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Reblozyl drug belongs to the group of drugs related to blood diseases with the main ingredient including Luspatercept 25mg, which is made in the form of an infusion solution. The drug is indicated in the treatment of beta thalassemia requiring frequent red blood cell transfusions, which help red blood cells mature. Therefore, before using Reblozyl, patients should carefully learn about the drug and follow the doctor's instructions.
1. Mechanism of action of the drug Reblozyl
Reblozyl drug is prepared in the form of a solution containing 25mg of Luspatercept and a sufficient number of excipients. Luspaterceots bind to the TGF-beta protein which suppresses and attenuates the abnormal signal transduction of Smas 2⁄3 and promotes erythrocyte growth at the final stage in erythropoiesis.
2. Indications and contraindications of the drug Reblozyl
Reblozyl is used in the growth correction of terminal red blood cells to help patients reduce the burden of RBC transfusion. In addition, Reblozyl is also indicated in the treatment of anemia in adult patients with beta thalassemia who need regular red blood cell transfusions.
However, when using Reblozyl, patients should evaluate the hemoglobin results before deciding to use the drug.
Reblozyl drug is contraindicated for some cases of hypersensitivity to the drug's ingredients, or patients who are allergic to the active ingredient of Reblozyl.
3. Dosage and how to use Reblozyl
Reblozyl drug is used in treatment with dosage depending on the patient's weight, health, and age. Dosage of Reblozyl is prescribed according to the instructions of the doctor.
The recommended dose of Reblozyl for patients is in the form of subcutaneous injection at a dose of 1mg/kg body weight every 3 weeks.
Reblozyl is administered subcutaneously and must be administered by medical personnel. When using Reblozyl, patients should be monitored for blood pressure, if blood pressure suddenly increases, medical assistance can be timely.
4. Unwanted side effects and some notes when using Reblozyl
Reblozyl can cause some unwanted side effects and the degree of dependence depends on the specific case.
Muscle and joint pain. Reblozyl may cause moderate to severe musculoskeletal pain. This can happen for about 1 day or a few months after using Reblozyl. When experiencing these signs, the patient should notify the treating doctor to have a plan to relieve the pain. The patient is always tired. After cancer treatment, patients always feel exhausted. Therefore, patients need to adjust as well as plan long-term rest and save energy for important activities. In addition, patients can do exercise to combat fatigue by walking, relaxing... Diarrhea may occur in cancer cases. Therefore, your doctor may prescribe some medications to help relieve diarrhea. In addition, patients should eat foods low in fiber, and limit eating raw foods that can affect health. Hepatotoxicity can occur with cancer causing hepatotoxicity. Patients should be monitored through liver function tests. Therefore, if the patient experiences signs of yellow skin and eyes, dark urine can be a sign of liver toxicity and should immediately notify the treating doctor for support. Blood clots cause heart attacks and strokes. Reblozyl may increase the risk of blood clots, leading to an increased risk of heart attack and stroke. If the patient experiences this problem, it should be reported to the doctor immediately. The telltale signs can include redness, swelling, pain in one or both hands, pale skin, severe chest pressure, back pain, difficulty breathing, difficulty speaking, confusion, and possibly even changes. mental status change. High blood pressure can occur with the use of Reblozyl. Therefore, patients should have their blood pressure checked regularly during treatment with Reblozyl. If the patient cannot control the high blood pressure, the drug should be stopped and reported to the doctor for support. Reblozyl can cause birth defects in an unborn baby. Therefore, those who are pregnant or planning to become pregnant should consider carefully when using the drug if necessary. In short, Reblozyl is only used as directed by your doctor. Adhering to the correct dosage and administration will help the treatment process to be more effective.
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Reference source: oncolink.org
