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Pageoric drug belongs to the group of gastrointestinal drugs with the main ingredient containing loperamide, which is often used to treat acute diarrhea caused by inflammatory bowel disease or to reduce stool volume in patients requiring ileostomy. So how does Pageoric work?
1. What is Pageoric?
Pageoric drug with main ingredient loperamide is a pharmaceutical containing active ingredients that bind to opiate receptors in the intestinal wall, reduce mucosal irritation and stimulate spasms of the digestive tract. The drug works to reduce intestinal peristalsis, prolonging the circulation time in the intestinal lumen. In addition, loperamide increases the tone of the anal sphincter, thereby reducing the urgency in the incontinence reflex.Because Pageoric has a high affinity for the intestine and is metabolized mainly in the first pass through the liver, it is unlikely to reach the systemic circulation. Loperamide inhibits intestinal motility due to its direct peripheral effect on the intestinal wall. Pageoric is usually indicated in the following cases:
Relief of symptoms of acute nonspecific diarrhea, chronic diarrhea caused by intestinal inflammation. Decreasing stool volume for a patient who has just had an ileostomy. Symptomatic treatment of acute diarrhea in children over 12 years of age and adults. Symptomatic treatment of acute diarrhea associated with irritable bowel syndrome in adults 18 years of age and older undergoing a preliminary diagnosis by a physician. Contraindications of the drug Pageoric:
Children under 12 years old and the elderly. Patients with acute peptic ulcer or pseudomembranous colitis caused by broad-spectrum antibiotics. Patients with acute dysentery, blood in stools and high fever. Patients with acute ulcerative colitis. Patient has invasive bacterial enteritis. Patients should avoid inhibition of intestinal motility. It should be discontinued immediately when the patient develops intestinal obstruction, constipation, distention. Patients with hypersensitivity to the components of the drug. Acute infectious diarrhea caused by bacteria capable of penetrating deep into the intestinal mucosa such as E.coli, Salmonella, Shigella. Patients with severe liver failure.
2. Dosage of the drug Pageoric
Depending on the subjects and treatment goals, the dose of Pageoric will be different, specifically as follows:
Acute diarrhea:
Adults: the starting dose is 4mg, then 2mg each time loose stools. with a maximum of 16 mg/day. Children: 2mg 3 times a day for the first day, then 1mg/10 kg after each loose stool. The total dose/day should not exceed the dose of the first day. Chronic diarrhea:
Adults: 4-8 mg/day 1 time or divided into several times. Children: The use of Pageoric has not been studied in this condition.
3. Pageoric side effects
In some patients when using Pageoric, side effects may occur such as:
Constipation Dry mouth Epigastric pain Drowsiness, dizziness, fatigue Skin rash.
4. Be careful when using the drug Pageoric
Some general notes when using Pageoric drug:
Caution when using Pageoric drug for children under 12 years of age and breastfeeding women In patients with diarrhea, the risk of electrolyte dehydration may occur at any time and it is important to have appropriate rehydration and electrolyte therapy rather than using other drugs such as Pageoric Acute diarrhea in which clinical symptoms do not improve within 48 hours should not be continued without imodium. Review of the etiology of diarrhea Patients with liver dysfunction must be closely monitored for signs of CNS toxicity, because of stage 1 metabolism AIDS patients receiving Pageoric for the treatment of diarrhea. Diarrhea should be discontinued at the onset of early symptoms such as abdominal distension When co-administered with Loperamide, co-trimoxazole may increase the bioactivity of loperamide. Pageoric drug has the main function in the treatment of gastrointestinal diseases, so in order for the drug process to have a positive effect, patients should directly discuss with their doctor and carefully read the instructions for use of the drug.
