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Piracetam is an active ingredient in the group of intellectual drugs, which is widely indicated in many different diseases. This active ingredient in the product is Piracetam Egis 800mg. So what is Piracetam Egis used for?
1. What is Piracetam Egis 800mg?
Piracetam Egis 800mg is made in the form of film-coated tablets with the main active ingredient Piracetam 800mg.In addition, Piracetam Egis 800mg also includes some excipients:
Core pills: Magnesium stearate, povidone K-30; Enclosure: Macrogol 6000, dibutyl sebacate, titanium dioxide C.I. 77891 E.E.C.171, talc, methylcellulose, hypromellose. The main active ingredient of Piracetam Egis 800mg belongs to the group of drugs that are nootropic with a complex mechanism of action. Piracetam increases Nucleotid metabolism in neurons, increases glucose and brain oxygen consumption, and stimulates increased transmission and secretion of Acetylcholine and Dopamine in nerve cells.
Piracetam Egis 800mg has a beneficial effect on the microcirculation and metabolism in the brain of ischemic patients because the drug can increase blood supply to ischemic areas without increasing perfusion. for intact brain regions. Piracetam increases erythrocyte deformability, reduces platelet aggregation, reduces erythrocyte adhesion to blood vessel walls, and reduces capillary constriction. In addition, Piracetam directly stimulates prostacyclin synthesis in intact blood vessel walls.
On the basis of the results of preclinical and clinical pharmacological studies, Piracetam Egis 800mg improved cognitive function (including learning, memory, attention, consciousness) in both healthy and healthy subjects. reduced cognitive functioning. These effects of Piracetam are not accompanied by sedative or stimulant activity.
2. What are the uses of Piracetam Egis?
Piracetam Egis 800mg is indicated in the following cases:
Treatment of symptoms of psychosomatic syndromes (cognitive deficits, memory disorders, inattention, decreased vigilance due to focal brain damage) or diffuse or dysfunctional); Treatment of sequelae (primarily aphasia) due to cerebral infarction; Piracetam Egis 800mg treatment of cortical myoclonus, can be monotherapy or in combination with other drugs; Treatment of dizziness and associated balance disorder (except in cases with vasomotor disturbances and mental instability); Supportive treatment for the loss and cognitive impairment associated with alcoholism and with alcohol withdrawal symptoms; Improve ability in children with learning and reading difficulties, should be combined with other measures; Do not use Piracetam Egis 800mg in the following cases (Contraindications):
Hypersensitivity to Piracetam, other pyrrolidone derivatives or any other ingredient contained in the drug; Severe renal impairment (creatinine clearance less than 20 ml/min); Hemorrhagic stroke; As a general rule, the drug is contraindicated during pregnancy and lactation.
3. Dosage of Piracetam Egis 800mg
3.1. How to use Piracetam Egis 800mg Dosage Piracetam Egis 800mg determined for each specific case according to disease severity and clinical response; Patients need to take Piracetam Egis 800mg film-coated tablets before meals with 100-200 ml of water; The duration of treatment depends on the clinical condition of the patient; In chronic diseases: 6-12 weeks for maximum effect. After three months of treatment the use of Piracetam Egis 800mg must be reviewed and decided whether to continue or not; If longer treatment is required, the dose should be reduced or Piracetam Egis 800mg should be discontinued completely over a period of 6 months. 3.2. Recommended dose of Piracetam Egis 800mg a day depending on specific indications Symptomatic treatment of psychosomatic syndromes: 2.4-4.8g/day (equivalent to 3-6 Piracetam Egis 800mg tablets) divided into 2-3 times; Treatment of sequelae of cerebrovascular accident: The recommended dose is 4.8-6g/day (equivalent to 6-8 Piracetam Egis 800mg tablets); Cortical myoclonus: The recommended starting dose is 7.2g, which can be increased by 4.8g every 3-4 days to a maximum of 20g/day. Then, depending on the clinical improvement, gradually reduce the dose every 1.2g after about 2 days to avoid sudden relapse or withdrawal convulsions; Dizziness: 2.4-4.8g/day divided into 2-3 times; Alcohol withdrawal: The starting dose is 12g (15 Piracetam Egis 800mg tablets), then maintain 2.4g daily (3 Piracetam Egis 800mg tablets); Children with difficulty reading: From 8-13 years old, the maximum daily dose is 3.2g (4 Piracetam Egis 800mg tablets) divided into 2 doses and should be combined with the method of teaching language disabilities. Dosage of Piracetam Egis 800mg for patients with impaired kidney function:
Cl-Cr: 40-60ml/min (creatinine concentration: 1.25-1.7mg%): Reduce Piracetam Egis 800mg to 1⁄3 compared to the normal dose Cl-Cr: 20-40ml/min (creatinine concentration: 1.7-3.0mg%): Reduce Piracetam Egis 800mg to 1⁄4 compared to the normal dose
4. Some cautions and notes when using Piracetam Egis 800mg
When there is renal failure, a lower dose of Piracetam Egis 800mg should be used, and renal function should be monitored regularly, especially elderly patients must be checked for renal function before starting Piracetam Egis.
