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The active ingredient Rogyllaf is Acetyl Spiramycin with the strength of 100mg and Metronidazol with the strength of 125mg. This is an antibiotic that is effective in the treatment of diseases caused by parasites, antifungal, anti-bacterial and anti-viral.
1. What is Rogyllaf?
What is Rogyllaf? Rogyllaf drug has the main active ingredient Acetyl Spiramycin with the strength of 100mg and Metronidazol with the strength of 125mg. This is an antibiotic that is effective in the treatment of diseases caused by parasites, antifungal, anti-bacterial and anti-viral.
Rogyllaf is prepared in the form of film-coated tablets, suitable for direct oral use. Packing is a medicine box with 2 blisters and each blister contains 10 tablets.
Effects of ingredients in Rogyllaf:
Active ingredient Acetyl Spiramycin: is a monoacetate derivative of Spiramycin. Spiramycin is a macrolide antibiotic with an antibacterial spectrum similar to that of erythromycin and clindamycin. This antibiotic has a bacteriostatic effect on bacteria during the stage of cell division. At serum concentrations, Acetyl Spiramycin is bacteriostatic, but when reaching tissue concentrations it can be bactericidal. The mechanism of action of this active ingredient is to act on the 50S subunit of the bacterial ribosome and prevent the bacteria from synthesizing proteins. Active ingredient Metronidazole: Is a 5-nitro-imidazole derivative, with a broad spectrum of activity on protozoa such as Amoeba, Giardia and anaerobic bacteria. The antibiotic Metronidazole has good effects on both intra- and extra-intestinal amoeba, both acute and chronic. With chronic intestinal amoebic dysentery, the drug has a weaker effect due to less penetration into the colon. The drug also works well with Trichomonas vaginalis, Giardia, gram-negative anaerobes including Bacteroides, Clostridium, Helicobacter but has no effect on aerobic bacteria.
2. What diseases does Rogyllaf treat?
Rogyllaf is a medicine prescribed by a treating doctor used in:
Treatment of acute, chronic or recurrent oral diseases, especially gingivitis, tooth abscess, inflammation around the jawbone, gingivitis, periodontitis, gingivitis, stomatitis... Prophylactic treatment of the risk of dental infection after surgery.
3. Usage and dosage of the drug Rogyllaf
3.1. How to take Rogyllaf Rogyllaf is made in the form of film-coated tablets, suitable for oral administration. Patients should use the drug according to the doctor's recommendations, do not change the dose arbitrarily to avoid unwanted effects on health.
3.2. Therapeutic dose of the drug Rogyllaf The specific dosage of the drug is as follows:
For adults: Take 4-6 tablets/day, divided 2-3 times, taken with meals. In case, it is possible to use a loading dose of 8 tablets/day. For children from 10 to 15 years old: Take 3 tablets/day. For children from 6 to 10 years old: Take 2 tablets/day. It should be noted: Dosage as described above is for reference only and cannot replace the prescription of a medical doctor. To have a specific dose and suitable for your health condition, you need to consult with the doctor treating the disease.
4. Undesirable effects of the drug Rogyllaf
4.1. Undesirable effects for the active ingredient Acetylspiramycin Rarely, serious adverse effects on the health of users of the drug are encountered. Common undesirable effects on the digestive system such as nausea, vomiting, diarrhea, dyspepsia.
Uncommon side effects:
Feeling tired, nosebleeds, sweating, chest tightness. Short-term paresthesia of a transient nature, dysesthesia, grogginess, pain, stiffness in muscles and joints, burning sensation. Acute colitis, appearance of skin rash, exanthema, urticaria on the skin. Other rare adverse effects such as anaphylaxis, superinfection caused by long-term use of the drug.
4.2. Undesirable effects of the active ingredient Metronidazol When using the drug with high therapeutic doses and for a long time increases unwanted effects, namely mild gastrointestinal disorders: nausea, anorexia, Metallic taste in mouth, epigastric pain, vomiting, diarrhea.
In some exceptional cases, other undesirable effects may occur such as:
Skin or mucosal reactions: urticaria, vasomotor flushes, pruritus, glossitis with a feeling of dry mouth ; Neurological and psychiatric signs: headache, dizziness, dizziness, confusion, convulsions; Pancreatitis, reversible upon discontinuation of treatment with this drug. Decrease in white blood cell count. Peripheral sensory neuropathy, these symptoms decrease and then completely disappear when treatment is stopped. Other rare but still possible side effects include agranulocytosis, seizures, peripheral polyneuropathy, skin blistering, skin rash, and pruritus.
Urine may be stained reddish brown due to pigments formed by the metabolism of Rogyllaf.
In addition to the above side effects, if the patient experiences any other unwanted side effects while using Rogyllaf, it is necessary to immediately notify the doctor for advice and timely treatment.
5. Rogyllaf drug interactions
Interactions of Rogyllaf drugs may occur during use as follows:
Active ingredient Metronidazol increases the effect of anticoagulants, especially Warfarin, so avoid using Rogyllaf at the same time as anticoagulants. Metronidazole has a disulfiram-like effect. Therefore, Rogyllaf should not be used concurrently with these drugs to avoid toxic effects on the nervous system such as psychosis, confusion. Concomitant use of Metronidazole and Phenobarbital increases the metabolism of Metronidazole, so Metronidazole is eliminated faster.
6. Some notes when using the drug Rogyllaf
In the process of using Rogyllaf, patients should pay attention to the following issues:
6.1. Contraindications of the drug Rogyllaf is contraindicated to use Rogyllaf in the following cases:
Contraindicated to use the drug in people who are sensitive or have hypersensitivity to one of the ingredients of the drug. Do not use the drug with children under 6 years old. Do not use Rogyllaf with pregnant or nursing women. The active ingredient Metronidazole in the composition of the drug is contraindicated for use in people with epilepsy or those with blood clotting disorders. 6.2. Precautions when taking Rogyllaf Drugs Caution when using Rogyllaf in the following cases:
Active ingredient Acetylspiramycin is in the composition of the drug, so it should be used with caution in people with liver dysfunction. The reason is that this active ingredient can cause liver toxicity. Metronidazol active ingredient: Metronidazol has an inhibitory effect on alcohol dehydrogenase and other alcohol oxidizing enzymes. Rogyllaf has been associated with mild disulfiram-like reactions such as flushing, headache, nausea, vomiting, abdominal cramps, and sweating. Metronidazole can induce immobilization of Treponema pallidum, resulting in a false-positive response to the Nelson test. Use in pregnant and lactating women: Not used. Using the drug while driving and handling machines: Rogyllaf does not cause drowsiness, does not affect the activity of people when driving or operating machinery. Therefore, you can use the drug to treat the disease without affecting your work. Above is all information about Rogyllaf drug, patients need to carefully read the instructions for use, consult a doctor / pharmacist before using. Absolutely do not arbitrarily buy Rogyllaf to treat the disease at home, because there may be unwanted side effects on health.
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