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Remebentin 100 mg drug has the main active ingredient Ghabapentin 100mg and other excipients in a sufficient amount. This medication is used to treat pain caused by neurological diseases and epilepsy.
1. What is Remebentin 100?
Drug group: Remebentin 100 belongs to the group of psychotropic drugs Dosage form: Capsules Packing: The medicine box includes 5 blisters x 10 tablets The main ingredient is Gabapentin drug. 1.1. Pharmacokinetics of Remebentin 100mg Gabapentin is structurally related to the neurotransmitter gamma - aminobutyric acid (GABA) but its mechanism of action is different from many drugs that interact with GABA synapses. The characterization and function of gabapentin binding sites remain to be elucidated and the appropriateness of its various effects for the treatment of epilepsy must be determined.
Analgesic activity has been demonstrated in animal inflammatory and neuropathic pain experiments. Therapeutic efficacy has not been established in children under 6 years of age.
1.2. Pharmacokinetics of Remebentin 100 mg The bioavailability of the drug Gabapentin is not proportional to the therapeutic dose. This means that as the therapeutic dose is increased, its bioavailability decreases. After oral administration, peak plasma concentrations of gabapentin are reached within 2 to 3 hours. The absolute bioavailability of Remebentin 100 mg capsules is approximately 60%. Food, including high-fat diets, had no effect on the pharmacokinetics of gabapentin. The elimination of gabapentin from plasma is best described by the pharmacokinetic properties represented by the curve. The plasma half-life of gabapentin is independent of the therapeutic dose and ranges from 5 to 7 hours on average. Gabapentin is eliminated from plasma by hemodialysis. Therefore, dose adjustment is required in patients with impaired renal function or on dialysis. Gabapentin plasma concentrations in children are similar to those in adults.
2. What are the effects of Remebentin 100mg?
Remebentin 100mg is indicated for use in the following cases:
Treatment of epilepsy:
Gabapentin is indicated as monotherapy in the treatment of partial seizures with or without generalization. secondary form in adults and children over 12 years of age. The safety and efficacy of a single-dose regimen of gabapentin in children under 12 years of age have not been established. Gabapentin is indicated as adjunctive treatment in the treatment of partial seizures with or without secondary generalization in adults and children 3 years of age and older. The safety and effectiveness of gabapentin adjuvant therapy in children under 3 years of age have not been established. Treatment of neuropathic pain:
Gabapentin is indicated for the treatment of neuropathic pain in adults 18 years of age and older. The safety and effectiveness of gabapentin in children under 18 years of age have not been established.
3. Usage and dosage of Remebentin 100mg
How to use the drug: Remebentin 100mg is made in the form of capsules suitable for oral drug use.
Treatment dose: According to the instructions of the treating doctor.
Treatment of neuropathic pain:
Adults over 18 years: For the treatment of neuropathic pain, the dose should be increased gradually up to a maximum dose of 1800 mg daily with an initial dose of 300 mg daily. Elderly: The elderly may require dose therapy because of age-related decline in renal function. Treatment of epilepsy:
For children over 12 years old and adults: for the treatment of epilepsy, the usual therapeutic dose is 900 - 1200 mg/day. Start at 300mg and gradually increase to the effective dose. The maximum therapeutic dose is 2400 mg a day in divided doses. Children 6 - 12 years: The recommended dose is 25-35 mg/kg/day in divided doses (3 times a day). Elderly: The elderly may require dose therapy because of age-related decline in renal function. For people with renal failure or people on dialysis: A loading dose of 300-400 mg should be used, then 200-300 mg after 4 hours of dialysis. Note: The above therapeutic dose is for reference only as recommended by the manufacturer. The specific treatment dose depends on the health status and progress of the disease of each specific person. For the right therapeutic dose, you need to consult your treating doctor or medical professional.
4. In case of overdose/missing dose of Remebentin 100mg
In case you or suspect that someone else is taking a higher than normal dose of Remebentin 100mg, you should inform your doctor immediately. Signs and symptoms of overdose may include dizziness, lightheadedness, double vision, slurred speech, feeling drowsy, sluggishness, and mild diarrhea. The user can make a full recovery with supportive treatment. Although Gabapentin can be eliminated by hemodialysis, this is not necessary. However, for people with kidney failure, a doctor may prescribe dialysis.
