hypotensive effect of Telmisartan is increased when used with diuretics; Increases the hyperkalemic effect of Telmisartan when used with potassium-sparing diuretics as well as other drugs that cause hyperkalemia; Concomitant use with Warfarin for 10 days will slightly reduce the concentration of Warfarin in the blood but not change the INR.
8. Side effects of Visartis 40
The drug is well tolerated so side effects are rare. Some effects may be encountered such as: fatigue, agitation, nausea, abdominal pain, edema of the limbs, excessive sweating, increased blood creatinine and urea nitrogen, anorexia, upper respiratory tract infection, dyspepsia , flatulence, diarrhea, angioedema, visual disturbances, tachycardia, headache, dizziness, muscle pain and muscle spasms, sinusitis.....
The above is not an exhaustive list of Side effects of the drug should be noted, if the patient appears suspected to be caused by the drug, it should be reported immediately to the doctor for the best treatment.
Above is information about uses, doses and notes when using Visartis 40 medicine. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Visartis 40 exactly as directed by your doctor.
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