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Lerole 40 contains the active ingredient Pantoprazole, which is indicated in the treatment of stomach diseases such as gastroesophageal reflux disease, peptic ulcer disease, prevention of stomach pain caused by non-steroidal anti-inflammatory drugs,... Learn about the uses and notes when using Lerole 40 through the article below.1. Uses of the drug Lerole 40
“What is Lerole? “Lerole 40 is made in the form of enteric coated tablets containing the active ingredient Pantoprazole 40mg. Pantoprazole belongs to the class of proton pump inhibitors. Pantoprazole irreversibly binds to the enzyme H+/K+ - ATPase on the surface of gastric parietal cells, inhibiting this enzyme and preventing the final step of gastric acid secretion. Therefore, pantoprazole is effective in inhibiting both basal gastric acid secretion and also when the stomach is irritated by any cause of irritation.Lerole 40mg is indicated in the following cases:
Treatment of gastroesophageal reflux disease (GERD); Treatment of gastrointestinal ulcers; Prophylaxis of gastric ulcers caused by the use of non-steroidal anti-inflammatory drugs (NSAIDs); Gastric hypersecretion is associated with a number of diseases (Zollinger-Ellison syndrome).
2. Dosage of the drug Lerole 40
The dose of Lerole 40 is prescribed by the treating doctor based on the patient's condition. The drug is made in the form of enteric-coated tablets, so patients absolutely do not split, chew or crush the tablet, but need to swallow the whole tablet. Some recommendations on the dosage of Lerole 40 are as follows:Treatment of gastric ulcers, gastroesophageal reflux disease: Take 1 tablet / time / day, the treatment time is usually 4 weeks. In case the ulcer has not completely healed after 4 weeks of treatment, the treatment time can be extended for another 4 weeks; Treatment of duodenal ulcer: Take 1 tablet / time / day, the treatment time is usually 2 weeks. In case the ulcer has not completely healed after 2 weeks of treatment, the treatment time can be extended for another 2 weeks; Long-term control of Zollinger-Ellison syndrome and cases of pathological hypersecretion of gastric acid: The recommended dose in the beginning of treatment is 80mg/day (2 tablets/day). The dose can then be decreased or increased depending on the patient's condition. Doses greater than 80mg/day should be divided into 2 oral doses. The duration of drug therapy depends on the clinical response of the patient. Elderly: No dose adjustment is required, however the dose of Lerole 40 should not exceed the daily dose of 40mg; Patients with renal failure: No need to adjust the dose, however the daily dose should not exceed 40mg; Patients with hepatic impairment: The metabolism of Pantoprazole in these patients is impaired, so the dose should be reduced to 1 tablet/day orally every other day; Children: There is no information on safety and efficacy in children, so Lerole 40 should not be used in the treatment of children.
3. Side effects
Lerole 40mg medicine can cause some side effects as follows:Common: Dizziness, headache, fatigue, urticaria, skin rash, nausea, dry mouth, abdominal pain, flatulence, constipation, diarrhea bleeding, joint pain, muscle pain; Uncommon: Dizziness, asthenia, dizziness, insomnia, pruritus, increased liver enzymes; Rare: Peripheral edema, diaphoresis, anaphylaxis, malaise, maculopapular rash, alopecia, acne, erythema multiforme, angioedema, belching, stomatitis, gastrointestinal disturbances, agoraphobia light, blurred vision, somnolence, insomnia, tinnitus, agitation or inhibition, paresthesia, hallucinations, eosinophilia, leukopenia, thrombocytopenia, jaundice, hepatitis, increased triglycerides, encephalopathy in patients with liver failure.
4. Note when using Lerole 40
The use of Lerole 40 is contraindicated in patients with hypersensitivity to pantoprazole or any component of the drug, in patients with malignant gastric ulcer.Use caution when using Lerole in the following cases:
Before treatment with Pantoprazole in particular as well as with proton pump inhibitors in general, the patient should be excluded the possibility of stomach cancer because the drug can mask the symptoms and delay the diagnosis of cancer; Use caution when using Lerole 40 in patients with liver disease. Because the concentration of the drug in the serum in these patients may increase slightly, reducing the elimination. Avoid using Lerole 40 in patients with severe liver failure, cirrhosis,.... Long-term treatment: Proton pump inhibitors long-term treatment (especially when used in high doses for a long time) may increase the risk of fractures of the wrist, hip, spine,... The risk increases in the elderly; An increased risk of hypomagnesium has been reported in patients treated with proton pump inhibitors for at least 3 months and in most cases for about 1 year. Symptoms of hypomagnesaemia include muscle spasms, fatigue, delirium, dizziness, convulsions, ventricular arrhythmias,... For pregnant women: Lerole 40 should not be used during pregnancy. pregnancy, except where the benefits outweigh the risks; Breast-feeding: There is no information on the safety of use in women who are breast-feeding. Therefore, only use Lerole 40 when the benefits outweigh the risks; For drivers, operating machines: Lerole 40 can cause headaches, dizziness, blurred vision, dizziness, ... so patients need to be careful when driving or operating machinery.
5. Drug interactions
Pantoprazole interacts with drugs whose absorption depends on gastric pH such as iron salts, Ampicillin esters, Ketoconazole,... increasing or decreasing the absorption of these drugs.Pantoprazole is metabolized in the liver through the cytochrome P450 isoenzyme 2C19 enzyme, so it is theoretically possible for Pantoprazole to interact with drugs metabolized by the same isoenzyme.
Concurrent use of Lerole 40 and Warfarin increases INR, prothrombin time... Risk of abnormal bleeding and death should be monitored prothrombin time and INR in case it is necessary to use use these drugs.
Sulcrat reduces absorption and bioavailability of Lerole 40, so it is necessary to take a proton pump inhibitor at least 30 minutes before taking Sucralfate.
Drug interactions occur that reduce the therapeutic effect of Lerole 40, increasing the risk of experiencing unwanted effects. Therefore, patients need to inform their doctor about any drugs and supplements they are using before treatment with Lerole 40.
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