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Parokey 30 is a drug on the list of anxiolytics, with the main ingredient being paroxetine hydrochloride hemihydrate. Parokey 30 drug is effective in the treatment of depression, panic disorder, anxiety disorder.... Parokey 30 is often indicated for treatment in specific cases such as: Depression, social phobia. , panic disorder, ....
1. What is Parokey 30?
In addition to the main ingredient, Paroxetin, in each Parokey 30 tablet, there are excipients such as: Cellactose 80, copovidone, sodium starch glycolate, magnesium stearate, HPMC E6, titanium dioxide, polysorbate, PEG 400, talc, castor oil.. .. helps ensure the volume, solubility, and stability of a single Parokey 30 tablet.
Parokey 30 is made in the form of film-coated tablets, packing specification: box of 6 blisters x 10 tablets.
2. Uses of the drug Parokey 30
With the main ingredient is Paroxetin - this is a derivative of phenylpiperidin, is an antidepressant of the group that selectively inhibits serotonin reuptake at the anterior synapse of serotoninergic neurons. Low levels of Serotonin in the body are responsible for depression and other related anxiety disorders.Paroxetin increases Serotonin concentration to the synapse, bringing Serotonin levels to normal, thereby improving depressive symptoms in patients with depression problems, anxiety disorders, panic disorders. With the above mechanism of action, Parokey 30 is often indicated for treatment in the following specific cases:
Treatment of patients with depression; Panic disorder; Anxiety disorders; Social phobia (also called social anxiety disorder); Obsessive-compulsive disorder, obsessive-compulsive disorder; Traumatic stress disorder, post-traumatic stress disorder.
3. Contraindications of the drug Parokey 30
Parokey 30 should not be used in the following cases:
Patients with a history of allergy or hypersensitivity to any of the ingredients of Parokey 30. The patient is being treated with monoamine oxidase inhibitors. (MAO). The patient is being treated with pimozide, thioridazine.
4. Dosage and how to use Parokey 30
Parokey 30 is used as prescribed by the doctor. You can refer to the dose as follows:
Dosage of Parokey 30 for adults:
To treat patients with depression: The starting dose is 20mg/day. After each week, it can be increased by 10mg, the maximum dose should not exceed 50mg/day. For the treatment of obsessive-compulsive disorder: an initial dose of 20 mg/day. After at least 1 week, the dose can be increased by 10 mg, the maintenance dose is 40 mg/day, the maximum dose should not exceed 60 mg/day. For the treatment of panic disorder: Initial dose of 10 mg/day, after at least 1 week may be increased in increments of 10 mg/day. The maximum dose should not exceed 40mg/day. For the treatment of social anxiety disorder also known as social phobia: Initial dose of 20mg/day. After each week, it can be increased by 10mg/day, the maximum dose should not exceed 50mg/day. For the treatment of post-traumatic stress disorder: The recommended dose is 20 mg/day. After each week, it can be increased by 10mg/day, the maximum dose should not exceed 50mg/day. Dosage of Parokey 30 in the elderly:
Use the same starting dose as an adult, the maximum dose should not exceed 40mg/day. Children and adolescents under 18 years of age:
The use of Parokey 30 is not recommended. Dosage of Parokey 30 in patients with liver and kidney failure:
Because paroxetine is metabolised very strongly in the liver, it can cause liver damage, so the dose Use Parokey 30 in patients with hepatic impairment lowest initially, the maximum dose should not exceed 20mg/day. In patients with renal impairment, the mean plasma concentrations of paroxetine were approximately 4 times higher than in healthy subjects. Therefore, the initial dose of Parokey 30 in patients with renal failure should be lowest, the maximum dose should not exceed 20mg/day. How to use Parokey 30:
Parokey 30 is taken orally, the best time is in the morning and taken with food. The tablet can be broken in half if necessary, do not chew the tablet.
If you forget to take a dose of Parokey 30, take it as soon as you remember. However, if it is almost time for your next dose of Parokey 30, skip the missed dose and take your next dose exactly as directed by your doctor. Never take a double dose of Parokey 30 to make up for the missed dose.
