This is an automatically translated article.
Citicoline is also known as cytidine diphosphate-choline or cytidine 5-diphosphocholine, it is an intermediate in the production of phosphatidylcholine from choline and is also the main active ingredient in the drug Sekaf 500mg.1. What is Sekaf 500mg?
Sekaf 500mg is produced by Dat Vi Phu Pharmaceutical Co., Ltd with the main active ingredient is Citicolin 500mg. Therefore, Sekaf is used in the treatment of cerebrovascular disorders (including transient stroke), Parkinson's disease, and head trauma.
Sekaf 500mg is prepared in the form of film-coated tablets, each box includes 2 blisters (PVC-Aluminum) corresponding to each blister of 10 tablets.
2. Uses of the drug Sekaf 500mg
Sekaf 500mg is indicated for use in the treatment of the following diseases:
Cerebrovascular disorders (including ischemic attack or transient stroke); Parkinson ; Head trauma. Citicoline active ingredient, also known as Citidil-diphosphate Choline (CDPC), is a biological intermediate of lipid synthesis and a precursor for the synthesis of Lecithin (one of the important components of cell membranes). and organelles). Lecithin also plays a role in cell regeneration, so the use of Citicolin in Sekaf 500mg may provide some pharmacological effects on the central nervous system, including protection against many toxic substances (linked to CNS). related to tissue hypoxia, neurotoxic organic solvents, etc.).
Studies have found a correlation between brain damage and neurological dysfunction and phospholipid deficiencies in diseased brain regions. Phospholipid remodeling requires the incorporation of choline into phosphatidylcholine and must be done via CDPC.
Experimental data confirm that the use of Sekaf 500mg will assist in the treatment of neurological dysfunction in the elderly (including dizziness, migraine, fatigue, insomnia, memory impairment, etc.) , decreased fitness, postural disorders and social functioning), brain damage after surgery and after the presence of cerebral thrombosis.
Pharmacokinetic characteristics of Sekaf 500mg:
Absorption: Citicoline has a bioavailability of over 90%, soluble in water. In healthy adults, Citicoline is rapidly absorbed after oral administration, reaching peak plasma concentrations in two phases, including an initial phase at 1 hour after oral administration and a higher phase 2 reaching 24 hours after taking the drug; Metabolism and distribution: Sekaf 500mg is metabolised in the intestinal wall and liver. The hydrolysis of exogenous citicoline produces Choline and Cytidine. After absorption, these 2 substances are distributed throughout the body, enter the circulation to participate in many different biosynthetic pathways and can cross the blood-brain barrier to re-synthesize into Citicoline in the brain; Elimination: Studies using the 14C isotope show that Citicoline is eliminated mainly through respiration (CO2) and urine, going through 2 phases. The blood concentration of the active substance decreases sharply after reaching the peak concentration in phase 1, then decreases slowly over the next 4 - 10 hours. Similar is phase 2. The half-life of Sekaf 500mg by inhalation is 56 hours and urine is 71 hours.
3. Instructions for using the drug Sekaf 500mg
How to use: Sekaf 500mg drug is prepared for oral use.
Dosage: Usually 500mg citicoline per day, equivalent to 1 Sekaf 500mg tablet.
Overdosage of Sekaf and its management: There is no information on the manifestations or consequences of an overdose of Sekaf 500mg. However, the doctor should ask the patient to actively contact or go to a medical center if an overdose is suspected.
4. Undesirable effects of the drug Sekaf 500mg
When using Sekaf 500mg, patients are fully capable of experiencing unwanted effects (ADR):
Digestive disorders such as abdominal pain, diarrhea; Lower blood pressure; Fast heart rate or slow heart rate.
5. Contraindications of Sekaf 500mg
Do not use Sekaf drug for the following cases (contraindications):
Allergy to Citicoline or any ingredient of Sekaf 500mg; People with increased muscle tone of the parasympathetic nervous system; Women who are pregnant and breastfeeding.
6. Some precautions when using Sekaf 500mg
High doses of Citicolin can stimulate increased cerebral blood flow in cases of persistent intracranial hemorrhage; Sekaf 500mg is not recommended for children, so keep it out of reach of children; Sekaf medicine 500mg ingredients contain excipients Polysorbate 80, this is a substance with a risk of causing allergies. Besides, the castor oil in Sekaf can lead to nausea, vomiting, abdominal pain or diarrhea; Ability to drive and use machines: No information is available on the effects of Sekaf 500mg on the ability to drive or use machines; Pregnancy and breast-feeding: There is not enough reliable information about the safety of using the active ingredient Citicoline in Sekaf 500mg during pregnancy or breast-feeding. Therefore, the use of the drug is not recommended for these subjects.
7. Drug interactions of Sekaf 500mg
Do not use Sekaf 500mg concurrently with preparations containing Meclophenoxate or Centrofenoxine; Sekaf 500mg may increase the effectiveness of Levodopa, so caution should be exercised when combining these two drugs. Sekaf 500mg medicine has the main active ingredient is Citicolin 500mg. Sekaf is used in the treatment of cerebrovascular disorders (including transient stroke), Parkinson's disease, and head trauma. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to use prescription drugs or consult a doctor or pharmacist for advice.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
