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Refix 550 is a treatment for problems such as diarrhea caused by E.Coli bacteria or irritable bowel syndrome in adults. In order to achieve optimal results in treatment, patients need to follow the doctor's instructions and take the medicine according to the prescribed dose.
1. What is Refix 550?
Refix 550 mg is a drug used primarily to treat irritable bowel syndrome conditions and diarrhea in adults, and to help reduce the rate of recurrence of hepatic encephalopathy in patients 18 years of age and older. up. Refix 550mg is a pharmaceutical product of Atra Pharmaceuticals Limited (India), officially distributed in Vietnam market by Vimedimex Pharmaceutical Joint Stock Company.
Refix 550 mg is prepared in the form of film-coated tablets, oblong, orange tablets and packed in boxes of 3 blisters x 10 tablets. In each Refix 550mg tablet contains the following ingredients:
Main ingredients: Rifaximin antibiotic with the corresponding content of 550mg. Other active ingredients just enough for one tablet: Talc powder, vitamin C, polyvinylpyrrolidone K-30, cellulose, magnesium stearate.
2. Indications and uses of Refix 550mg
Refix 550mg is a prescription medicine for patients over 18 years old and is usually indicated for use in the following cases:
Treatment of symptoms such as behavioral changes, changes in thinking and personality due to causes toxin accumulation in the brain in people with liver disease; Prevent the risk of recurrence of hepatic encephalopathy; Treatment of diarrhea caused by E coli bacteria ; Treat and improve symptoms of irritable bowel syndrome; Treatment of infectious diarrhea, appendicitis or bacterial overgrowth in the intestinal tract; Prophylaxis of infectious complications for patients before and after intestinal surgery.
3. Uses of Refix 550mg
*Pharmacodynamics
The component rifaximin in the drug Refix 550 mg acts as an antibiotic (of the Rifamycin group) with local action and action based on the mechanism of irreversible binding to platelets The beta taste of RNA polymerase depends on bacterial DNA. This leads to inhibition of bacterial RNA synthesis.
On the other hand, the antibiotic Rifaximin has a broad antibacterial spectrum, which helps against the majority of gram (+), gram (-), anaerobic, aerobic and ammonia-producing bacteria that cause intestinal infections. Rifaximin has the ability to inhibit the division of urea-reducing bacteria, thereby reducing the production of ammonia and some other compounds closely related to the pathogenesis of hepatic encephalopathy.
*Pharmacokinetics
The following is the pharmacokinetics of Refix 550mg:
Absorption: After oral administration, the active ingredient Rifaximin is poorly absorbed (less than 1%) in the α polymorphic form. . An increase in systemic absorption of rifaximin was observed when administered within 30 minutes after a high-fat breakfast. Distribution: Rifaximin is moderately bound to plasma proteins. According to the test, the protein binding rate of Rifaximin on average reached 67.5% (in healthy subjects) and 62% in subjects with liver failure. Elimination: Studies show that 14 C-rifaximin is eliminated almost completely in the feces (accounting for 96.0% of the dose of Refix 550). Meanwhile, 14 C-rifaximin had a urinary recovery rate not exceeding 0.4% of the dose.
4. Contraindications to using Refix 550mg
The following are cases where Refix 550 mg should not be used, including:
People who are allergic to Rifaximin or are hypersensitive to any of the excipients in the drug; People with liver disease or a previous history of liver disease; People with diarrhea caused by taking another antibiotic; People with bloody diarrhea or high fever; People with diarrhea not caused by strains of E. Coli bacteria; Women who plan to become pregnant, are pregnant or are breastfeeding; Patients who are on medication or other therapies need to talk to their doctor before using Refix 550mg.
5. Dosage and how to use Refix 550 mg
Dosage of Refix 550 will be determined based on the specific medical condition and age of the patient. Below is information on the dosage of Refix 550mg that is generally recommended by doctors:
Treatment dose for patients with diarrhea caused by E.Coli bacteria: Take 550mg / time, up to 3 times / day. The interval between doses is usually 8 hours and treatment should be within 3 days. Dosage for people with irritable bowel syndrome: Take 1 tablet / time, up to 3 times / day with a treatment period of 14 days. Prophylactic dose of hepatic encephalopathy: Take 1 tablet / time, up to 2 times / day. The time between doses is usually 12 hours. The duration of treatment for patients with hepatic encephalopathy will depend on the doctor's prescription. Before using Refix 550, patients should carefully read the manufacturer's instructions for use or consult a doctor to get the most appropriate dose. Dosage as well as the course of treatment with Refix 550mg will depend on the patient's health condition.
