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Tazicef medicine has the main active ingredient Ceftazidime and other excipients in a sufficient amount. Tazicef belongs to the class of antibiotics with anti-parasitic, anti-bacterial, anti-viral and anti-fungal effects.
1. What is Tazicef?
Tazicef medicine has the main active ingredient Ceftazidime and other excipients in a sufficient amount. Tazicef belongs to the class of antibiotics with anti-parasitic, anti-infective, anti-viral and anti-fungal effects. Tazicef is prepared in the form of a powder for injection, suitable for intravenous or intramuscular administration. Packing is a box of 10 vials or 100 vials x 1g
1.1. Pharmacodynamics of active ingredient Ceftazidime Main active ingredient Ceftazidime is a 3rd generation Cephalosporin antibiotic with bactericidal effect caused by inhibition of bacterial cell wall synthesis enzymes.
1.2. Pharmacokinetics of the active ingredient Ceftazidime Absorption: Active active ingredient Ceftazidime is not absorbed from the gastrointestinal tract, so it is usually used intravenously or intramuscularly. Distribution: only about 10% of the drug is bound to plasma proteins. Active ingredient Ceftazidime penetrates deep tissues and peritoneal fluid. The drug reaches therapeutic concentrations in the cerebrospinal fluid when the meninges are inflamed. Ceftazidime crosses the placenta and is excreted in breast milk. Metabolism: Active substance Ceftazidime is not metabolised. Elimination: About 80-90% of the dose of Ceftazidime is excreted in the urine after 24 hours. The mean renal clearance of Ceftazidime is 100 ml/min. Ceftazidime is excreted in bile less than 1%. 1.3. The effect of active ingredient Ceftazidime Active ingredient Ceftazidime has a bactericidal effect caused by inhibiting enzymes that synthesize bacterial cell walls. Ceftazidime is relatively stable to most bacterial beta-lactamases except Bacteroides enzymes. This active substance is sensitive to many aminoglycoside-resistant gram-negative bacteria and to many gram-positive bacteria resistant to Ampicillin and other Cephalosporins.
2. Tazicef is used to treat what diseases?
What does Tazicef do? Tazicef is indicated for treatment in the following cases:Only use Tazicef in very severe infections, which have been treated with conventional antibiotics and have not improved to limit drug resistance. Severe infections caused by Gram-negative bacteria such as bacteremia, meningitis, urinary tract infections with complications; lower respiratory tract infections, bone and joint infections, gynecological infections; intra-abdominal infection; Skin and soft tissue infections including burns and wound infections. The above infections have been confirmed or suspected to be caused by Pseudomonas or Staphylococcus bacteria such as Pseudomonas meningitis, infections in people with reduced neutrophil counts, requiring the combination of ceftazidime antibiotics with other types of antibiotics. other antibiotics.
3. Usage and dosage of Tazicef
3.1. Dosage of Tazicef For adults: The average therapeutic dose is lg deep intramuscular or intravenous (depending on the severity of the disease) every 8 to 12 hours. The therapeutic dose is increased to 2g in the treatment of meningitis caused by gram-negative bacteria and immunocompromised diseases.
For the elderly over 70 years old: The dose of 24 hours should be reduced to % of the dose of normal people, up to 3g/day.
For young children and children:
Children over 2 months old, the usual dose is 30-100 mg/kg/day divided into 2-3 times, (8 or 12 hours apart). The doctor may prescribe to increase the treatment dose to 150 mg/kg/day (up to 6g/day) in 3 divided doses for very severe cases. Infants and children under 2 months of age, the therapeutic dose is 25-60 mg/kg/day divided into 2 doses, 12 hours apart (for infants, the half-life of active ingredient Ceftazidime has 3 to 4 times higher than adults In case of meningitis in children over 8 days old, the usual dose is 50 mg/kg administered every 12 hours. Age-related: Based on creatinine clearance less than 50 mg/min, the therapeutic dose should be reduced.
3.2 Cases of overdose and management Some of the reactions of Tazicef overdose include seizures, pathology, brain, tremor, neuromuscular excitability. Hemodialysis or peritoneal dialysis may be given for rapid drug elimination.
