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Doniwell 25mg drug is indicated in the treatment of schizophrenia, in addition, it is also indicated to support treatment in some cases of digestive disorders. So what is the drug Doniwell 25mg? What are the uses of Doniwell 25mg?
1. What are the uses of Doniwell 25mg?
Doniwell has the active ingredient levosulpiride. This is a drug used to treat schizophrenia. Doniwell is packaged in a box containing 10 blisters x 10 tablets.
Levosulpiride is indicated for the treatment of schizophrenia, in addition, it is also indicated to support treatment in some cases of digestive disorders related to the central nervous system such as:
Vomiting, nausea; Disorders of gastric and intestinal motility; In peptic ulcer disease, the duodenum is benign.
2. How to use the drug Doniwell 25mg
2.1. How to take Doniwell 25mg Take orally.
2.2. Dosage of the drug Doniwell 25mg Adults:
Relieve symptoms of functional dyspepsia: 75mg/day, divided into 3 times. Treatment of acute and chronic schizophrenia: 200-300 mg/day, divided into 3 times. Children over 14 years: Reduce dose. Children under 14 years old: Not indicated. Patients with renal impairment: The dose should be reduced or the interval between doses increased depending on creatinine clearance.
Creatinine clearance 30 - 60 ml/min: Use 2/3 of the normal dose. Creatinine clearance 10 - 30 ml/min: Use half the normal dose. Clearance less than 10 ml/min: Use 1/3 of the normal dose. Or the interval between doses can be increased by 1.5; 2 and 3 times more than normal. However, patients with moderate to severe renal impairment should not use levosulpiride, if possible.
2.3 Handling missed dose Replenish the dose as soon as you remember it. However, if the interval between the next dose is too short, skip the missed dose and resume the dosing schedule. Do not take a double dose to make up for a missed dose.
2.4 Treatment of Overdosage Common with doses of 1 to 16 grams, but no deaths even at doses of 16 grams. Clinical symptoms vary depending on the dose used. Doses of 1 to 3 grams can cause a state of consciousness gloominess, restlessness and rarely extrapyramidal symptoms. Doses of 3-7 grams can cause more agitation, confusion and extrapyramidal syndrome. With a dose of more than 7 grams, in addition to the above symptoms may also experience coma and hypotension. In general, symptoms usually go away within a few hours. The coma seen with high doses may persist for up to 4 days.
3. Contraindications of the drug Doniwell 25mg
Doniwell is contraindicated in the following cases:
Hypersensitivity to levosulpiride or any of its ingredients. Women who are pregnant or suspected of being pregnant. Gastrointestinal bleeding, mechanical obstruction or perforation of the bowel, adrenal myeloma. Seizures, mania, or mania in schizophrenia. Breast cancer.
4. Notes when using the drug Doniwell 25mg
4.1. Caution when using antihypertensive drugs, children, the elderly: Reduce dose. Drivers or machine operators Breastfeeding women. Since the drug is mainly eliminated by the kidneys, caution should be exercised to reduce the dose and not to continue treatment in patients with severe renal impairment. Increased monitoring is recommended in patients with epilepsy because the drug may lower the seizure threshold. Can be used but should be used with caution in patients with Parkinson's disease.
4.2. Pregnancy and lactation Do not use for women who are breastfeeding, pregnant or suspected of being pregnant because the drug can cause adverse effects on the fetus as well as the health of the baby.
5. Side effects of the drug Doniwell 25mg
Common: Nervous: Insomnia or somnolence.
Endocrine: Hyperprolactinemia, increased lactation and menstrual disorders or amenorrhea.
Uncommon: Neurological: Overstimulation, extrapyramidal syndrome (restlessness, torticollis, eye rotation), Parkinson's syndrome.
On the heart: Prolonged QT interval (causing arrhythmias, torsades de pointes).
Above is the information about the drug Doniwell 25mg, knowing the dosage and usage will help the treatment process bring the best effect to the patient's health. If you have any further questions, you can talk to your doctor for further advice.
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