This is an automatically translated article.
Franilax is a product of Dat Vi Phu Pharmaceutical Joint Stock Company - Vietnam. The drug with the main ingredient is Furosemide, Spironolactone should be used to treat drug-resistant edema associated with secondary hyperaldosteronism or when diuretics at usual doses have no effect.
1. What is Franilax?
Franilax drug contains the main ingredient is Spironolacton 50mg, Furosemid 20mg and excipients just enough for 1 tablet. Franilax is manufactured by Dat Vi Phu Pharmaceutical Joint Stock Company - Vietnam.
The drug is prepared in the form of film-coated tablets with specifications in a box of 3 blisters x 10 pills.
Spironolacton : This is a non-selective Androgen, Progesterone and Mineralocorticoid receptor antagonist. This active ingredient has a diuretic effect and prevents hypertension. Furosemide: This is a loop diuretic. Inhibits the co-transport system of Na+, K+, 2Cl- ions in the thick ascending limb of the loop of Henle, increases electrolyte excretion and increases water excretion. Therefore, the drug has a rapid, strong diuretic effect, accompanied by a mild decrease in blood pressure.
2. Indications and contraindications of the drug Franilax
2.1. Franilax is indicated for the treatment of drug-resistant edema associated with secondary hyperaldosteronism, including chronic congestive heart failure and cirrhosis. The drug is indicated when treatment with diuretics at usual doses has not been effective. Basal hypertension, except in patients with hyperaldosteronism. At this time, patients should only use the combination form when it is more effective than using the active ingredients separately. 2.2. Contraindications Franilax drug Franilax drug should not be used in the following cases:
Patients with hypersensitivity to any of the ingredients in the drug as well as Sulfonamides or Sulfonamide derivatives. Patients with hypovolemia Patients with impaired renal function and creatinine clearance less than 30ml/min/1.73m2 body surface, anuria. Patients with renal failure have anuria unresponsive to furosemide, renal failure due to poisoning by nephrotoxic agents, liver. Renal failure with hepatic coma, hyperkalemia, severe hyponatremia, severe hyponatremia, Addison's disease. Women who are pregnant or are breastfeeding.
3. How to use Franilax?
3.1. How to use Franilax The patient needs to take the drug orally. Accordingly, it is necessary to pay attention to take the tablet whole with a full glass of water. The ideal time to take the medicine is during breakfast or lunch.
3.2. Dosage of Franilax Adult: Take 1 - 4 tablets/day. Children: Not recommended for use. Elderly people (over 65 years old): The drug is eliminated more slowly, so it is necessary to consider and adjust the dose of the drug. The dosage of Franilax is for reference only, depending on the patient's condition, the patient will have the appropriate dose of the drug. Therefore, the patient should strictly follow the doctor's instructions on the dose and method of taking the drug.
4. How to handle when missed dose, overdose Franilax
If the patient forgets to take a dose of Franilax, take it as soon as he remembers. However, if it is almost time for your next dose, skip the missed dose and take your next dose as scheduled. Never use a double dose of Franilax to make up for it.
When using an overdose of Franilax, the patient may experience some symptoms. Accordingly, these symptoms will depend on the degree, as well as dehydration, electrolytes such as hypovolemia, dehydration, arrhythmia leading to severe hypotension, acute renal failure, blood block, delirium, flaccid paralysis, confusion, lethargy,...
How to manage overdose: Replace fluid and treat electrolyte imbalance. Prevention and treatment of serious complications caused by these conditions. In some cases, the doctor may assign the patient to perform gastric lavage and take active ingredients to reduce the absorption of drugs into the body.
5. Franilax side effects
Common side effects include:
Body as a whole: Fatigue, impotence, headache, somnolence. Endocrine: Increased prolactin, causing gynecomastia in men, menstrual disorders, impotence, hirsutism. Gastrointestinal: Gastrointestinal disturbances, diarrhea, nausea, abdominal pain. Circulation: Decrease blood volume in the case of high dose therapeutic doses, orthostatic hypotension. Less common effects include:
Skin: Urticaria, erythema, exanthema Metabolism: Decreased serum potassium, hyponatremia, hypocalcemia, hyperuricemia Neurologic: Cramping, muscle spasms Genitourinary, urinary: Increases serum creatinine. Gastrointestinal: Gastrointestinal disturbances, nausea, vomiting.
6. Franilax drug interactions
During the use of the drug Franilax may cause drug and food interactions. Therefore, caution should be taken when combining Franilax with the following drugs:
Potassium salts, non-steroidal anti-inflammatory drugs or dual RAAS blockade by the combination of ACE drugs and Angiotensin II receptor antagonists: Increases plasma concentration Serum potassium levels and hyperkalemia may occur. ACE inhibitors and Spironolactone: Hyperkalemia, especially in patients with impaired renal function. Ciclosporin: Increases serum potassium levels, even this interaction can be fatal. Cotrimoxazole: Clinically increased serum potassium. Salicylic: Increases the toxicity of Salicylic. Concomitant use of Carbenoxolone, Corticosteroids, Licorice, high-dose B2 sympathomimetics, prolonged use of laxatives, Reboxetine, Amphotericin, Amphotericin antifungals, Thiazide diuretics: Increases the risk of hypokalemia. Concomitant use with Metolazone: Increases the diuretic effect. Concomitant use with Heparin, low density Heparin: Causes severe hypokalemia. Aliskiren: Concomitant administration of these two drugs may decrease the plasma concentration of furosemide. Sucralfate: Concomitant use may reduce the absorption of furosemide from the intestine and reduce its effectiveness. Carbamazepine, Aminoglutethimide: Increased risk of hyponatremia. Concomitant use with Oestrogen, Progesteron: May reduce the diuretic effect of Furosemide. General anesthetics: Concomitant use may increase the hypotensive effect of furosemide. Concomitant use of Probenecid, Methotrexate: May reduce the effect of the drug.
7. Notes when using the drug Franilax
During the use of Franilax, patients should pay attention to the following issues:
Pregnant women: Currently, studies have not shown toxicity of Furosemide in pregnant women. However, there is also clinical evidence for the safety of the drug during the third trimester in humans. However, two active ingredients, Furosemide and Spironolactone, can cross the placental barrier. Therefore, this subject is not recommended to use the drug. If necessary, use a doctor's prescription. Lactation: Furosemide passes into breast milk and has an inhibitory effect on lactation. Cameron is a metabolite of Spironolactone, which has been found in breast milk. Therefore, Franilax is not recommended for use in nursing mothers. People who drive and operate machines: Franilax can affect the nervous system and reduce alertness and concentration. Therefore, it is necessary to be very careful when using Franilax for this subject. In addition, in the process of using Franilax, patients should also note:
This is a prescription drug, so patients only use the drug when prescribed by a doctor. People with low blood pressure should pay attention, because the drug can significantly lower blood pressure. People with gout, kidney disease, cirrhosis of the liver, and hypoproteinemia need to be very careful while taking the drug. Franilax contains Cellactose, so it should not be used by people with rare hereditary disorders of galactose, Lapp lactase deficiency, glucose - galactose disorder. In summary, the drug Franilax with the main ingredient is Furosemide, Spironolactone should be used to treat drug-resistant edema associated with secondary hyperaldosteronism or when diuretics at usual doses have no effect. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take drugs according to prescription or consult a doctor, professional pharmacist.
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