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Tacrolimus Teva 0.5mg medicine has the main active ingredient Tacrolimus. This drug belongs to the group of drugs that treat cancer and affect the immune system.
1. What is Tacrolimus Teva 0.5mg?
What is Tacrolimus Teva 0.5mg? Tacrolimus Teva 0.5mg contains the active ingredient Tacrolimus. This drug belongs to the group of drugs that treat cancer and affect the immune system.
Dosage form of Tacrolimus Teva 0.5mg is a hard capsule, suitable for oral use. Packing is a box of 5 blisters, each blister contains 10 pills.
Tacrolimus is a macrolide (macrolactam) extracted from Streptomyces tsukubaensis, with potent immunosuppressive activity similar to cyclosporin pharmacologically but structurally unrelated; The drug also has antibacterial activity, but it is still very limited. The exact mechanism of the immunosuppressive action of tacrolimus is unknown.
2. What is Tacrolimus Teva 0.5mg used to treat?
Tacrolimus Teva 0.5mg medicine is used in the treatment of the following pathology:
Prophylactic treatment of transplant type for recipients of liver, kidney or heart transplants. Transplant therapy for transplant recipients resistant to other immunosuppressive agents.
3. Usage and dosage of Tacrolimus Teva 0.5mg
3.1. Usage of the drug Tacrolimus Teva 0.5mg Tacrolimus Teva 0.5mg is prepared in the form of hard capsules, suitable for direct oral use.
3.2. Subjects using the drug Tacrolimus Teva 0.5mg Information on subjects using the drug Tacrolimus-Teva 0.5mg as prescribed by the treating doctor.
3.3. Dosage of Tacrolimus Teva 0.5mg When to take the drug: You should take Tacrolimus Teva 0.5mg on an empty stomach or at least 1 hour before or 2-3 hours after a meal for maximum absorption. For liver transplant recipients: The initial therapeutic dose is 100-200 mcg/kg daily, divided into 2 doses. For heart transplant recipients: The initial therapeutic dose is 75 mcg/kg daily in 2 divided doses. For kidney transplant recipients: The initial therapeutic dose is 150-300 mcg/kg per day in 2 divided doses. For children receiving liver and kidney transplants: The initial therapeutic dose is 300 mcg/kg per day, divided into 2 doses. Use this medicine within about 6 hours of completing a liver or heart transplant and within 24 hours of completing a kidney transplant. The maintenance dose should be adjusted according to the individual trough tacrolimus whole blood or plasma concentrations. The majority of drug users have a good response when maintaining whole blood levels below 20 ng/ml. Children usually need a therapeutic dose 1.5 - 2 times larger than the adult therapeutic dose to achieve the same drug concentration in the blood.
3.3. Cases of overdose and treatment Currently, there is not enough information on overdose of Tacrolimus Teva 0.5mg. Symptoms of overdose may include tremor, headache, nausea and vomiting, infection, urticaria, lethargy, increased blood urea nitrogen, increased serum creatinine, and increased alanine aminotransferase levels.
Currently there is no specific antidote for Tacrolimus Teva 0.5mg overdose. In the event of an overdose, your doctor will treat you symptomatically and provide other support as needed.
4. Undesirable effects of Tacrolimus Teva 0.5mg
Undesirable effects of Tacrolimus Teva 0.5mg drug may occur as follows:
Tacrolimus Teva 0.5mg drug can cause neurotoxicity and nephrotoxicity. The most common undesirable effects are tremors of hands and feet, headache, paresthesia; nausea and diarrhea; hypertension, leukocytosis, renal failure, anemia, decreased white blood cell count, decreased platelet count. In addition, you may also experience electrolyte disturbances, increased potassium in the blood. Uncommon side effects: mood swings, sleep disturbances, confusion, dizziness, tinnitus, visual disturbances, convulsions; disorders of carbohydrate metabolism, diabetes; ECG changes and tachycardia, myocardial hypertrophy (especially in children); constipation, indigestion, gastrointestinal bleeding; shortness of breath, asthma, pleural effusion ; excessive hair loss, hirsutism, rash and itching; aching joints or muscle aches, cramps; peripheral edema, liver dysfunction, coagulation dysfunction. You need to inform your doctor about the unwanted effects encountered when using Tacrolimus Teva 0.5mg.
