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Tagimex has the main active ingredient Cimetidine 300mg. The drug is effective in the treatment of diseases of the gastrointestinal tract, such as the treatment of advanced duodenal ulcers, gastroesophageal reflux disease causing ulcers, ...
1. What is Tagimex?
Tagimex medicine has the main active ingredient is Cimetidine with a content of 300mg. Tagimex is prepared in the form of film-coated tablets, suitable for direct oral administration. Packing is a box of 10 blisters, each blister contains 10 tablets. The drug is effective in the treatment of diseases of the gastrointestinal tract, such as the treatment of progressive duodenal ulcers, gastroesophageal reflux disease causing ulcers,...
1.1. Pharmacokinetics of the active substance Absorption: The main active ingredient Cimetidine is rapidly and completely absorbed from the gastrointestinal tract. The active ingredient reaches high plasma concentrations 1 to 2 hours after oral administration. Bioavailability of the active substance orally is about 30-80%. Distribution: Binding to plasma proteins is about 50% on average. The mean half-life is 1.5 to 2.3 hours. Metabolism ability: Active substance Cimetidine through the liver about 30% and through the cerebrospinal fluid, placenta and breast milk. Elimination ability: More than 60% of the active substance is excreted by the kidneys as unchanged drug. 1.2. The effect of active ingredients Mechanism of action: Due to the similar formula to histamine, H2-histamines, specifically Tagimex, compete with Histamine at the H2 receptor in gastric parietal cells, preventing gastric secretion by other substances. causes an increase in the secretion of histamine in the stomach. Tagimex reduces both the quantity and concentration of hydrochloric acid in gastric juice. The effect of H2 receptor inhibition reduces gastric acid secretion, which is stimulated to increase secretion by histamine, gastrin, parasympathomimetic drugs and stimulant of the X nerve. The ability to reduce gastric acid secretion of the activity. Cimetidine substance is 50%. Active ingredient Cimetidine very clearly inhibits cytochrome P450 in the liver, causing antiandrogen caused by binding to the β-androgen receptor.
2. What disease does Tagimex treat?
Tagimex drug is used in the treatment of the following pathologies:
Short-term treatment:
Treatment of advanced duodenal ulcer. Low-dose maintenance treatment of duodenal ulcer after ulcer has healed. Short-term treatment of benign progressive gastric ulcer. Treatment of gastroesophageal reflux disease that causes ulcers. Treatment of pathological conditions with increased gastric secretion such as Zollinger-Ellison syndrome or multiple endocrine neoplasia. Treatment of gastrointestinal bleeding caused by peptic ulcer. Prophylaxis of upper gastrointestinal bleeding in critically ill patients.
3. Usage and dosage of the drug Tagimex
3.1. How to use Tagimex Take Tagimex with meals or at bedtime, the usual total treatment dose is not more than 2.4g/day.
3.2. Dosage of the drug Tagimex: For adults:
Treatment of gastric and duodenal ulcers: A single treatment dose of 3 tablets/day for a period of 4 weeks for duodenal ulcers and for a period of 6 weeks for ulcers stomach. The maintenance dose is 1 tablet/day. You should use the drug at night before going to bed. Treatment of gastroesophageal reflux disease: Dosage is 1 tablet / time, 4 times / day, for a period of 4 to 8 weeks. Treatment of Zollinger-Ellison syndrome: The dose is 1 tablet/time, 4 times/day, the therapeutic dose can be increased up to 2.4g/day. Treatment of upper gastrointestinal ulcers caused by prolonged psychological stress: Dosage is 1 tablet/time, every 4 to 6 hours. Prophylactic treatment of the risk of aspiration of gastric juice during anesthesia: The dose is 1 tablet/time, 90-120 minutes before anesthesia, if necessary, after 4 hours, repeat the drug. For people with renal failure:
Creatinine clearance 15-30 ml/min: Take 300mg/time, every 12 hours. The therapeutic dose can be adjusted based on the response to gastric acid secretion. Creatinine clearance < 15 ml/min: 300 mg/day. If liver failure is present, the treating physician may prescribe a further reduction in the therapeutic dose. For children: Use other dosage forms.
In case of drug overdose: When the patient takes more than 12g/day, it may produce some unwanted effects such as: pupil dilation, dysarthria, rapid pulse, agitation, disorientation, respiratory depression ... Treatment is gastric lavage, induce vomiting and treat related signs and symptoms.