Because Refix 550mg is made in the form of tablets, so you can use it orally before or after eating. When taking the drug, avoid biting, chewing or crushing the tablet as this will destroy the drug structure and lead to reduced effectiveness.
You should take the medicine with a full glass of water, only use cooled boiled water or filtered water. Absolutely do not take refix 550 with soft drinks, stimulants or carbonated water. In addition, the drug should be used according to the schedule, avoiding arbitrarily stopping or increasing / decreasing the drug dose without approval from the prescribing doctor.
6. How to handle when taking an overdose or forgetting a dose of Refix 550 mg *In case of taking an overdose of Refix 550mg
If taking an overdose of Refix 550 compared to the prescribed dose and symptoms such as shortness of breath or unconscious, the patient needs immediate medical attention. The patient's family needs to bring the medicine and prescription that the patient has taken, and inform the doctor about the patient's weight and height.
*In case of forgetting a dose of Refix 550 mg
Replenish the missed dose immediately within 1-2 hours. However, if it is too close to taking the next dose, you should skip the missed dose and take the medicine at the prescribed time, avoid double-dose.
7. Some side effects when using Refix 550mg During treatment with Refix 550, patients may experience some of the following side effects or adverse reactions (ADRs):
*Effects common side effects:
Digestive problems, such as diarrhea, nausea, vomiting, upper abdominal pain or bloating; nerve problems such as headache, depression, dizziness, drowsiness or insomnia; Certain skin or subcutaneous tissue disorders such as rash, itching; Arthralgia, peripheral edema and muscle spasms. *Uncommon side effects:
Hemorrhagic esophageal varices, abdominal pain, dry mouth or stomach discomfort; Memory loss, balance disorder, attention disorder, convulsions, memory impairment or decreased sensation; Falls, edema, fever, urinary frequency or difficulty urinating. *Rare side effects:
Subcutaneous connective tissue inflammation, pneumonia, rhinitis or upper respiratory tract infection; Constipation, dehydration, low/high blood pressure; Proteinuria. In case any of the side effects mentioned above appear, the patient should stop taking Refix 550 and immediately notify the doctor for the right treatment.
8. Some notes when using and storing Refix 550mg Here are some things that patients need to be careful about when treated with Refix 550:
Do not use Rifaximin concurrently with other Rifamycins; Refix 550mg can lead to urine discoloration (reddish color) during use; Use caution when administering Refix 550 in patients with severe hepatic impairment or with a MELD score > 25; Use caution when using Refix 550 for pregnant women, breastfeeding mothers or adolescents under 18 years of age; Caution should be exercised when rifaximin is administered concomitantly with a P-glycoprotein (eg, ciclosporin). Drug Refix 550 mg may have an interaction reaction when used with some of the following drugs:
Warfarin drug may affect the effect of Refix drug when used in combination. In case of need, the patient can adjust the dose of anticoagulants accordingly and take the dose of Refix exactly as prescribed by the doctor. When a single dose of Rifaximin 550mg is used together with a single dose of Ciclosporin 600mg, the mean Cmax of the active ingredient Rifaximin can be increased 83-fold. Avoid taking Refix 550 together with Rifabutin or Rifampin as this may decrease its effectiveness. Do not take Refix while taking hormonal contraceptives because fullness can lead to an unwanted pregnancy. Drug interactions can occur when refix is taken with tobacco, alcohol, beer, and other stimulants. In order to avoid drug interactions, patients should inform their doctor of all medications they are taking, including prescription/nonprescription drugs, vitamins, supplements, dietary supplements, and herbs. ,...
Each drug will have different storage and preservation methods. To have a reasonable way to store Refix 550 mg, you need to carefully refer to the instructions of the manufacturer, doctor or apply the following general storage:
Store Refix 550 at room temperature, ideally 20 – 25 degrees Celsius, avoid direct light; Avoid storing medicine in areas with high humidity, such as bathrooms; Keep the medicine in a dry place, limit access to children and pets; Dispose of expired or damaged drugs at the prescribed place; Do not give medicine to others even though they know they are suffering from the same symptoms.
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