Uses of Sametix

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Sametix contains the main active ingredient, Pantoprazole (as Pantoprazole Sodium Sesquihydrate), in the form of enteric coated tablets. Sametix helps to actively treat peptic ulcers, gastroesophageal reflux disease and Zollinger - Ellison syndrome.

1. What are the uses of Sametix?


Sametix contains the main active ingredient, Pantoprazole (in the form of Pantoprazole Sodium Sesquihydrate), which blocks gastric acid secretion by inhibiting the proton pump H + / K + ATPase at the secretory surface of gastric parietal cells, reducing acidity in the stomach, reducing symptoms such as heartburn, difficulty swallowing and persistent cough. In addition, Sametix also works to heal damage caused by acid in the stomach and esophagus, helping to prevent ulcers or esophageal cancer.

2. Indications of the drug Sametix


Sametix is ​​indicated for use in the following cases:
Benign progressive gastric ulcer; Benign progressive acute duodenal ulcer; GERD - Gastroesophageal reflux disease - oesophagitis; Patients with high gastrointestinal bleeding that are not caused by esophageal varices; Zollinger - Ellison syndrome ; Patients with duodenal ulcer with Helicobacter pylori infection (In combination with an appropriate course of antibiotics). Prevention of gastrointestinal ulcers when using non-steroidal anti-inflammatory drugs, corticosteroids. Do not use Rabsun in the following cases:
Patients with hypersensitivity or history of allergy to the ingredients of the drug Sametix; Patients with a history of anaphylaxis to Benzimidazole derivatives such as: Omeprazole, Esomeprazole, Lansoprazole.

3. Dosage and how to use Sametix


3.1. Dosage of Sametix Drugs Adults:
Gastroesophageal reflux disease (GERD): Usual dose: 20-40 mg/time x 1 time/day, used for 4 weeks, can be taken for a long time. up to 8 weeks. Then take maintenance dose: 20-40 mg/time x 1 time/day. In case of recurrent gastroesophageal reflux disease (GERD): Take 20mg/time x 1 time/day. Progressive gastric or duodenal ulcer: Usual dose: 40mg/time x 1 time/day. The duration of treatment lasts from 2-4 weeks for benign duodenal ulcers and from 4-8 weeks for benign gastric ulcers. Prevention of gastrointestinal ulcers caused by using non-steroidal anti-inflammatory drugs, corticosteroids: Take 20mg/time x 1 time/day. Zollinger - Ellison syndrome: Initial dose: Oral 80mg/day divided into 2 times. The maximum dose may be increased up to 240 mg/day. In case of H. pylori-positive benign gastric ulcer and/or duodenal ulcer: It is recommended to combine the following drugs within 7 days: Sametix 40mg twice daily + Clarithromycin 500mg twice daily and Amoxicillin 1g/time x 2 times/day or Metronidazol 400mg x 2 times/day. Other subjects:
Patients with liver failure: Maximum dose of Sametix: Take 20mg/time x 1 time/day, daily or use dose 40mg/day, taken every other day. Patients with renal failure: Maximum dose: 40mg/time x 1 time/day in the morning. 3.2. How to use the drug Sametix Sametix drug is produced in the form of enteric coated tablets with the content of each tablet 40mg Pantoprazole, taken orally. Before taking the medicine, the patient should carefully read the instructions for use on the drug leaflet. When swallowing the tablet whole with water, it is recommended to take it before breakfast or at night before going to bed for better therapeutic effect.

4. Undesirable effects of the drug Sametix


Common undesirable effects:
Systemic: Increased risk of infection. Nervous system: Fatigue, headache. On the skin: Red rash on the skin, urticaria. Musculoskeletal system: Muscle pain, joint pain. Uncommon side effects: Asthenia, dizziness, dizziness, pruritus, increased liver enzymes.
Rare adverse effects:
Body as a whole: Sweating, malaise, fatigue, peripheral edema, possible anaphylactic reactions. On the skin: maculopapular rash, acne, alopecia, exfoliative dermatitis, angioedema, erythema multiforme. Digestive system: Stomatitis, belching, digestive disorders. Eyes: Blurred vision, photophobia. Nervous system: Insomnia, somnolence, agitation or inhibition, tinnitus, tremor, confusion, hallucinations, paresthesias. Blood and lymphatic system: eosinophilia, agranulocytosis, leukopenia, thrombocytopenia. Urinary system - bio: Impotence, hematuria, interstitial nephritis. On the liver: Hepatitis, jaundice, encephalopathy in people with liver failure. Some tests: Hyponatremia, increased triglycerides.