Symptoms of an overdose of Parokey 30: Nausea, vomiting, mild excitement, sweating, dizziness, agitation. If you accidentally overdose and have symptoms of an overdose of Parokey 30, please immediately go to the nearest medical facility for timely treatment.
5. Side effects of the drug Parokey 30
Parokey 30 may cause unwanted effects. However, this is not the case with all patients taking the drug. Common side effects of Parokey 30 include:
Decreased concentration, nausea, sexual dysfunction. Dizziness, tremor, headache, blurred vision, drowsiness, agitation, insomnia. Constipation, diarrhea, dry mouth, decreased appetite. Sweating, weakness, weight gain. Increased cholesterol levels, sweating, weakness, weight gain. Abnormal bleeding, altered glycemic control in patients with diabetes. Skin rashes, allergies, eye infections, mouth ulcers, aches and pains, extrapyramidal disorders, hyponatremia, convulsions, panic attacks, restlessness. Bradycardia, thrombocytopenia, severe allergic reactions, toxic epidermal necrolysis, serotonin syndrome such as confusion, inability to rest, sweating. Acute glaucoma (also known as natural headache) such as: Eye pain, blurred vision
6. Drug interactions
When using Parokey 30 with other serotonergic drugs such as L-tryptophan, Triptan, tramadol, linezolid... may increase the frequency of 5-HT side effects (serotonin syndrome such as: confusion, can rest, sweat). When using Parokey 30 together with monoamine oxidase (MAO) inhibitors such as moclobemide, selegiline, confusion, agitation, increased adverse drug reactions in the gastrointestinal tract, high fever, severe convulsions, increased blood pressure pressure. When using Parokey 30 together with Lithium, it changes the concentration of Lithium in the blood. The drug Parokey 30 strongly inhibits the liver enzymes CYP2D6 When using Parokey 30 together with pimozide: 2.5 times increase in pimozide concentration leading to increased cardiotoxicity, prolongation of the QT interval. When using Parokey 30 together with thioridazine: Increases the toxicity of thioridazine on the heart, causing prolongation of the QT interval, torsades de pointes, cardiac arrest. When using Parokey 30 at the same time with tricyclic antidepressants such as: Maprotilin, trazodone: Increases the concentration of antidepressants. When used together with Fosamprenavir, ritonavir: Reduces plasma concentrations of parokey 30. When using parokey 30 together with procyclidin: Increases the concentration of procyclidin. Paroxetin is very strongly metabolized in the liver and can cause liver damage, so do not use Parokey 30 with alcoholic beverages because of increased toxicity on the liver. When using Parokey 30 with drugs such as: Warfarin, coumadin will thin the blood. When using Parokey 30 with NSAIDs and acetyl salicylic acid increases the risk of bleeding. When using Parokey 30 together with pravastatin: Increases blood glucose levels. When using Parokey 30 with drugs that are highly bound to plasma proteins: Increases the concentration of free drugs in the blood plasma and increases unwanted effects.
7. Caution
Parokey 30 may cause unwanted effects such as headache, dizziness, drowsiness, confusion, visual changes. Therefore, after taking the drug, it is necessary to avoid jobs such as driving, operating machinery and things that require alertness. Before taking Parokey 30, tell your doctor if you have any health problems such as: eye disease, heart failure, liver, kidney, epilepsy, diabetes, high blood pressure, money. History of seizures or bleeding disorders, receiving electroconvulsive therapy. Parokey 30 has a risk of causing birth defects in the fetus when the mother uses it in the first 3 months of pregnancy. Using Parokey 30 in the last 3 months of pregnancy increases the risk of persistent pulmonary hypertension in the newborn, not enough oxygen in the baby's blood. Therefore, only use Parokey 30 when absolutely necessary, the benefits outweigh the risks. Tell your doctor about any new problems or worsening symptoms such as: Mood, behavior changes, anxiety, panic attacks, trouble sleeping, irritability, thoughts of suicide or hurting yourself me.
8. Store Parokey 30
Store Parokey 30 at room temperature, in a cool, dry place, away from light and reach of children.
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