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Rolxexim 200mg drug has the active ingredient Cefpodoxime proxetil as the main active ingredient. This is a 3rd generation Cephalosporin antibiotic, effective in the treatment of upper respiratory tract infections, uncomplicated urinary tract infections,...
1. What is Rolxexim 200mg?
Rolxexim Capsule 200mg is a group of drugs for the treatment of parasites, anti-infectives, antivirals and antifungals with the main ingredient being Cefpodoxime proxetil.1.1. Pharmacodynamics of active ingredient Cefpodoxime is a 3rd generation Cephalosporin antibiotic with high stability against the attack of Beta-lactamases, produced by gram-negative and gram-positive bacteria.
1.2. Pharmacokinetics of the active substance Absorption: After oral administration, the active substance Cefpodoxime proxetil is rapidly absorbed and hydrolysed to Cefpodoxime. In intestinal epithelial cells, the ester group is released so that only the active substance Cefpodoxime enters the bloodstream. Following a therapeutic dose of 100 mg, mean peak plasma concentrations of 1.4 mcg/mL were reached in about 2 hours. When the drug is taken with food, the extent of absorption and mean peak plasma concentrations are increased; Area under the AUC curve increased by 33% in livestock. The bioavailability of the active substance Cefpodoxime is about 50%.
Distribution: Active substance Cefpodoxime proxetil is approximately 40% bound to plasma proteins.
Elimination ability : The active substance Cefpodoxime proxetil is eliminated unchanged by the kidneys and excreted by the kidneys. In vivo there is minimal metabolism of cefpodoxime. Approximately 33% of a therapeutic dose is excreted unchanged in the urine. The mean plasma half-life is about 2.8 hours.
1.3. Effect of active ingredient Cefpodoxime proxetil is active against Gram-positive and Gram-negative bacteria. The drug is stable for beta-lactamases.
2. The effect of the drug Rolxexim 200mg
Rolxexim 200mg is indicated for the treatment of the following infections:
Upper respiratory tract infections including sinusitis, tonsillitis, acute otitis media and pharyngitis. Acute pneumonia in the community. Acute gonococcal infection without associated complications. Urinary tract infection without associated complications. Bacterial infections of the skin and the structure of the skin.
3. Usage and dosage of Rolxexim 200mg
Treatment dose for adults:
Treatment of upper respiratory tract infections, including tonsillitis and pharyngitis: 100mg every 12 hours for 10 days. Treatment of acute community-acquired pneumonia: 200 mg every 12 hours for 14 days. Treatment of uncomplicated acute gonococcal infection: a single dose of 200 mg. Treatment of uncomplicated urinary tract infections: 100 mg every 12 hours for 7 days. Treatment of skin and skin structure infections: 400 mg every 12 hours for 7-14 days. Treatment dose for children:
Treatment of acute otitis media: 10 mg/kg/day (maximum 400 mg/day divided into 2 divided doses) for 10 days. Treatment of pharyngitis and tonsillitis: dose 10 mg/kg/day (maximum 200 mg/day divided into 2 times) for 10 days. Active ingredient Cefpodoxime should be administered with food. In subjects with renal impairment (creatinine clearance less than 30 ml/min), the dosing interval should be increased to 24 hours. No dose adjustment is required in people with cirrhosis. Prescription drugs require a prescription from a treating doctor or pharmacist. Over-the-counter medicines require a leaflet from the manufacturer. Patients need to actively read and follow the exact dose indicated on the prescription or drug instruction sheet.
4. In case of over/forgotten dose
When taking an overdose of Rolxexim 200mg, the patient should stop taking it and immediately notify the treating doctor or pharmacist when there are abnormal symptoms. At the same time, it is necessary to bring the overdose person to medical facilities immediately for timely treatment. When traveling, family members should bring medical records, all prescriptions or medicine bottles that have been and are being used so that doctors can quickly diagnose and treat
When forgetting a dose: Usually medicines can be taken orally. 1-2 hours longer than prescribed in the prescription. However, if the time is too far from the time you need to drink, you should not make up for it, because it can be dangerous to the body.
5. Undesirable effects of the drug Rolxexim 200mg
Side effects of Rolxexim 200mg that have been reported in clinical trials are usually mild and transient, including: diarrhea, nausea, vomiting, abdominal pain, colitis and headache.
Side effects rarely occur hypersensitivity reactions, rash, pruritus, dizziness, thrombocytopenia, thrombocytopenia, leukopenia or eosinophilia.
6. Interactions of Rolxexim 200mg
Plasma concentrations are reduced by approximately 30% when the active ingredient cefpodoxime is administered with an antacid or an H2 blocker When Rolxexim 200 mg is prescribed concomitantly with a known nephrotoxic compound, monitoring is recommended. monitor kidney function. Cefpodoxime plasma concentrations are increased when this drug is administered with probenecid. Changes in laboratory parameters: The active substance Cephalosporin causes the direct Coomb test to be positive. You should note that drug interactions with other drugs are often quite complicated due to the influence of many ingredients in the drug. Studies or recommendations usually only show the types of interactions that are common with drug use.
You also need to consider taking Rolxexim 200mg with alcohol, tobacco, alcoholic or fermented beverages. These agents can change the effectiveness of the medication.
7. Some notes when using Rolxexim 200mg
7.1. Contraindications of the drug People with a history of hypersensitivity to the active substance Cefpodoxime proxetil or the cephalosporin group of antibiotics. People who are suffering from porphyria. Contraindications of the drug Rolxexim 200mg must be understood as absolute contraindications, ie not for any reason that contraindicated cases are flexible enough to use the drug.
7.2. Notes and cautions when using Rolxexim The subjects that need to be noted before taking Rolxexim: the elderly, pregnant women, lactating women, children under 15 years old, people with liver failure, kidney failure, people who are allergic to any substance in the drug's ingredients... Or people with myasthenia gravis, hepatic coma, stomach ulcers. As with other cephalosporins, Rolxexim 200 mg should be used with caution in people receiving concomitant treatment with potent diuretics. 7.3. Precautions during pregnancy Using drugs with pregnant women: You need to consider and consult your doctor or pharmacist before taking the medicine. Drugs that have been thoroughly tested still have risks when used. Using the drug with breastfeeding women: Mothers need to carefully weigh the benefits and risks for mother and baby. You should not arbitrarily use the drug without carefully reading the instructions for use and instructions of the treating doctor to protect both mother and baby. 7.4. How to store the medicine Store the medicine at a temperature below 25 degrees Celsius, avoid direct exposure to sunlight or high temperature, it can convert the ingredients in the drug. Carefully read the instructions for storing the drug on the package and the instruction sheet for Rolxexim 200mg. Carefully check the expiry date before treating with the medicine. When not using Rolxexim 200mg, it is necessary to collect and handle according to the instructions of the manufacturer or the person in charge of medicine. Rolxexim medicine 200mg has the active ingredient Cefpodoxime proxetil as the active ingredient. This is a 3rd generation Cephalosporin antibiotic, effective in the treatment of upper respiratory tract infections, uncomplicated urinary tract infections,... To ensure effective treatment and avoid side effects, people The patient should take the medicine according to the instructions of the doctor or pharmacist.
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