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Sullivan-400 medicine has the main active ingredient is Amisulpride 400mg and other excipients in a sufficient amount. This is a typical (1st generation) antipsychotic, used in the treatment of psychiatric disorders such as schizophrenia in adults.
1. What is the drug Sullivan-400?
Sullivan-400 medicine has the main active ingredient is Amisulpride 400mg and other excipients in a sufficient amount. This is a typical (1st generation) antipsychotic, used in the treatment of psychiatric disorders such as schizophrenia in adults.
Sullivan-400 drug is made in the form of tablets, suitable for direct oral use. Packaging is a box of 4 blisters, each blister contains 10 tablets. The main active ingredient of Sullivan-400 is Amisulpride, a 1st generation antipsychotic that has a positive effect on the signs and symptoms of schizophrenia. Accordingly, the mechanism of action of Misulpride is through its ability to inhibit presynaptic dopamine D2 and D3 receptors, increasing Dopamine release.
2. What disease does Sullivan-400 treat?
Sullivan-400 is indicated in the treatment of schizophrenia in adults.
3. Usage and dosage of the drug Sullivan-400
How to use Sullivan-400:
Sullivan-400 tablets are used orally directly, depending on the dose, it can be divided into 2 times a day (dose > 300mg/day) or 1 time (dose is > 300mg/day) dose < 300 mg/day). Dosage of Sullivan-400:
Sullivan-400 is a drug prescribed by a treating doctor, so its use must be strictly followed under the guidance of a specialist. In addition, some therapeutic doses are provided below for reference only:
For acute psychotic episodes, the usual therapeutic dose is 400-800mg/day, divided into 2 times. The dose can be adjusted according to the individual response, but the maximum recommended dose is 1200mg/day. On the other hand, for those with predominantly negative symptoms, the recommended therapeutic dose ranges from 50 to 300 mg/day. For those with both negative and positive symptoms, the therapeutic dose should be adjusted so that positive signs and symptoms are effectively controlled. In addition, the maintenance dose should be used at the lowest effective level. At the same time, the corresponding dose for people with mild - moderate renal impairment is 1⁄2 and 1⁄3 of the usual dose. In addition, there is no recommended dose for people with severe renal impairment. Missing/overdose cases:
Symptoms of Sullivan-400 overdose include somnolence, hypotension, coma and extrapyramidal symptoms. There is currently no specific antidote for amisulpride overdose. In an emergency, you need to take the person who overdosed on the drug to the nearest medical center for timely treatment. In case of missed dose: If you miss a dose of Sullivan-400, you should take it as soon as you remember as soon as possible. But if it is too close to your next dose, skip it and take your next dose at the scheduled time.
4. Undesirable effects of the drug Sullivan-400
Extrapyramidal symptoms are easy to recognize but difficult to predict precisely because it depends on the dose, drug and individual sensitivities. Extrapyramidal symptoms include:
Parkinson's symptoms (including tremors), which are more common in adults or the elderly and come on gradually. Dystrophy (abnormal facial and body movements) and dyskinesia, usually occurring in children or young adults and appearing after only a few doses of the drug. Restlessness (restlessness), which occurs after a large initial dose and resembles an exacerbation of the disease being treated. Tardive dyskinesia (rhythm, involuntary movements of the tongue, face, and jaw), usually present with long-term treatment or with high doses, but may occur with short-term treatment with high doses short. Short-term tardive dyskinesia may occur after discontinuation of Sullivan-400. Hyperprolactinemia causes clinical symptoms including: Sexual dysfunction, decreased bone mineral density, menstrual disorders, breast enlargement and lactation. Antipsychotic-induced sexual dysfunction is caused by multiple mechanisms. Decreased dopamine transport and hyperprolactinemia reduce libido, antimuscarinic effects can cause arousal disorders, and alpha, adrenergic receptor antagonism affects erection and ejaculation problems in men. During the use of Sullivan-400, if you suspect that you have sexual dysfunction caused by the drug, you should consult your doctor to consider reducing the therapeutic dose or using alternative drugs. You should proactively inform your treating doctor of any unwanted effects encountered when using Sullivan-400.
5. Some notes when using the drug Sullivan-400
Sullivan-400 is contraindicated in the following cases:
People who are in a coma. People with central nervous system depression. People with adrenal angiomas, pheochromocytoma, or prolactin-dependent tumors (pituitary prolactin tumor, breast cancer). People with signs of excessive secretion of epinephrine. Children under 18. Pregnant and lactating women. People with hypersensitivity or sensitivity to any ingredient of the drug Sullivan-400. Notes and cautions of the drug Sullivan-400:
Caution should be exercised in people at risk or suffering from cardiovascular disease, because the active substance Amisulpride has the potential to cause severe ventricular arrhythmias. Especially for people with bradycardia, hypokalemia or congenital prolongation of the QT interval. Use of Sullivan-400 may worsen Parkinson's disease in people with the disease. Furthermore, Sullivan-400 should be used with caution in people with epilepsy or at risk of convulsions, people with depression, physical weakness, prostate enlargement or people with angle-closure glaucoma. . Caution should be exercised in patients with severe respiratory failure, in those with a history of jaundice, or when laboratory findings show signs of a hematopoietic disorder. The use of Sullivan-400 is not recommended for mild to moderate psychotic symptoms in the elderly. Especially for people with dementia, amisulpride can increase the risk of death, stroke or ischemic attack. In addition, these patients are also prone to postural hypotension or changes in body temperature in hot or cold weather. Using high doses of Sullivan-400 may increase the skin's sensitivity to sunlight, so it is necessary to avoid or limit direct exposure to light while using this medicine. Similar to other antipsychotics, use of drugs containing the active ingredient Amisulpride can cause neuroleptic malignant syndrome. Therefore, when there are signs of high fever, especially for those using high doses of Sullivan-400, it is necessary to discontinue the drug. When discontinuing treatment with Sullivan-400, it is necessary to gradually reduce the dose because the active ingredient Amisulpride can cause withdrawal syndrome. It is necessary to periodically monitor the physical health of people with schizophrenia at least once a year. Amisulpride may affect reflexes, thereby affecting the ability to drive or use machines. Note for pregnant women and nursing mothers: Sullivan-400 is contraindicated for pregnant or lactating women. Note for children under 18 years: Contraindicated to use Sullivan-400 for children under 18 years old. Above is all information about the drug Sullivan-400, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy the drug Sullivan-400 to treat the disease at home, because there may be unwanted side effects on health.
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