This is an automatically translated article.
Realdiron Tab is a prescription drug prescribed by doctors for patients after stroke, myocardial infarction and peripheral artery disease. To use Realdiron Tab safely and effectively, users need to follow the instructions of their doctor, refer to the information content in the following article.
1. Uses of Realdiron Tab
1.1. What is Realdiron Tab? Realdiron Tab is a cardiovascular drug with the ingredient Clopidogrel (as Clopidogrel bisulfate) 75mg. Medicines manufactured by Young Poong Pharm Co., Ltd circulate in Vietnam and are registered with the registration number VN-20761-17.
Realdiron Tab contains the following ingredients:
Clopidogrel Bisulphate 75mg. Excipients (Lactose Hydrate, Colloidal Silicon Dioxide, Copovidone, Low substituted hydroxypropyl cellulose, Talc, Magnesium Stearate, Hypromellose 2910, Polyethylene Glycol 6000, Polysorbate 80, Castor oil, Talc, Iron oxide red, Carnauba wax, Titanium Dioxide.) Dosage form: Film coated tablets.
1.2. What does Realdiron Tab do? Realdiron Tab is used to reduce the risk of cardiovascular disease or cerebrovascular diseases (myocardial infarction, stroke and cerebrovascular accident) in patients with atherosclerosis manifested by ischemic stroke. , recent myocardial infarction or peripheral artery disease/
Realdiron Tab is also used to reduce the risk of cardiovascular disease in patients with unstable angina or non-ST-segment elevation myocardial infarction. non-Q wave), including healthy treated patients and patients who have undergone subcutaneous coronary intervention with or without busbars or coronary artery bypass grafting.
Control and prevent risk of recurrence in atherosclerotic patients with recent stroke, myocardial infarction, or established peripheral arterial disease.
2. How to use Realdiron Tab
How to take Realdiron Tab:
Clopidogrel is taken orally, regardless of meals. The drug is used as directed by the doctor. Dosage of the drug Realdiron Tab:
Doses are calculated according to clopidogrel, taking into account the genetic pharmacology in poor metabolisers. The daily oral dose in adults is 75 mg/day. After myocardial infarction, stroke, peripheral artery disease: 75mg/day, taken once. A , then 75mg/day (in combination with 75-325mg Aspirin/day). If the patient cannot take aspirin, a first dose of clopidogrel 300-600 mg should be given at least 24 hours before the intervention, then 75 mg/day for at least 12 months. Myocardial infarction with ST elevation:
If the patient is on conservative therapy, take clopidogrel 75mg/day (in combination with aspirin 75mg-162mg/day). Duration of treatment < 28 days, usually until hospital discharge. A first dose of 300-600 mg/day can be used if the patient has an indication for coronary intervention. After coronary intervention, the patient continued to take 75mg/day for at least 12 months. Pediatric dosing:
Optimal pediatric dose information is not available. Information on pediatric dosing is very limited, further research is needed. Research shows that children < 24 months using 0.2mg/kg/day, once a day, have the same effectiveness as adults. For children > 2 years of age, no optimal dose is recommended, however higher doses are not recommended for adults, an initial dose of 1 mg/kg can be used, then adjusted according to response. Handling missed dose:
Information on how to handle a missed dose is being updated. If you think you have missed a dose, tell your doctor as soon as possible. Treatment of overdose:
Overdosage of clopidogrel can lead to prolonged bleeding and bleeding complications. Animal experiments have shown manifestations of overdose. Symptoms of clopidogrel overdose are vomiting, fatigue, dyspnea, gastrointestinal bleeding. Experimentally, an oral dose of clopidogrel 1500 mg or 2000 mg/kg was lethal to mice and rats: a dose of 3000 mg/kg was lethal to baboons. Treat clopidogrel overdose with platelet transfusions to antagonize the pharmacological effects of clopidogrel.
3. Contraindications of Realdiron Tab
Drug Realdiron Tab. Contraindicated in patients with known allergy to clopidogrel or any of its ingredients. Manifestations of active pathological bleeding (eg, peptic ulcer, intracranial bleeding).
4. Notes when using Realdiron Tab
Use with caution in patients with severe renal impairment, appropriate dosage adjustment is required. In case of bleeding due to trauma, surgery or other diseases, caution should be exercised. In case the patient is about to have surgery, it is necessary to stop taking the drug 5 days before surgery. In the elderly, kidney function should be checked before taking the drug. Ability to drive and use machines: Clopidogrel has no influence on the ability to drive and use machines. Do not use when the drug is found to be expired. If you have any questions during the course of taking the medicine, contact your doctor/pharmacist for timely advice. For pregnant women and lactating women, there are no specific studies on the effects of the drug, so it should be carefully considered and only used under the direction of a doctor.
5. Realdiron Tab . side effects
Very common:
Digestive: Digestive disorders can be up to 27%, may experience abdominal pain, vomiting, loss of appetite, gastritis, constipation. Cardiovascular: Chest pain (8%), angioedema (4%), hypertension (4%). Central nervous system: Headache (3-8%), dizziness (2-6%), fatigue (3%), body aches (6%). Skin: Itching (4%), erythema (3%). Endocrine and metabolic: Hypercholesterolemia (4%). Urinary: Urinary tract infections (3%). Hematology: Bleeding (large 4%, minor 5%), erythema (5%), epistaxis (3%). Liver: Abnormal liver function (<3%). Muscles and bones: Joint pain (6%), back pain (6%). Respiratory: Shortness of breath (5%), rhinitis (4%), bronchitis (4%), upper respiratory infection (9%). Flu-like syndrome (8%). Common:
Cardiovascular: Atrial fibrillation, heart failure, tachycardia, syncope. Nervous: Fever, insomnia, dizziness, anxiety. Skin: Eczema. Endocrine and metabolic: Increased metabolic disorders, goute. Gastrointestinal: Constipation, gastrointestinal bleeding, vomiting Urinary: Cystitis. Hematology: Anemia, bleeding.
6. Drug interactions
Concomitant use of Realdiron with one of the drugs: Aspirin, Heparin, Warfarin increases the risk of bleeding, so caution should be taken when combining these two drugs. Concomitant administration of Realdiron with non-steroidal anti-inflammatory drugs may cause gastrointestinal bleeding, so caution should be exercised. The drug should not be used concurrently with oral anticoagulants. Using stimulants such as alcohol, beer while taking the drug can also affect the effectiveness of the drug and cause unwanted effects.
7. How to store Realdiron Tab
Store the medicine at a temperature below 25 degrees Celsius, in a cool, dry place. Do not expose the product to direct light. Keep out of reach of CHILDREN. The article has provided information about the uses, doses and precautions when using Realdiron Tab. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Realdiron Tab exactly as directed by your doctor.
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