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Pegaset 150 is a psychotropic drug, with the main ingredient being Pregabalin 150mg. Pegaset 150 is used in the treatment of neuropathic pain in diabetic patients with peripheral neuropathy or postherpetic neuralgia, or neuropathic pain associated with spinal cord injury.1. Uses of Pegaset 150
Pegaset belongs to the group of psychotropic drugs, the main ingredient is Pregabalin 150mg. Pregabalin reduces the release of calcium-dependent nociceptive neurotransmitters in the spinal cord.Pegaset drug is made in the form of hard capsules and is indicated for use in the following cases:
Treatment of neuropathic pain in diabetic patients with peripheral neuropathy or postherpetic neuralgia, or neuropathic pain nerve is associated with spinal cord injury. Adjuvant treatment of partial-onset epilepsy in adults. Treatment of fibromyalgia.
2. How to use and dose Pegaset
Pegaset is taken orally, taken with water and can be taken on an empty or full stomach. While taking the drug, the patient should pay special attention to following the doctor's instructions and not suddenly stopping the drug.Dosage of Pegaset in the treatment of neuropathic pain in diabetic patients with peripheral neuropathy:
Initial dose: 50mg/time, 3 times/day (equivalent to 150mg/day). Depending on the tolerability of the patient and the effectiveness of the drug, the dose can be increased to 300 mg/day for 1 week. Maximum dose: 100mg/time, 3 times/day (equivalent to 300mg/day). This dose of Pegaset may be indicated in patients with a creatinine clearance of at least 60 mL/min. Doses above 300 mg/day are not recommended. Patients with renal impairment: Adjust dose because the drug is mainly eliminated by the kidneys. Dosage of Pegaset in the treatment of post-herpetic neuralgia:
Usual dose: 75 - 150mg/time, 2 times/day or 50-100mg/time, 3 times/day (equivalent to 150-300mg/day). This dose may be indicated in patients with a creatinine clearance of at least 60 mL/min. Initial dose: 75mg/time, 2 times/day or 50mg/time, 3 times/day (equivalent to 150mg/day). Depending on the patient's tolerability of Pegaset and the effectiveness of the drug, the dose can be increased to 300mg/day within 1 week. However, if after 2-4 weeks of treatment the pain is not relieved with 300mg/day and the patient can tolerate higher doses, the dose can be increased to 300mg/times and twice/day or 200mg. / time and 3 times / day (ie 600mg / day). Patients with renal impairment: Adjust the dose of Pegaset 150 because the drug is mainly eliminated by the kidneys. Doses above 300 mg/day are not recommended. Dosage of Pegaset in adjuvant treatment of partial-onset epilepsy in adults:
Recommended dose: In the range of 150-600mg/day, divided into 2-3 times a day. The total initial dose should not exceed 150 mg/day (i.e. 75 mg twice daily, or 50 mg three times daily). Maximum dose: Depending on the patient's tolerability of Pegaset and the effectiveness of the drug, the dose can be increased to 600mg/day. Patients with renal impairment: Adjust dose because the drug is mainly eliminated by the kidneys. Dosage of Pegaset in the treatment of fibromyalgia:
Recommended dose: 300 - 450mg/day. Initial dose: 75mg / time, 2 times / day (equivalent to 150mg / day). Depending on the tolerability of the patient and the effectiveness of the drug, the dose can be increased to 150mg/time and used twice a day (equivalent to 300mg/day) for 1 week. However, if pain is not relieved with Pegaset 300mg/day, the dose can be increased to 225mg/times and twice/day (equivalent to 450mg/day). Doses above 45mg/day are not recommended. Patients with renal impairment: Adjust dose because the drug is mainly eliminated by the kidneys. Dosage of Pegaset in the treatment of neuropathic pain caused by spinal cord injury:
Recommended dose: In the range of 150 - 600mg/day. The total initial dose should not exceed 150 mg/day (ie 75 mg/time and twice/day). Depending on the tolerability of the patient and the effectiveness of the drug, the dose can be increased to 150mg / time and used 2 times / day (equivalent to 300mg / day) for 1 week. However, if after 2-3 weeks of treatment the pain is not relieved with Pegaset 300mg/day and the patient can tolerate the higher dose, the dose can be increased to 300mg/time (ie 600mg/day) ). Patients with renal impairment: Adjust dose because the drug is mainly eliminated by the kidneys. Overdose of Pegaset can cause coma, not breathing, then, the patient should be treated immediately.
3. Side effects of the drug Pegaset
Pegaset medicine may cause some of the following undesirable side effects:Digestion: Dry mouth, nausea, vomiting, flatulence, constipation, appetite, weight gain. Neurological: Headache, dizziness, fatigue, mood swings, anxiety, difficulty concentrating, trouble remembering, confusion or forgetfulness, language problems. Musculoskeletal: Back pain, loss of balance, lack of coordination, an uncontrolled body part, muscle weakness, seizures. Extremities: Swelling of hands, feet, hands, ankles or legs. Pegaset medicine can cause some serious side effects such as:
Vision: Double vision, blurred vision, vision changes. Anaphylactic reactions: Urticaria, itching, rash, blistering of the skin, swelling of the face, mouth, tongue, throat, difficulty breathing or wheezing, chest pain, muscle pain with fever. For people with diabetes, Pegaset can cause skin sores, rashes, or other skin problems.
If you see any strange symptoms after taking the drug, the patient should immediately notify the doctor.
4. Some notes when using Pegaset
Do not use Pegaset in people with hypersensitivity to any of its ingredients and in children under 18 years of age (because the effectiveness and safety of the drug has not been established). People with kidney failure, cardiovascular disease, diabetes need to be careful when using Pegaset 150 because the drug can promote encephalopathy, especially in the elderly. If the patient wants to stop taking Pegaset, the drug should be stopped gradually over at least 1 week. If angioedema is present, the patient should stop taking Pegaset immediately. While taking Pegaset, patients should be closely monitored to control suicidal ideation or behavior, and to avoid drug abuse. Women who are pregnant or breast-feeding should not take Pegaset unless absolutely necessary. If taking the drug, breast-feeding must be stopped. Pegaset may interact with pain relievers (containing anesthetics), tranquilizers, sleeping pills, allergy medications, cold medicines, antidepressants, muscle relaxers and increase the side effect of Pregabalin which is drowsiness. or dizzy. To limit the risk of side effects due to drug interactions, before taking Pegaset 150, patients need to inform their doctor about the drugs they have been using, including: blood pressure drugs, heart drugs,... The use of Pegaset is to reduce the release of nociceptive neurotransmitters in neuropathic pain in diabetic patients with peripheral neuropathy or spinal cord injury, postherpetic neuralgia. It is also used to treat fibromyalgia and partial-onset epilepsy in adults.Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