Piracetam Egis 800mg can lower the seizure threshold in patients with epilepsy and convulsive disorders. Changing anticonvulsant therapy in patients with epilepsy should be carefully considered by a specialist, although Piracetam Egis 800mg may improve the patient's condition.
Due to its inhibitory effect on platelet aggregation, special care should be taken when administering Piracetam Egis 800mg to patients with coagulation problems, major bleeding or after major surgery.
In patients being treated for cortical myoclonus, abrupt discontinuation of Piracetam Egis 800mg may cause acute recurrent seizures and withdrawal seizures.
Particular caution should be exercised when using Piracetam Egis 800mg in patients with hyperthyroidism because of the increased risk of central effects (eg, tremor, hyperactivity, sleep disturbance, confusion).
There are no clinical data showing that Piracetam Egis 800mg affects the ability to drive and use machines, however, the drug still has the potential to cause side effects, so an effect in this group of people cannot be excluded. this.
Use of Piracetam Egis 800mg during pregnancy and lactation: Data from preclinical reproductive toxicity studies do not show any harm to the fetus. Clinical studies performed in pregnant women of the drug were not performed. However, the active substance can cross the placenta and be excreted in human milk, therefore Piracetam Egis 800mg should not be used in general in pregnant and lactating patients, except in special cases where the therapeutic benefit is great. than the risk of harm.
5. Undesirable effects of Piracetam Egis 800mg
The following undesirable effects have been reported with Piracetam Egis 800mg:
Severe allergic reactions or symptoms due to hypersensitivity; Restlessness, anxiety, hallucinations or confusion; Disorders of balance and coordination; More severe epilepsy; Dizzy; Abdominal pain, epigastric pain, diarrhea, nausea, vomiting; Edema, dermatitis, itching, urticaria
6. Piracetam Egis 800mg drug interactions
Piracetam Egis 800mg when used in combination with drugs that stimulate the central nervous system can increase the stimulant effect; Piracetam Egis 800mg concomitant use with sedative drugs may lead to increased dyskinesia; Piracetam Egis 800mg combined with thyroid hormone preparations (T3+T4) can increase central effects such as tremor, hyperactivity, sleep disturbance, confusion; According to the results of a study in patients with severe and recurrent thromboembolism, a daily dose of 12 Piracetam Egis 800mg (9.6g) tablets had no effect on the dose of Acenocoumarol used to maintain INR 2.5-3.5, but the drug again significantly reduced platelet aggregation, beta-thromboglobulin release, fibrinogen levels, von Willebrand factor, and reduced the viscosity of whole blood and plasma; Patients receiving antiepileptic drugs (eg, Carbamazepine, Phenytoin, Phenobarbital or Sodium valproate) 25 tablets of Piracetam Egis 800 mg (20 g) daily for 4 weeks did not change the trough plasma concentrations. plasma of antiepileptic drugs; Co-administration of 2 Piracetam Egis 800mg (1.6g) tablets with alcohol did not show any change in plasma concentrations of either substance.
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