4. Undesirable effects of Tazicef
Undesirable effects of Tazicef, the most common local reactions after intravenous injection are allergies, local irritation, thrombophlebitis; maculopapular rash, exanthema.
Uncommon side effects of Tazicef, specifically:
For the whole body: Headache, dizziness, fever, Quincke's edema, anaphylactic reactions. Blood: Increased eosinophil count, decreased platelet count, decreased white blood cell count, decreased neutrophil count, increased lymphocyte count, positive Coombs reaction, For the nervous system: Sensory dysesthesia taste disorder. For patients with renal failure, improper treatment may cause convulsions, encephalopathy, tremor, neuromuscular stimulation; For the digestive system: Nausea, vomiting, abdominal pain, diarrhea Rare adverse effects of Tazicef:
Blood: Agranulocytosis, hemolytic anemia; For the digestive system: Pseudomembranous colitis; Skin: Erythema multiforme, Steven - Johnson syndrome or toxic skin necrosis; Liver: Increase transaminase index, increase alkaline phosphatase index; For the genitourinary system: Decreased glomerular filtration rate, increased plasma urea and creatinine, and possible risk of superinfection with Enterococci and Candida. You need to proactively notify the treating doctor of any unwanted effects encountered when using the drug. With mild adverse reactions, usually only discontinuation of the drug is necessary. In case of severe hypersensitivity or allergic reaction, the doctor may prescribe supportive treatment (ensure ventilation and use Epinephrine, breathe oxygen, use antihistamines, corticosteroids...) .
5. Tazicef drug interactions
5.1. Interactions of Tazicef Drugs Tazicef interacts with aminoglycosides or strong diuretics such as furosemide, ceftazidim causing high nephrotoxicity, renal function should be monitored when using long-term treatment. Chloramphenicol is antagonized in vitro with the active substance Ceftazidime and should be avoided when bactericidal action is required. 5.2. Incompatibilities of Tazicef: With sodium bicarbonate solution: Reduce the effect of Tazicef. Do not mix the drug containing the active ingredient Ceftazidime into the solution with a pH above 7.5 (do not mix the drug into the sodium bicarbonate solution). Combination of Tazicef with Vancomycin must be used separately because it causes precipitation. Do not mix drugs containing ceftazidime with aminoglycosides, specifically Gentamicin, Streptomycin or Metronidazol. The catheters and syringes should be carefully rinsed with saline (0.9% sodium chloride) between administrations of these two drugs, to avoid precipitation.
6. Some notes when using Tazicef
6.1. Contraindications of Tazicef: People who are sensitive or allergic to Ceftazidime or Cephalosporin antibiotics.
6.2. Precautions while using Tazicef Before starting treatment with the antibiotic Ceftazidime, carefully investigate the patient's history of allergy to Cephalosporins, penicillins or other drugs. According to studies, there is a cross-reactivity between Penicillin and Cephalosporins. Although Tazicef is not nephrotoxic, caution must be exercised when co-administered with nephrotoxic drugs. Some Enterobacter strains that are initially sensitive to Tazicef may develop resistance during treatment with ceftazidime and other cephalosporins. Tazicef may decrease blood clotting time. You need to pay attention to monitor blood clotting time for people with kidney failure, liver failure, malnutrition and if necessary, give vitamin K. Daily therapeutic dose should be reduced when used for patients with renal failure. Use caution when prescribing Tazicef to people with a history of gastrointestinal disease, especially dysentery. Effects of the drug on drivers and use of machines: No significant influence should be able to use the drug. Pregnancy: Cephalosporin antibiotics are considered safe during pregnancy. However, there are no adequate and well-controlled studies in pregnant women. Therefore, Tazicef should only be used during pregnancy when absolutely necessary. Lactation: Tazicef is excreted in milk, affecting breast-feeding infants. In addition, you also need to consider this issue when starting treatment, when changing therapy or when taking Tazicef with alcoholic beverages such as beer or wine.
Above is all information about Tazicef, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy Tazicef to treat diseases at home, because there may be unwanted side effects to health.
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