Uses of Pyme Pelium

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1. What is Pyme Pelium?

Pyme Pelium belongs to the group of gastrointestinal drugs, the main ingredient is Domperidone with 10 mg strength and other excipients such as mannitol, corn starch, colloidal silicon dioxide, pregelatinized starch, stearic acid, and magnesium stearate.
Domperidone is a dopamine receptor antagonist with antiemetic effects. The drug has almost no effect on dopamine receptors in the brain, so it has little effect on the nervous system. Domperidone stimulates peristalsis of the gastrointestinal tract, increases the tone of the cardiac sphincter, increases the amplitude of the pyloric sphincter after meals, but does not affect the secretion of gastric juice. Used to improve digestive function in cases of nausea, vomiting, bloating, indigestion.
The drug is rapidly absorbed from the gastrointestinal tract and reaches peak plasma concentrations about 30 minutes after oral administration.

2. Uses of Pyme Pelium

Pyme Pelium is often used in the following cases: Treatment of nausea, vomiting, belching, bloating, indigestion in both adults and children.
Contraindicated to use Pyme Pelium in the following cases:
People who are allergic to any of the ingredients of the drug People with severe and moderate liver dysfunction People with prolactin-secreting pituitary gland. Gastrointestinal bleeding, mechanical intestinal obstruction. People with abnormal heart nerve impulse conduction, then electrolyte disturbances ((rapid hypokalemia, hyperkalemia, hypomagnesaemia), or congestive heart failure. Adults and children under 12 years of age weighing <35kg due to inappropriate dosage.

3. Dosage - how to take Pyme Pelium 10mg

3.1. Dosage Adults and children over 12 years: Take 3 tablets 3 times a day Children under 12 years old: Pyme Pelium tablets should not be suitable for young children and children weighing under 35kg because exact dosage is required. by weight. For patients with hepatic impairment: No dose adjustment is required for patients with mild hepatic impairment. For patients with renal impairment: Use 1-2 times a day and adjust the dose depending on the degree of renal impairment due to the prolonged half-life of the drug in these patients. 3.2. How to use The drug is used orally, should be taken before meals, food can slow down drug absorption. The lowest effective dose should be used, and the maximum duration of dosing should not exceed one week. In case of overdose, symptoms such as altered consciousness, anxiety, convulsions, somnolence, or extrapyramidal symptoms may appear. In that case there is no specific treatment, it is necessary to immediately take symptomatic measures, gastric lavage, closely monitor vital signs, electrocardiogram and use supportive measures. support for patients.

4. Interaction with Pyme Pelium

When used together with anticholinergic drugs can reduce the therapeutic effect of Domperidone. When using Pyme Pelium together with drugs that inhibit gastric acid secretion, it is recommended to take Pyme Pelium before meals and take antacids after meals. Concomitant use with CYP3A4 inhibitors may increase blood levels of Domperidone. When used together with the following classes of drugs may increase the risk of prolonging the QT interval: Antiarrhythmics class IA and III (hydroquinidine, quinidine, amiodarone...), antipsychotic drugs (haloperidol), drugs antidepressants (citalopram, escitalopram), antibiotics (erythromycin, levofloxacin, moxifloxacin, spiramycin), antifungal drugs (pentamidine), antimalarial drugs (halofantrin, lumefantrin), gastroenteritis (cisapride, dolasetron, prucaloprid) ), antihistamines (mequitazine, mizolastin), cancer drugs (toremifen, vandetanib, vincamine) and some other drugs such as bepridil, diphemanil, methadone.

5. Side effects of the drug Pyme Pelium

Headache, stress, anxiety, restlessness, drowsiness. Rash, itching, skin rash Increased prolactin secretion causes lactation, gynecomastia in men, amenorrhea in women. Dry mouth, abdominal pain, diarrhea. Cardiovascular disorders: arrhythmia, QT interval prolongation, torsades de pointes. In the process of using the drug, if the patient shows any serious abnormal symptoms, it is necessary to immediately notify the treating doctor or medical staff for timely advice and treatment.

6. Notes and cautions during taking Pyme Pelium

For patients with renal insufficiency, the dose should be reduced, the dose adjusted according to the degree of renal impairment. Caution should be exercised in those with a history of cardiac nerve impulse conduction disturbances, especially abnormalities in the QT interval, and in patients with impaired renal function. Electrolyte disturbances Pregnancy and lactation There are no adequate data on the use of the drug in pregnancy and Domperidone may be excreted in breast milk, so the benefits and benefits of Domperidone should be carefully weighed. risks of drug use. The drug is unlikely to affect the ability to drive and use machines. The above is some information about the use of Pyme Pelium, if you need advice or have any questions, please contact a qualified doctor / pharmacist for advice.

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