5. Be careful when using Sametix


When using Sametix, the patient should pay attention to the following information:
It is necessary to exclude the possibility that the patient has gastrointestinal malignancy before treatment with Sametix because it may mask the disease symptoms. When taking Sametix drug for a long time (more than 1 year), the patient's health status should be monitored regularly. Sametix should be used with caution because it may cause cross-sensitization with other proton pump inhibitors or benzimidazole derivatives when used instead. Sametix should not be used in children because there are no studies on its use in children and it can cause side effects on the hematopoietic organs such as thrombocytopenia and neutropenia, which will decrease or disappear when stop medication. Sametix can cause an increase in liver enzymes during use, so it should be used with caution in people with severe liver impairment. Sametix, when used in high doses and for a long time (more than 1 year), may slightly increase the risk of hip, vertebral and wrist fractures, occurring mainly in the elderly or in subjects with high blood pressure. other risk factors. Patients at risk of osteoporosis should be consulted by a rheumatologist on how to prevent osteoporosis, supplement with calcium and vitamin D as indicated. There have been cases of electrolyte disturbances (severe hypomagnesemia) in patients treated with proton pump inhibitors, including Sametix, for at least 3 months, especially in subjects treated for more than 1 month. five. Symptoms of severe hypomagnesaemia may include: Fatigue, muscle spasms, delirium, convulsions, dizziness, and arrhythmias (ventricular arrhythmias), however the above symptoms may occur. occurs insidiously and can be missed. In the majority of patients with hypomagnesaemia, the patient's condition improved after magnesium supplementation and discontinuation of Sametix. Patients should have a magnesium level test before starting Sametix treatment and this index should be checked periodically in those patients who need long-term treatment (more than 1 year), or who need to take Sametix with them. Digoxin or other hypomagnesaemic drugs (eg diuretics). Treatment with proton pump inhibitors, including Sametix, may increase the risk of gastrointestinal infections with strains such as Salmonella, Campylobacter and Clostridium difficile. Patients should be excluded from gastrointestinal diseases and pseudomembranous colitis when using Sametix. Caution for pregnant women: There are no adequate and well-controlled studies of pantoprazole in pregnant women. Women who are pregnant should not take Sametix. Use Sametix only when prescribed by a doctor in cases where the benefits outweigh the risk factors. Note to nursing mothers: Because the drug can be excreted in breast milk and has the potential to cause adverse effects in the nursing infant from Sametix, a nursing mother should decide whether to discontinue the drug. or stop breastfeeding while using the drug. Notes when driving and operating machines: Due to the possible side effects of Sametix causing dizziness and visual disturbances affecting the patient's alertness, it is recommended that while taking Sametix do not drive or operate machinery. or when doing jobs that require alertness.

6. Sametix drug interactions


When using Sametix, the following drug interactions should be kept in mind:
Sametix may reduce the absorption of other drugs used concurrently whose absorption is pH dependent (eg, Ketoconazole). There is a potential for Sametix to interact with other drugs metabolised with the cytochrome P450 enzyme system such as carbamazepine, caffeine, diazepam, diclofenac, digoxin, ethanol, glibenclamide, metoprolol, nifedipine, phenprocoumon, warfarin, phenytoin, theophylline, and oral contraceptives Patients should minimize food or drink containing alcohol or stimulants while using Sametix. Because there may be unwanted drug interactions, so before using Sametix, patients need to inform about the drugs they are treating, the supporting tablets that they are using so that the doctor and pharmacist can understand. be informed and able to give appropriate and accurate advice to avoid drug interactions that are not beneficial to the patient.
Above is all information about Sametix drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Note, Sametix is ​​a prescription drug, patients need to use the drug as prescribed by the doctor, absolutely do not self-treat at home.

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