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Sorafenib is used to treat cancer of the liver, kidney, and thyroid. This is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.
1. What is Sorafenib?
Sorafenib is also known as Nexavar. Drugs are a type of targeted therapy in cancer treatment. The therapy is understood to work by targeting specific receptors on cancer cells, thereby reducing unwanted effects caused by damage to healthy cells.Kinase is an enzyme that promotes cell growth. There are many types of kinases, which control different stages of cell development. Sorafenib actually works by targeting the RAF kinase and VEGF receptors. Blocking the RAF kinase receptor slows cell division and tumor growth.
2. How to use Sorafenib
Sorafenib is available in the form of tablets for oral administration. Sorafenib is usually taken twice a day and should be taken on an empty stomach, 1 hour before or 2 hours after a meal. Take Sorafenib at the same time each day.
In case of missed dose, skip the missed dose and take the next dose at the scheduled time. Never double your next dose.
3. Sorafenib drug interactions
Blood levels of Sorafenib can be affected by certain foods and drugs, so their combined use should be avoided. These drugs include: Warfarin ; Carbamazepine, Rifampin, Phenytoin and Phenobarbital. To limit possible adverse drug interactions, you should list all medications and supplements you are taking to your doctor.
4. How to store Sorafenib
In case of self-storage:
Store Sorafenib in its original, labeled packaging at room temperature and in a dry place (unless otherwise directed by your treating physician or other healthcare professional). Keep the medicine container out of the reach of children and pets. Do not flush the tablet or its packaging down the toilet. In case of caregiver:
Caregivers avoid touching the pill. Wear gloves when dispensing medication to a patient. Caregivers need to wash their hands before and after giving you medicine. Pregnant or nursing women should not prepare a dose for you.
5. Undesirable effects of the drug Sorafenib
Here are some common side effects when using Sorafenib:
High blood pressure: Sorafenib can cause high blood pressure. You should actively monitor your blood pressure during the first 6 weeks of treatment and periodically thereafter. Feeling tired: Fatigue is a very common feeling during cancer treatment. At times, you can feel exhausted, which doesn't improve with rest. Diarrhea: Your doctor may prescribe medications to reduce diarrhea. Decreased appetite: Cancer treatment can affect your appetite, and in some cases, unwanted effects of treatment can cause a decrease in appetite. Try to eat 5 or 6 small meals; avoid eating foods that you think smell or taste bad; Use extra spices like basil, oregano or rosemary for extra flavor. Nausea or vomiting a lot: When you experience nausea or vomiting a lot, talk to your doctor for the right solution. Hand-foot syndrome: Hand-foot syndrome is understood as a skin reaction appearing on the palms and/or soles of the feet, caused by certain chemotherapeutic agents being absorbed by skin cells. This syndrome may begin as a slight tingling, numbness, tingling, redness or pain or swelling of the hands and/or feet. This condition can then lead to painful swelling, blistering, or peeling of the skin that can interfere with your ability to function normally. Mouth ulcers or mucositis: Some cancer treatments can cause sores or sores in your mouth and/or throat. Mucositis is characterized by symptoms such as your mouth, tongue, inside of your cheeks or throat becoming white, sore, or sore. Taking regular oral care measures can help prevent or control mouth sores. If mouth sores become painful, doctors may prescribe pain relievers. Skin and nail changes: Some people may develop a rash, very dry or itchy skin during treatment with Sorafenib. Your nails may become dark, break easily, or fall off. While using Sorafenib, the hair on your head may become frizzy, thin, or brittle. These undesirable effects tend to subside after discontinuation of treatment. Less common side effects:
Slow wound healing: Sorafenib may lead to slower or incomplete wound healing, such as non-healing or non-healing surgical wounds. Gastrointestinal perforation: Sorafenib can cause a tear in the intestinal wall, also known as a gastrointestinal perforation. Signs of a gastrointestinal perforation may include: new or worsening abdominal pain, chills, fever, constipation, nausea or vomiting. TSH levels in thyroid cancer treatment : People with thyroid cancer may need to have their TSH levels monitored more often while using Sorafenib . Complete blood count: Your blood count may be affected by this treatment. This can cause a lower white blood cell count.
6. Effects of Sorafenib on fertility
Exposure to sorafenib can cause birth defects, so you should not become pregnant or father a child while using this medicine. The use of safe contraception is essential during treatment and for at least 6 months after treatment for women and 3 months after treatment for men. For women who are breast-feeding: You should not breast-feed for about 2 weeks after finishing treatment with Sorafenib. Sorafenib is a prescription drug, so make sure you consult your doctor before using it. Hopefully the article has provided you with useful information about the uses, dosage and precautions when using Sorafenib.
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