This is an automatically translated article.
Sindoxplatin medicine 100mg is often prescribed by doctors to treat colon cancer or metastatic colorectal cancer. In order to achieve the desired results of treatment, patients need to ensure that they strictly follow all the drug recommendations given by the doctor.
1. What is Sindoxplatin 100mg?
Sindoxplatin 100mg belongs to the group of anti-cancer drugs and has an effect on the body's immune system, often used in the treatment of cancer of the digestive tract, such as colon cancer. Sindoxplatin 100 is manufactured by Actavis Italy S.P.A - Italy, the main dosage form is lyophilized powder mixed with solution for injection, each box contains a vial of 100mg content.
The main active ingredient in Sindoxplatin is Oxaliplatin. Each vial of Sindoxplatin contains 100mg of Oxaliplatin to be reconstituted in approximately 20ml of solvent.
2. What are the effects of Sindoxplatin 100mg?
2.1 Uses of the drug Sindoxplatin 100mg Active ingredient Oxaliplatin belongs to the group of new platinum compounds (anti-neoplastic drugs), has a broad spectrum of cytotoxicity in vitro and antitumor activity on many types of tumors such as colorectal tumors. colon in vivo. In addition, Oxaliplatin is also active against some cisplatin-resistant cancers.
2.2 Indications to use Sindoxplatin 100mg Sindoxplatin 100 is usually prescribed by doctors for the following cases:
Adjuvant treatment for patients with stage III colon cancer after surgical resection remove the entire primary tumor. Treatment of patients with metastatic colorectal cancer. 2.3 Contraindications to using Sindoxplatin 100mg Do not use Sindoxplatin for the following subjects without a doctor's prescription:
Patients who are hypersensitive or allergic to Oxaliplatin, similar drugs like Carboplatin (Paraplatin) , Cisplatin (Platinol) or other ingredients in the medicine. Sindoxplatin 100mg is contraindicated in pregnant or lactating women. Do not use Sindoxplatin 100mg drug for people with marrow failure, neutrophil count less than 2 x 109 / L or platelet count less than 100 x 109 / L. Sindoxplatin is contraindicated in patients with peripheral neuropathy. severe impairment of renal function (creatinine clearance < 30 ml/min).
3. Dosage and instructions for proper use of Sindoxplatin 100mg
3.1 Dosage of Sindoxplatin 100mg The drug Sindoxplatin lyophilized powder for solution for injection should be used in adults only at the recommended dosages below:
Additional treatment: Use approximately 85mg/m2 intravenously. , using the drug every 2 weeks, including 12 courses within 6 months. Treatment of metastatic colorectal cancer: The recommended dose is 85mg/m2 intravenously, used every 2 weeks. The dose of Sindoxplatin 100mg may be varied based on individual tolerability. It is best to consult your doctor for the best dose of Sindoxplatin.
3.2 Instructions for the correct and effective use of Sindoxplatin 100mg Sindoxplatin is usually given by intravenous infusion under the close supervision of a doctor. Patients may be given 5 fluorouracil (5 FU) prior to treatment with Oxaliplatin.
As recommended, Oxaliplatin will be infused intravenously over 2 to 6 hours with 5% Glucose solution in a volume ranging from 250 - 500ml to help achieve a concentration in the range of 0.2 - 0.7mg/ml . Oxaliplatin is often used in combination with a continuous infusion of 5 fluorouracil. Apply 5 fluorouracil drug regimens with bolus injection and continuous infusion with a course of treatment every 2 weeks.
4. Side effects when using Sindoxplatin 100mg
During intravenous infusion of Sindoxplatin, patients may inadvertently experience some of the following side effects from very common to rare:
Very common side effects: Anemia, infection, thrombocytopenia, neutropenia, lymphocytopenia, hyperglycemia, anorexia, hyponatremia, hypokalemia, sensory disturbances... Common side effects: Upper respiratory tract infection, inflammation nose, febrile neutropenia, neutropenic infection, depression, dehydration, motor neuritis, dizziness... Uncommon side effects: Hemolytic anemia, thrombocytopenia allergic immunity, temporary visual impairment, dysarthria, optic neuritis, pulmonary fibrosis, interstitial lung disease, deaf and mute. If you notice any unusual reactions in your body during treatment with Sindoxplatin, you should notify your doctor as soon as possible for appropriate treatment.
5. Important warnings when taking Sindoxplatin 100mg
5.1 What precautions should be taken when taking Sindoxplatin to ensure safety? Before deciding to treat with Sindoxplatin 100, the patient should tell the doctor if:
Are suffering from kidney disease, liver disease. Having heart disease or arrhythmia. Have a personal or family history of long QT syndrome. An imbalance of electrolytes, such as low levels of magnesium or potassium in the blood. Have high blood pressure, breathing problems, or have asthma. There are neurological problems. Are taking blood thinners, eg Warfarin. Due to the active ingredient Oxaliplatin has the risk of making patients more sensitive to cold, causing tingling, numbness or muscle spasms. This condition is more likely to occur when the patient is exposed to cold temperatures or objects with low temperatures. To prevent this phenomenon from happening, you can refer to and follow some steps below:
When exposed to cold air avoid breathing deeply. Cover areas such as the skin, head or face that are easily exposed to and affected by cold environments. Wear gloves when handling cold foods. Avoid iced or cold drinks. Sindoxplatin 100mg may cause nausea or mouth sores. Patients can talk to their doctor about other supportive treatments that can help relieve or improve these conditions. On the other hand, the active ingredient Oxaliplatin in Sindoxplatin also has the risk of reducing the number of blood cells that help the body fight infections and aid in blood clotting. Ideally, blood should be checked regularly during treatment with Sindoxplatin 100mg to detect and treat early if the above phenomenon occurs.
Taking Sindoxplatin during pregnancy can harm the unborn baby, so women who are pregnant should avoid taking this medicine. Sindoxplatin should also be used with caution in nursing women because there are no specific data on whether the drug is excreted in human milk.
The treatment with Sindoxplatin 100mg has a risk of causing nausea, vomiting, dizziness, dizziness or other neurological symptoms affecting the ability to maintain balance, gait and ability to use machines or patient's car.
5.2 Drugs that may interact with Sindoxplatin 100mg Several drugs have a risk of interacting with Sindoxplatin, including Salicylates, Erythromycin, Paclitaxel, Granisetron or Sodium valproate. In addition to the above drugs, some other drugs or substances have the potential to interact with Sindoxplatin 100mg that have not been mentioned. To minimize the possibility of drug interactions, you should tell your doctor about all the medicines you are currently taking, including herbs, multivitamins, health foods, etc.
Above are important information about Sindoxplatin 100mg, before using, patients should carefully read the instructions for use to get the best treatment results.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
