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Pms Opxil 500mg drug with the main ingredient is Cephalexin belonging to the group of drugs to treat parasites, anti-infectives, antivirals, antifungals. Therefore, the drug is used to treat respiratory infections, UTIs, and respiratory infections.
1. What are the uses of Pms Opxil?
Pms Opxil 500mg has the main ingredient is Cephalexin belonging to the group of drugs to treat parasites, anti-infectives, antivirals, antifungals. Accordingly, the doctor will prescribe the drug for patients in the following cases:
Treatment of respiratory infections such as acute and chronic bronchitis, bronchiectasis with superinfection. Treatment of ear, nose and throat infections such as otitis media, mastoiditis, sinusitis, tonsillitis, pharyngitis. Treatment of urinary tract infections: cystitis, prostatitis, reducing the possibility of recurrent urinary tract infections. Treatment of obstetric and gynecological infections. Skin, soft tissue and bone infections. Gonorrhea Prophylactic alternative to penicillin for patients with heart disease who must be treated for oral disease.
2. Dosage and how to use Pms Oxil
2.1. How to use Pms Oxil 500mg is prepared in the form of tablets for oral use. Accordingly, to be able to promote the best effect, patients should take the drug 1 hour before meals.
2.2. Dosage Dosage for adults: 500 mg- 1g/time, every 6 hours. Dosage may be increased to 4g/day, depending on the severity of the infection. For children, use a dose of 25 - 80 mg/kg body weight orally in 1 day, divided into 2-3 oral doses. For severe infections, the maximum dose applied is 100 mg/kg body weight in 24 hours. Treatment of pharyngitis and acute cystitis using a daily dose can be divided into 2 times. Dosage for treatment of otitis media is 75-100mg/day/kg, divided into 4 times. In patients with renal failure, the dose should be adjusted according to creatinine clearance (ml/min) and serum creatinine concentration (micromol/l). Specifically:
Creatinine clearance >= 50 and serum creatinine <= 132 using a drug dose of 1g, used 4 times/day. Creatinine clearance from 49-20 and serum creatinine concentration from 133-295 using a dose of 1g administered 3 times/day. Creatinine clearance from 19-10 and serum creatinine concentration from 296-470 using a dose of 500mg, used 3 times/day. Creatinine clearance <=10 and serum creatinine >=471 using a dosage of 250mg, administered twice a day. Dosage for people to treat gonorrhea:
Men use a dose of 3g Cephalexin and 1g Probenecid. Women use a dose of 2g Cephalexin and 0.5g Probenecid. Note: The duration of drug use depends on the condition of the disease, most of the time taking the drug lasts at least 7 to 10 days. However, patients with complicated, recurrent and chronic urinary tract infections should be treated for 2 weeks (1g/time, twice a day) until the disease is completely cured.
3. Overdose of Pms Oxil and how to handle it
3.1. Manifestations of overdose Most of the time, when a patient uses an excess of the allowed dose, they will show symptoms such as nausea, vomiting, and diarrhea. However, there are some more serious cases that can cause neuromuscular hypersensitivity and seizures, especially in patients with renal failure.
3.2. Treatment Consider the possibility of multiple drug overdose, drug interactions and unusual pharmacokinetics of the patient to provide appropriate treatment. Specifically:
Patients usually do not need gastric lavage, unless the patient has taken cephalexin 5-10 times the normal dose. Hemodialysis can be used to remove drugs from the blood. Protect the patient's respiratory tract, support ventilation and infusion.
4. Side effects when using the drug Pms Opxil
According to clinical studies, the number of patients experiencing unwanted side effects is about 3-6% of the total number of patients treated with Pms Opxil 500. Side effects occur with frequency. Rates are as follows:
Common reactions : Diarrhea, nausea. Uncommon reactions: Increased eosinophils, rash, urticaria, pruritus, increased liver transamirtase. Rare reactions: Headache, dizziness, anaphylactoid reactions, fatigue, neutropenia, thrombocytopenia, gastrointestinal disturbances, abdominal pain, pseudomembranous colitis, erythema multiforme, necrosis epidermal toxicity, Quincke's edema, hepatitis, cholestatic jaundice, genital pruritus, vulvovaginitis, interstitial nephritis.
5. Use Pms Opxil with caution
Pms Opxil should be used with caution in the following cases:
Cephalexin is considered quite safe and well tolerated even in patients allergic to penicillin. However, there is also a very small percentage of patients with cross-allergies, so it is still necessary to carefully monitor health when using the drug. Long-term use of Pms Oxil may result in overgrowth of non-susceptible organisms. Pms Oxil has been reported to cause pseudomembranous colitis with broad-spectrum antibiotics, so it is important to pay attention to the diagnosis of this disease in patients with severe diarrhea during or after taking the drug. Use with caution in patients with renal impairment, the dose should be reduced appropriately. For patients taking cephalexin, there may be a false-positive reaction when testing urine glucose with Benediet's solution, Fehling's solution or Glinitet. Use of Pms Opxil may cause a false-positive Coombs test. Cephalexin may affect the quantification of creatinine by alkaline picrate, possibly giving inaccurate results. However, the increase is not clinically significant. For women in pregnancy: Experimental studies and clinical experience have not shown signs of fetotoxicity and teratogenicity. However, doctors recommend taking the drug only when absolutely necessary. For women who are breast-feeding: The concentration of the drug that can be excreted in breast milk is very low. However, in these cases, consideration should still be given to temporary cessation of breastfeeding while the mother is taking cephalexin. Using Pms Oxil does not affect the ability to drive and use machines.
6. Pms Opxil drug interactions
Some drug interactions of Pms Opxil may occur when the following drugs are used concurrently:
Taking high doses of Pms Opxil 500 with other drugs such as aminoglycosides or potent diuretics (furosemide, ethacrynic acid, piretanide). ) can cause high nephrotoxicity. There have been studies that show that when using Pms Oxil with oral contraceptives, it can reduce the effect of estrogen in oral contraceptives. Cephalexin used with Cholestyramine will slow down the absorption of the drug. Concomitant administration of Probenecid increases serum concentrations and increases the half-life of cephalexin. Pms Opxil 500mg medicine has the main ingredient Cephalexin, which belongs to the group of drugs that treat parasites, infections, viruses, and fungi. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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