5. Tacrolimus Teva 0.5mg . drug interactions
Interactions of Tacrolimus Teva 0.5mg may occur as follows:
Renal toxicity is increased when Tacrolimus Teva 0.5mg is used together with potentially nephrotoxic drugs (ciclosporin), so the combination should be avoided. Tacrolimus Teva 0.5mg should not be combined with potassium-sparing diuretics. Tacrolimus Teva 0.5mg is metabolised via cytochrome P450 isoenzyme CYP3A4. These enzyme inhibitors such as azole antifungals, bromocriptine, calcium channel blockers, cimetidine, some corticosteroids, Cyclosporin, danazol, HIV-protease inhibitors, Delavirdin, Macrolide antibiotics and Metoclopramide may increase plasma concentrations. active substance Tacrolimus in the blood. Grapefruit juice also inhibits the metabolism of Tacrolimus Teva 0.5mg and should be avoided. Drugs that induce the cytochrome P450 isoenzyme CYP3A4 such as carbamazepine, nevirapine, phenobarbital, phenytoin and rifampicin may decrease blood levels of Tacrolimus. Avoid use of live attenuated vaccines during immunosuppressive therapy including treatment with Tacrolimus Teva 0.5 mg because of the increased risk of infection.
6. Some notes when using Tacrolimus Teva 0.5mg
6.1. Contraindications of Tacrolimus Teva 0.5mg Do not use Tacrolimus Teva 0.5mg in the following cases:
People with hypersensitivity or hypersensitivity to the active ingredient Tacrolimus or to other Macrolides. People with hypersensitivity to any of the excipients of the drug. 6.2. Precautions while using Tacrolimus Teva 0.5mg Dosage adjustment may be necessary in patients with hepatic impairment and in patients with pre-existing renal impairment. Monitor blood levels of the active ingredient Tacrolimus in all users of the drug. During the initial post-transplant period, the following parameters should be monitored: blood pressure, ECG, neurological and visual status, blood glucose, electrolytes (especially potassium), liver and kidney function tests, complete blood count, coagulation indices and plasma proteins. If the user's condition changes clinically, adjustment of immunosuppressive therapy should be considered. As with other immunosuppressive drugs, the use of Tacrolimus Teva 0.5mg increases the risk of infection and malignancy. Intrauterine devices should be used with caution during immunosuppressive therapy because of the increased risk of infection. Keep Tacrolimus Teva 0.5mg out of the reach of children. 6.3. Use in pregnancy and lactation For pregnant women: Tacrolimus Teva 0.5mg crosses the placenta, but there are no adequate studies on its effects on the fetus. In maternal use of drugs containing the active ingredient Tacrolimus, hyperkalemia and renal damage have occurred in the neonate. Therefore, extreme caution should be exercised when using Tacrolimus Teva 0.5mg for pregnant women, only when absolutely necessary. For lactating women: Tacrolimus Teva 0.5mg is distributed into breast milk. Therefore, the mother should stop breastfeeding when taking medicines containing the active ingredient Tacrolimus. 6.4. Using the drug with drivers or operating machines: Tacrolimus Teva 0.5mg can cause many effects on nerve function and vision, especially when taken with alcohol. You should avoid driving or operating dangerous machinery if you are affected by these undesirable effects.
Above is all information about Tacrolimus Teva 0.5mg, patients need to carefully read the instructions for use, consult a doctor / pharmacist before use. Absolutely do not arbitrarily buy Tacrolimus Teva 0.5mg to treat diseases at home, because there may be unwanted side effects on health.
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