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Samgrel drug is indicated in the prevention of thromboembolic disorders such as stroke, myocardial infarction, peripheral artery disease... Let's learn about the uses, the notes when using Samgrel through the article. down here.
1. Uses of the drug Samgrel
Samgrel drug is prepared in the form of film-coated tablets, containing the active ingredient Clopidogrel Bisulfate 75mg. Samgrel is indicated in the following cases:
Primary prevention of thromboembolic disorders such as stroke, myocardial infarction and peripheral arterial disease; Prevention and control in atherosclerotic patients with recent myocardial infarction, stroke or peripheral arterial disease.
2. Mechanism of action
Clopidogrel is a selective inhibitor of the binding of Adenosine Diphosphate to the platelet receptor, leading to ADP-mediated activation of the Glycoprotein GPIIb/IIIa complex. Therefore, the drug inhibits platelet aggregation. Clopidogrel's biometabolism is required for inhibition of platelet aggregation, acting by irreversible alteration of platelet ADP receptor, consequent binding of platelets Clopidogrel will affect the phase. posterior of platelet life. Clopidogrel is rapidly absorbed after oral administration, with peak plasma concentrations of about 3 mg/L following repeated 75 mg oral dosing. Clopidogrel and its metabolite are reversibly bound to plasma proteins (approximately 94-98%). Metabolism occurs mainly in the liver in an inactive form.Clopidogrel and its metabolites are excreted in feces and urine, the half-life of the carboxylic acid derivative is about 8 hours.
3. Dosage of the drug Samgrel
Samgrel brand name drug belongs to the group of prescription drugs, so the dose of the drug used should be prescribed by the doctor based on the patient's condition. Samgrel can be taken with or without food, some recommendations on the dose of Samgrel are as follows:
Patients with a history of atherosclerosis: Take 75mg/time/day; Prevention of thromboembolic disorders such as stroke, peripheral artery disease, myocardial infarction: Take 75mg/time/day; Acute coronary syndrome (myocardial infarction without Q wave, unstable angina): The starting dose of Samgrel is 300mg as a single dose, the maintenance dose is 75mg/day; The dose does not need to be adjusted in patients with renal impairment, the elderly. Patients should note that the dosages listed above are for reference only. The specific dose of Samgrel for each patient is prescribed by the doctor based on the medical condition.
Overdosage of Samgrel can lead to prolonged bleeding time, acute toxic symptoms are dyspnea, vomiting, fatigue and gastrointestinal bleeding.
4. Undesirable effects of the drug Samgrel
Samgrel can cause some side effects as follows:
Common: Skin allergy (skin itching, skin erythema), gastrointestinal disorders (abdominal pain, diarrhea, indigestion, nausea); Uncommon: Chest tightness and nosebleeds; Rare: Gastric ulcer, gastrointestinal bleeding, neutropenia, severe agranulocytosis, thrombocytopenic purpura, thrombocytopenia, aplastic anemia, loss of taste, disease kidney such as nephritic syndrome and acute arthritis; Frequency not determined: Intracerebral hemorrhage, thrombocytopenia, ocular haemorrhage. Patients should inform their doctor if they experience any side effects while taking Samgrel.
5. Notes when using Samgrel
Contraindicated to use Samgrel in patients with hypersensitivity to Clopidogrel or any of its components, patients with bleeding disorders such as intracerebral hemorrhage and gastrointestinal ulceration.
Use caution when using Samgrel in the following cases:
Patients with bleeding due to surgery, trauma or other diseases; Patients preparing for surgery should stop using Clopidogrel 5 days before; Clopidogrel should be used with caution in patients with bleeding lesions; Use caution when using the drug in patients with changes in metabolism, patients with liver failure; For pregnant women: There are currently no studies proving the safety of using the drug on the fetus, so only use Samgrel when absolutely necessary; For women who are breastfeeding: There are currently no studies on the excretion of Clopidogrel in breast milk, so caution should be exercised when using the drug in this population; For drivers, use machines: Clopidogrel does not affect the ability to drive or use machines.
6. Drug interactions
Aspirin: The pharmacodynamic interaction between Aspirin and Clopidogrel increases the risk of bleeding. Therefore, caution should be exercised when the two drugs are used in combination. Heparin: The risk of bleeding is increased with the combination of Clopidogrel and Heparin. Warfarin: Increased risk of bleeding when used in combination with clopidogrel. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Studies in healthy volunteers using naproxen have shown that concomitant use of clopidogrel and naproxen increases the risk of potential gastrointestinal bleeding. Therefore, caution should be exercised when clopidogrel is used in combination with non-steroidal anti-inflammatory drugs. Drugs metabolized by the cytochrome P450 enzyme system: Clopidogrel inhibits Cytochrome P450, so it may affect the metabolism of Tamoxifen, Phenytoin, Warfarin, Tolbutamide, Fluvastatin, Torsemid, non-steroidal anti-inflammatory drugs... Therefore, it should be noted. when clopidogrel is used in combination with the above drugs. Other Combination Treatments: Concomitant use of Clopidogrel with an inhibitor of the CYP2C19 enzyme may decrease the concentration of the active metabolite Clopidogrel. Therefore, caution should be exercised when clopidogrel is used in combination with CYP2C19 inhibitors such as Esomeprazole, Omeprazole, Fluoxetine, Fluvoxamine, Moclobemide, Fluconazole, Voriconazole, Ciprofloxacin, Carbamazepine, Chloramphenicol and Oxcarbazepine. Drug interactions occur that increase the risk of having an effect and reduce the therapeutic effect of Samgrel, so to ensure safety and effectiveness in treating patients, it is necessary to inform the doctor about the drugs and foods that are being used. used before taking Samgrel.
Above is all information about Samgrel drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Samgrel is a prescription drug, patients absolutely must not buy and treat at home because they may experience unwanted side effects.