In case of missed dose: If you have to take Remebentin 100mg continuously and miss a dose, take it again as soon as possible. However, if it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. You should absolutely not take a double dose. In case you forget more than one dose, consult your doctor.
5. Undesirable effects when treated with Remebentin 100
The side effects encountered when using Remebentin 100mg in the treatment of epilepsy:
The reason is that Remebentin 100mg is mostly used in combination with other antiepileptic drugs, so it cannot be determined exactly. exactly which drug, if any, is associated with undesirable effects.
Other side effects encountered during clinical treatment with the drug:
In combination therapy:
Whole body: Weakness, weakness or facial edema. Cardiovascular system: Hypertension. Digestive system: Flatulence, gingivitis or loss of appetite. Blood and lymphatic system: A skin rash on the skin is often described as bruises experienced with trauma. Musculoskeletal system: Pain in joints. Nervous system: Dizziness, hyperactivity, increase or decrease or loss of reflexes, paresthesia and anxiety disorders. Respiratory system: Pneumonia. Genitourinary system: urinary tract infections may occur. Special Senses: Abnormalities in vision such as vision disturbances. When used as monotherapy:
When used as monotherapy: The most common undesirable effects associated with discontinuation of the drug are nervousness, weight gain, fatigue, dizziness, nausea or vomiting vomiting and somnolence. For use in patients with impaired renal function, the dose should be adjusted. Use in Children: The most common adverse effects of gabapentin in combination with other antiepileptic drugs in children 3 to 12 years of age may include nausea and/or vomiting and sleepiness. chicken. Uncommon side effects such as: upper respiratory tract infection, pharyngitis, otitis media, cough, headache, rhinitis, convulsions, diarrhea, loss of appetite. Discontinuation due to adverse effects: The most common adverse events leading to discontinuation of Gabapentin treatment included: somnolence, ataxia, dizziness, fatigue, nausea and/or vomiting. Almost all people who take the drug experience multiple side effects and it is not possible to distinguish which side is predominant. When using Remebentin in children: Side effects commonly associated with discontinuation in children are somnolence, hyperactivity.
6. Remebentin 100 . drug interactions
There are many drugs that interact with Remebentin 100mg and should not be used at the same time. However, some drugs can be used concurrently under special caution. In this case, the treating physician may change the dose and take other precautions if necessary. It is important that you tell your doctor what medicines you are taking, especially the following: antacids containing aluminum and magnesium or morphine.
Other possible interactions: False positive for protein in urine absorption - metabolism - elimination tests, N - Multistix, SG8 dipstick when Remebentin 100mg is used in combination with antiretroviral drugs other convulsions.
7. Some notes when using Remebentin 100
Before using Remebentin 100mg you need to carefully read the instructions for use and refer to the information below.
7.1. Contraindications of the drug Remebentin 100mg Remebentin 100 is contraindicated in the following cases:
Local hypersensitivity or hypersensitivity to the active substance or any component of the drug. Remebentin should not be used in children under 6 years of age. 7.2. Precautions while using Remebentin 100mg If you have an intolerance to certain sugars, tell your doctor right away before taking this medicine. Although there is no evidence of rebound seizures with Remebentin, abrupt discontinuation of antiepileptic drugs in epileptic patients may induce seizures. Any dose reduction, discontinuation, or change in antiepileptic drugs should be done gradually over a period of at least one week, under the direction of the treating physician. Remebentin is not generally considered effective in the treatment of absence seizures. When using the drug Remebentin can suffer from mood and personality disorders. Particular caution should be exercised in persons with a history of psychotic episodes and those on dialysis. Ability to drive and use machines: Gabapentin may cause central nervous system effects and may cause drowsiness, dizziness, headache or other related symptoms. Although these effects are relatively mild, they affect the ability to drive and use machines. For this reason, you should avoid driving and operating machinery at least until the effect of the drug on your health has been determined. Pregnancy: Do not use Remebentin 100mg during pregnancy. You should consult your doctor before taking any medication. Lactation: Gabapentin is excreted in breast milk, so it should not be used in nursing women. Remebentin medicine 100 mg has the main active ingredient Ghabapentin 100mg and other excipients in a sufficient amount. This medication is used to treat pain caused by neurological diseases and epilepsy. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as prescribed by a doctor, professional pharmacist.
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