4. Undesirable effects of the drug Tagimex
In the process of using Tagimex, you may experience some unwanted effects, specifically as follows:
Undesirable effects of common Tagimex:
For the digestive system: Digestive disorders a , passing loose stools. For the nervous system: Headache, dizziness, somnolence, reversible confusion, depression, agitation, restlessness, hallucinations, disorientation. For the endocrine system: Breast enlargement in men when treated with the drug for 1 month or more. Uncommon side effects of Tagimex include:
For the endocrine system: Impotence when using high doses of Tagimex for more than 1 year, but reversible. For skin: Rash, redness on the skin. For the liver: Temporary increase in liver enzymes, which disappear when stopping the drug. For the kidney: Increase the creatinine in the blood. In case of hypersensitivity, other signs may appear including: fever, allergic reactions including anaphylaxis, hypersensitivity vasculitis. Rare adverse effects of Tagimex drug, including:
For the cardiovascular system: arrhythmia, bradycardia, tachycardia, atrial - ventricular block. Blood: Decreased polymorphonuclear leukocyte count, agranulocytosis, decreased platelet count, decreased neutrophil count, pancytopenia, non-regenerative anemia. H2 antihistamines reduce acid secretion, so they also reduce vitamin B12 absorption, which can easily cause anemia. Liver: Chronic hepatitis, jaundice, liver dysfunction, pancreatitis, but resolves when the drug is stopped. Kidneys: Interstitial nephritis or urinary retention. Muscle: Polymyositis. Skin: Appears mild erythema, baldness and hair loss. Patients should proactively inform their treating doctor of any unwanted effects encountered when using this drug.
5. Interactions of the drug Tagimex
Tagimex and other H2 antagonists reduce the absorption of drugs whose absorption is dependent on gastric pH such as Ketoconazole, Itraconazole. These drugs must be taken at least 2 hours before taking a medicine containing the ingredient Cimetidine. Cimetidine can interact with many different drugs, but only a few interactions are clinically significant, especially with drugs with a narrow therapeutic index, potentially toxic, necessitating dose adjustment. treat. The majority of interactions are due to the binding of the active ingredient cimetidine to hepatic cytochrome P450 isoenzymes, particularly to CYP1A2, CYP2C9, CYP2D6 and CYP3A4, resulting in inhibition of hepatic microsomal oxidative metabolism and increased bioavailability or plasma concentrations of drugs metabolized by these enzymes. Several other interactions are caused by competition with renal tubular secretion. Drug interaction mechanisms such as changes in hepatic blood flow play a secondary role. The combination of Tagimex with these drugs should be avoided or used with caution, monitoring effects or plasma concentrations, and reducing the therapeutic dose as appropriate. Antacids can reduce the absorption of active ingredients Cimetidine if taken together, should be taken one hour apart. During treatment with Tagimex, caution should be exercised if the patient drinks alcohol or does things that require alertness, such as driving or operating machinery.
6. Some notes when using Tagimex
6.1. Contraindications of the drug Tagimex People with hypersensitivity or hypersensitivity to the active ingredient Cimetidine or any of its ingredients.
6.2. Caution when using the drug Tagimex Active ingredient Cimetidine interacts with many drugs, so when using drugs in combination with certain drugs must be carefully considered. Before using Tagimex to treat gastric ulcers, the possibility of cancer must be excluded. The reason is that when using the drug Tagimex can mask the symptoms, making it difficult to diagnose. Reduce the therapeutic dose for people with liver or kidney failure. Effects of the drug on the driver and the operation of machines: Do not use Tagimex drug for driving and operating machinery. Pregnancy: Tagimex crosses the placenta, so during pregnancy avoid using drugs containing the active ingredient Cimetidine. Lactation: Tagimex is excreted in milk and accumulates to concentrations higher than those in maternal plasma. Cimetidine-containing medicines should not be used during breast-feeding. Tagimex has the active ingredient Cimetidine 300mg. The drug is effective in the treatment of diseases of the gastrointestinal tract, such as the treatment of advanced duodenal ulcers, gastroesophageal reflux disease causing ulcers,... To ensure effective treatment and avoid side effects Unexpectedly, the patient should strictly follow the instructions of the doctor, professional pharmacist.
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