This is an automatically translated article.
The drug TanacotrimF has the main ingredients Sulfamethoxazol and Trimethoprim, commonly used in the treatment of bacterial infections. Let's learn about the use of TanacotrimF in the article below.
1. What is TanacotrimF?
TanacotrimF is manufactured by Thanh Nam Pharmaceutical Manufacturing and Trading Co., Ltd., Vietnam and circulated on the market with registration number VD-24649-16. TanacotrimF is a prescription medication that contains the main active ingredients Sulfamethoxazol and Trimethoprim.
Dosage form: Tablets, each containing 800mg Sulfamethoxazol, 160mg Trimethoprim and other excipients of the manufacturer.
Packing form: Blister of 10 tablets, each box includes 10 blisters and instruction sheet.
2. Uses of the drug TanacotrimF
Pharmacodynamics:
Active ingredient Trimethoprim has bacteriostatic effect by inhibiting the bacterial enzyme dihydrofolate - reductase. Trimethoprim is effective against urinary tract bacteria such as E. coli, Enterobacter, Klebsiella, Proteus, Staphylococcus saprophyticus, Streptococcus faecalis, ...
The use of Trimethoprim in Vietnam is not widespread, so there are no statistical data. specifying drug resistance and susceptibility. Pseudomonas aeruginosa and Trimethoprim-resistant Gonococcus.
Pharmacokinetics:
Absorption: Trimethoprim is rapidly and almost completely absorbed orally. The drug concentration peaks in the blood within 1 - 4 hours after oral administration. Distribution: Trimethoprim is widely distributed in tissues and fluids including kidney, liver, lung, bronchial fluid, ocular aqueous humor, saliva, vaginal fluid, prostate gland. The binding rate of Trimethoprim to plasma proteins is 45%. Trimethoprim crosses the placenta and is present in breast milk. Elimination: The half-life of Trimethoprim is 8-11 hours, which is reduced in children and prolonged in renal failure and neonates. Trimethoprim is excreted mainly by the kidneys and can be removed from the blood by dialysis.
3. Indications and contraindications of the drug TanacotrimF
Drug TanacotrimF is usually indicated in the following cases:
Respiratory tract infections such as acute exacerbation of chronic bronchitis, otitis media, acute pneumonia, cheek sinusitis. Urinary tract infections . Gastrointestinal infections. Welding. Pneumocystis carimii infection: Pneumocystis carinii pneumonia. Contraindicated in the following cases:
Hypersensitivity to any component of TanacotrimF. Megaloblastic anemia due to folic acid deficiency. Renal failure that can monitor drug levels in the blood. Children under 2 months old.
4. Dosage and how to use TanacotrimF
TanacotrimF is a prescription drug, so patients can only use it when prescribed by a doctor and must adhere to the treatment schedule, not to quit smoking, change the dosage and route of medication. At the same time, TanacotrimF should not be shared with others or given to others to use even if they have the same diagnosis.
Dosage:
Treatment of urinary tract infections:
Uncomplicated lower urinary tract infections: Adults take 1 tablet / time x 2 times / day, the interval between doses is 12 hours, used in 10 days. Or can use 2 tablets / time, the minimum treatment time is 3 days or 7 days. Children: dose 8mg Trimethoprim/kg + 40mg Sulfamethoxazol/kg, divided into 2 doses 12 hours apart, used for 10 days. Chronic recurrent urinary tract infections in adult women: 40mg Trimethoprim + 200mg Sulfamethoxazole daily or 2-4 times this dose, 1-2 times a week. Treatment of acute exacerbation of chronic bronchitis:
Use dose 800 - 1200mg Sulfamethoxazol + 160 - 240mg Trimethoprim, 2 times / day x 10 days. Treatment of acute otitis media, acute pneumonia in children:
8mg of Trimethoprim/kg + 40mg of Sulfamethoxazole, 2 times a day 12 hours apart, for 5-10 days. Treatment of gastrointestinal infections:
Bacillary dysentery: Adults: 1 tablet/time x 2 times/day x 5 days, the interval between doses is 12 hours. Children: 8mg Trimethoprim/kg + 40mg Sulfamethoxazol/kg in 24 hours, divided into 2 divided doses 12 hours apart. Treatment of pneumonia caused by Pneumocystis carinii:
20mg Trimethoprim/kg + 100mg Sulfamethoxazol/kg in 24 hours, divided equally 6 hours apart, used 2-3 weeks. The dose of TanacotrimF should be adjusted in patients with renal impairment. Do not use the drug when the creatinine clearance is < 15 ml/min.
How to use: TanacotrimF is prepared in the form of tablets and taken orally. Take the tablet with an adequate amount of water, do not crush or chew the tablet.
How to deal with a missed dose of TanacotrimF?
When you miss a dose, you can take another dose instead. If it is almost time for your next dose, skip the missed dose, skip an extra dose, or double it to make up for the missed dose. How to deal with an overdose of TanacotrimF?
Overdose of TanacotrimF can cause nausea, vomiting, loss of appetite, headache, unconsciousness, hematopoietic disorders, jaundice, myelosuppression. When an overdose is suspected, it is necessary to quickly bring the patient to the nearest hospital for timely emergency treatment. Can induce vomiting, rinse the patient's stomach, acidify the urine to increase the excretion of TanacotrimF from the body. If there is evidence of myelosuppression, the patient should be given Leucovorin at a dose of 5-15 mg/day until hematopoietic recovery.
5. Undesirable effects
In addition to the therapeutic effect, the drug TanacotrimF may cause some unwanted effects during use.
Take the patient to the nearest hospital immediately if there are signs of an allergic reaction after taking the medicine such as redness, hives, swelling of the face, lips, throat, tongue, difficulty breathing, sweating, rapid pulse, low blood pressure , pressure, ...
Undesirable effects of TanacotrimF such as:
Common: Vomiting, nausea, diarrhea, fever, glossitis, rash, fever. Uncommon: Leukopenia/neutropenia, eosinophilia, purpura, urticaria. Rare: Anaphylaxis, serum sickness, hemolytic anemia, megaloblastic anemia, thrombocytopenia, agranulocytosis, pancytopenia, aseptic meningitis, toxic epidermal necrolysis , Stevens-Johnson syndrome, erythema multiforme, angioedema, photosensitivity, cholestatic jaundice, hepatic necrosis, hyperkalemia, hypoglycemia, renal failure, renal colic, interstitial nephritis, hallucinations, Tinnitus. These are not all side effects of TanacotrimF, patients may experience other side effects that have not been reported or studied. Therefore, contact your doctor as soon as you have any unusual symptoms while using TanacotrimF.
6. Drug interactions
Treatment with many drugs can cause interactions between components that affect the bioavailability, effects, and toxicity of the drug. In addition, some diseases such as immunodeficiency, liver failure, kidney failure,... can also affect the effectiveness of the drug.
Therefore, in order to use TanacotrimF safely and effectively, patients need to list and inform their doctor about all medications they are taking as well as their current health status. At the same time, it is necessary to discuss with the doctor about the use of certain foods and drinks such as alcohol, stimulants, and fermented foods during treatment with TanacotrimF.
Drugs that can interact with TanacotrimF such as:
Diuretics, especially Thiazides: Increases the risk of thrombocytopenia in the elderly. Sulfonamides can inhibit protein binding and renal excretion of methotrexate, thereby reducing elimination, increasing the effect of methotrexate. Cotrimoxazol with pyrimethamine 25mg/week increases the risk of megaloblastic anemia. Cotrimoxazole inhibits the hepatic metabolism of Phenytoin and may therefore unduly potentiate the effects of phenytoin. Cotrimoxazole may prolong the prothrombin time in patients taking the anticoagulant Warfarin.
7. Some notes when using TanacotrimF
Use of TanacotrimF during pregnancy: Sulfonamides can cause jaundice in perinatal children due to full bilirubin out of albumin. Therefore, only use TanacotrimF during pregnancy when absolutely necessary and must take additional folic acid.
Use of TanacotrimF during lactation: Newborns are very sensitive to the skin toxicity of TanacotrimF, so pregnant women should not use TanacotrimF.
The effect of TanacotrimF on the ability to drive and use machines has not been reported.
Use caution when using TanacotrimF in the following subjects: People with impaired renal function, folic acid deficiency, long-term use of high doses of Cotrimoxazol, dehydration, malnutrition, G6PD deficiency.
8. Preservation of drugs
Store TanacotrimF in the original manufacturer's packaging, in a cool, clean place, the temperature is below 30 degrees Celsius. Avoid direct exposure to sunlight, reach of children as well as pets. TanacotrimF has a shelf life of 36 months, do not use drugs that have expired or show signs of change in color, properties, taste, no labels. Do not throw TanacotrimF down the toilet or plumbing unless told to do so. Above is all information about TanacotrimF drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, TanacotrimF is a prescription drug, patients need to use the drug as prescribed by the doctor, absolutely do not self-treat at home.
